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Biomedical subjects

M Fishman

Publications and source records attributed to M Fishman.

At least 73 records · Page 4Linked to original sources
PubMed1981

Characterization of the recognition of target cells sensitive or resistant to cytolysis by activated rat peritoneal macrophages.

The interaction between tumoricidal rat peritoneal exudate macrophages and normal or neoplastic target cells has been examined both with respect to the sensitivity of the target cells to macrophage-mediated cytolysis and the ability of such targets to compete with one another for the lytic activity of macrophages. The results demonstrate that, in confirmation of earlier work from other laboratories, target cells are either sensitive or largely resistant to lysis, and such sensitivity correlates well with the neoplastic phenotype of the target cell. However, in target cell competition experiments all cultured cells as well as Con A-stimulated splenocytes and freshly isolated thymocytes exhibit the capacity to block cytolysis of sensitive indicator targets. In contrast, freshly prepared non-mitogen-stimulated splenic or lymph node lymphocytes are completely devoid of competitive activity. These results show that macrophages can recognize and interact with both normal and tumorigenic cells and that such target recognition can be distinguished from target cytolysis. Furthermore, the evidence suggests that at least 1 target cell feature that correlates with recognition is cell cycle traverse.

Animals↗
PubMed1979

Visual loss and foveal lesions in Usher's syndrome.

Forty-eight patients with Usher's syndrome were assess for the degree of visual loss, extent of lens opacities, and presence of foveal lesions. Twenty-one patients (44%) showed either atrophic or cystic-appearing bilateral foveal changes. Despite having foveal lesions and variable degrees of lens opacities most patients maintained central visual acuity of 20/60 or better until their middle 30s.

Adolescent↗
PubMed1978

Multiple ocular anomalies associated with maternal LSD ingestion.

Severe ocular malformations, including microphthalmos, intraocular cartilage, cataract, persistent hyperplastic primary vitreous, and retinal dysplasia, occurred in a premature baby girl. The mother had ingested LSD during the first trimester of pregnancy. To our knowledge, this is the third case reported of ocular teratogenesis associated with maternal LSD ingestion. Further cases must be documented to establish an actual cause and effect relationship between the drug and the induced malformations.

Abnormalities, Drug-Induced↗
PubMed1978

Vitelliform lesions associated with retinal pigment epithelial detachment.

Two patients with bilateral vitelliform macular lesions had normal electro-oculogram findings