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Biomedical subjects

M F Chen

Publications and source records attributed to M F Chen.

At least 343 records · Page 19Linked to original sources
PubMed1984

The cumulative scanning electron microscopic changes in baby mouse lungs following prenatal and postnatal exposures to nicotine.

Half of the offspring from nicotine exposed and control mother mice were cross-fostered at birth to form four groups of those exposed to nicotine only during the gestational period (NC), only during the lactational period (CN), throughout both periods (NN), or exposed to none (CC). Nodular mucosal bulges (neuroepithelial bodies, NEB) were found in all groups; their number decreased with the increase in the age in the control group (CC). The bulges were large and irregular in all nicotine exposed groups, especially in the NN group. Although they also decreased in number with age, NEB were significantly retained and abnormal in the NN group compared with the NC and CC groups on day 30 (p less than 0.01). In addition, the bronchioles were tortuous in the nicotine exposed groups probably due to the expansion of mucosal depressions, pits, and fenestrations. In mice, maternal exposures to a small dosage of nicotine throughout both gestational and lactating periods appear to induce more baby lung changes than when the exposure to nicotine is limited to either period alone. More importantly, nicotine induced baby lung changes observed on day 5 appear to regress by day 30, if the exposure to nicotine is discontinued at birth.

Animals↗
PubMed1983

Hematobilia from ruptured hepatic artery aneurysm. Report of two cases.

Hematobilia secondary to hepatic artery aneurysm must be considered in the differential diagnosis of unexplained gastrointestinal tract hemorrhage. We treated two patients with ruptured hepatic artery aneurysm. One had hepatic artery aneurysm proximal to the gastroduodenal artery; the other had an intrahepatic pseudoaneurysm in the right lobe of the liver. The first patient was treated with obliterative endoaneurysmorrhaphy. The second required ligation of feeding vessels, cholecystectomy, and reconstruction of cholecystoduodenal fistula.

Aneurysm↗
PubMed1983

Use of fiberoptic choledochoscope in common bile duct and intrahepatic duct exploration.

This report summarizes our experience with 339 consecutive flexible fiberoptic choledochoscopic examinations performed in the course of 598 common bile duct explorations for biliary tract stones. Routine choledochoscopy added 5 to 10 minutes to the operation and caused no complications. In 81 of the patients, additional stones were discovered with choledochofiberscopy after completion of routine bile duct exploration. Postoperative cholangiography demonstrated a retained stone in 57 patients (two in the common bile duct and 55 in the intrahepatic ducts). Forty-two patients with stones retained in the intrahepatic ducts were diagnosed during operation with the fiberoptic choledochoscope, but those stones were very difficult for us to remove. The accuracy of postexploratory choledochoscopy in diagnosis of stones in the common bile duct and intrahepatic ducts was 99.0% and 90.5%, respectively. Choledochofiberscopy is useful in exploration of the common bile duct and a safe procedure in the diagnosis of biliary tract stones during operation.

Bile Ducts, Intrahepatic↗
PubMed1983

The folacin contents of foods as measured by a radiometric microbiologic method.

A radiometric microbiologic assay for folate was applied to measure food folacin levels. Sixteen different foods were analyzed. The total folacin content of the 16 foods obtained by the radiometric microbiologic method was found to compare well with that obtained by the turbidimetric microbiologic method. The folacin content ranged from 9 ng/ml of frozen reconstituted grape juice to 1820 micrograms/100 g of the cereal Total. The study showed that the radiometric microbiologic assay can be used to measure folacin content in foods.

Biological Assay↗