PubMed Health⌕ Search

Biomedical subjects

M Fiore

Publications and source records attributed to M Fiore.

At least 91 records · Page 5Linked to original sources
PubMed1987

Occupation and risk of death from coronary heart disease.

Conflicting data have been reported regarding the association between occupation and coronary heart disease. We evaluated data on a series of 568 married men who died of coronary heart disease and an equal number of controls matched for age, sex, and neighborhood of residence. Information was collected from the wives of both cases and controls on a larger number of variables, including usual occupation, job-related and leisure-time physical activity, medical history, and life-style. Usual occupation was dichotomized into blue-collar and white-collar work according to the Edwards' classification. White-collar workers had a statistically significant 30% decreased risk of fatal coronary heart disease compared with blue-collar workers once the effects of reported coronary risk factors were considered (relative risk, 0.70; 95% confidence limits, 0.5 to 0.96). These data suggest that occupation is significantly associated with fatal coronary heart disease, and that this increased risk is not explained by a large number of known coronary risk factors. It still remains unclear, however, whether other uncontrolled variables explain the observed association.

Adult↗
PubMed1987

Non-Hodgkin's lymphoma in childhood presenting as thyroid enlargement.

The authors report a case of a 10-year-old girl with early involvement of the thyroid gland by non-Hodgkin's lymphoma, an uncommon site of presentation of childhood lymphomas. In pediatrics, thyroid enlargement is more often caused by lymphocytic thyroiditis. The good response to therapy, in spite of the advanced stage of the disease, is noted.

Child↗
PubMed1986

An in vitro and in vivo study on mutagenic activity of fluoranthene: comparison between cytogenetic studies and HPLC analysis.

The polycyclic aromatic hydrocarbon, fluoranthene (FT), has been shown to induce SCEs in vitro in CHO cells in the presence of metabolic activation. Negative results were obtained in vivo in mice. The HPLC analysis performed to investigate the presence of metabolites of FT both in the serum of treated mice and in culture medium of CHO cells confirmed some differences between in vitro and in vivo metabolism.

Animals↗
PubMed1986

Expression of the autosomal folate-sensitive fragile sites in ten kindreds with Martin-Bell syndrome.

The authors analyse the expression of all the folate-sensitive fra sites in a sample of 24 male patients with Martin-Bell syndrome (MBS) and their 12 mothers distributed in 10 kindreds. The cytogenetic results are compared with that of a control group, constituted by 8 unrelated normal subjects. Except for the fra Xq27, there was no autosomal folate-sensitive fra site significantly more expressed in patients with MBS than in the control group. On the basis of the present cytogenetic sample of about 6 500 R-banded mitoses, a list of all the in vitro folate-sensitive fra sites and their relative frequencies is given.

Chromosome Fragile Sites↗
PubMed1986

Double independent balanced translocation in a girl with mild phenotypical stigmata.

A case of de novo double independent balanced translocation t(1;7)(q44;q22), t(8;10)(q22;q26) in a girl with mild phenotypical stigmata is reported. Beside hyposomia with retarded bone age and slightly dysmorphic ear, no other abnormality was detectable and the psychomotor development was normal. A review of the similar casuistry in literature is made.

Child, Preschool↗
PubMed1984

Enhancement of induced sister chromatid exchange and chromosomal aberrations by inhibitors of DNA repair processes.

The effect of post-treatment with inhibitors of DNA synthesis (hydroxyurea, aphidicolin) and repair (caffeine, 3-aminobenzamide) on the frequencies of chromosomal aberrations and sister chromatid exchange (SCE) induced by mitomycin C and decarbamoyl mitomycin C both in Chinese hamster cells and in human lymphocytes in vitro has been studied. The data show that in the case of Chinese hamster and human lymphocytes mitomycin C-treated cells there is an increased frequency of both chromosomal aberrations and SCE after a G2 post-treatment with the inhibitors, while no increase is observed for decarbamoyl mitomycin C-treated cells. Since SCE are DNA synthesis-dependent phenomenon, an increase in the frequency of SCE also in the G2 phase might suggest that after mitomycin C treatment there is a residual DNA synthesis still going on very late in the cell cycle.

Animals↗
PubMed1983

Formation of chromatid-type aberrations in G2 stage of the cell cycle.

CHO cells were treated in G1 stage of the cell cycle with chromosome-breaking agents that act in an S-dependent manner. The cells were challenged in G2 stage, before fixation, with various inhibitors of DNA synthesis or repair. Short-wave UV, mitomycin C, decarbomyl mitomycin and 4-nitroquinoline oxide (4NQO) were used as chromosome-breaking agents. The inhibitors of DNA repair or synthesis used were hydroxyurea, aphidicolin and caffeine. Permeabilization of cells followed by a treatment with Neurospora endonuclease (a treatment to convert DNA single-strand breaks into double-strand breaks) did not have any influence on the frequencies of chromatid aberrations induced by the chemicals used, whereas with the inhibitors the extent of potentiation varied depending on the mutagen and the inhibitor used.

Animals↗
PubMed1982

Immune response of dogs and rabbits to intrabronchial trimellitic anhydride.

8 dogs and 7 rabbits were immunized intrabronchially with trimellitic anhydride (TMA) using three different immunizing doses. An immune response occurred in both animal species. Predominantly IgG with lower levels of IgM and IgA antibodies against trimellityl-erythrocytes (TM-E) were detected on both dogs and rabbits. Antibody binding of TM125I dog serum albumin (TM125I-DSA) occurred in most dogs and of TM125I rabbit serum albumin (TM125I-RSA) in 1 out of 7 rabbits. Lymphocyte reactivity was present in all 8 dogs. Death occurred in the 2 dogs immunized with the low dose (0.1 mg/kg) of TMA, in 2 of the 4 dogs immunized with the moderate dose (1.0 mg/kg), and in neither of the 2 dogs immunized repeatedly with the high dose (10.0 mg/kg). No correlation of deaths could be made with serum levels of anti-TM-E antibody or anti-TM125I-DSA antibody binding, or lymphocyte reactivity. The deaths occurred early in the TMA immunizations. All antibody levels in the diseased animals were less than those seen in human workers with TMA-related respiratory disease. Autopsy findings in the 4 dogs showed hemorrhagic pneumonitis possibly analogous to the pulmonary lesions seen in the hemorrhagic pneumonitis of some workers exposed to TMA fumes. TMA as used in these experiments was not toxic to dogs as the high doses of TMA (10.0 mg/kg) did not lead to death which did occur at the lower doses. No deaths occurred in the 7 rabbits immunized with 1.0 mg TMA/kg. The immune responses and pathological findings in dogs encourage further work in the development of animal models of TMA immunologic lung disease.

Animals↗
PubMed1980

The HLA system in the Campania region: a genetic study.

The HLA-A, -B and -C locus gene frequencies and the significant A, B and B, C haplotypes of the population of Campania (Southern Italy) are reported. From a comparison of gene frequencies and from an overall genetic distance evaluation with other European and Mediterranean populations the typical Mediterranean structure of the Campanian population is confirmed. While keeping several Middle Eastern features, it places itself as far from Northern Italy (Bergamo) as from the Spanish and the French populations. Among all the groups compared, including Turkish and Lebanese, the largest distance is measured from the English, the Danish and the German populations.

Chromosome Mapping↗
PubMedDate not supplied

The pattern of HLA antigens in two Italian regions.

The HLA antigen and gene frequencies (A, B and C loci) in the populations of the Bergamo area and of the Campania region are compared. Significant discrepancies were found between the two sets of data, as regards the distribution of single genes and the haplotype frequencies and deltas as well. Stone of the frequencies diverge significantly also from accepted data on European Caucasoid populations.

Biometry↗
PubMedDate not supplied

Medium and long-term behavioral effects in mice of extended gestational exposure to ozone.

CD-1 mice were continuously exposed to ozone (O3) from 6 days before the formation of breeding pairs to Day 17 of pregnancy. The concentrations used were 0, 0.2, 0.4, and 0.6 ppm; the lowest-observed-effect levels for eye irritation and respiratory function are in the range of 0.08-0.2 ppm for both humans and animals (47). Ozone failed to produce significant effects on either reproductive performance, postnatal somatic and neurobehavioral development (as assessed by a Fox test battery) or adult motor activity (including within-session habituation). In social interaction tests performed in the pre-juvenile period (23-25 days) and the juvenile period (43-45 days), social response endpoints were not modified in O3 mice, but exploration and self-grooming showed concentration dependent effects (decrease and increase, respectively). Performance at 84-98 days in an eight-arm radial maze with water reinforcement was initially impaired in O3 mice, but the results were not entirely consistent; e.g., the data failed to show a concentration dependence of the effects. Overall, the data confirm previous results of an experiment with more limited exposure [pregnancy Days 7-17 (6)] by showing that prenatal O3 exposure, even when extended to include a period before the start of pregnancy and the preimplantation phase, does not produce major or widespread somatic and neurobehavioral effects. Some of the results, however, point to subtle or borderline behavioral deficits which deserve to be considered both in further animal experiments and in the assessment of risk to developing humans.(ABSTRACT TRUNCATED AT 250 WORDS)

Analysis of Variance↗
PubMedDate not supplied

Prenatal exposure to methylazoxymethanol acetate in the rat alters neurotrophin levels and behavior: considerations for neurodevelopmental diseases.

We did a single injection of methylazoxymethanol acetate (MAM) in pregnant rats on gestational day (GD) 11 or 12 to investigate the long-lasting effects of early entorhinal cortex (EC) and hippocampus maldevelopment on behavior, brain nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels, and the neurotrophin receptor p75 and choline acetyltransferase (ChAT) immunoreactivity. Adult animals treated with MAM had compromised EC development and showed changes in locomotion and displacement activities. In addition, rats treated on GD 12 had increased concentration of NGF and BDNF in the EC and hippocampus if compared to control rats. Prenatal MAM administration did not affect significantly p75 and ChAT distribution in the EC and septum. Results are discussed in reference to the neurodevelopmental hypothesis of psychiatric disorders.

Adaptor Proteins, Signal Transducing↗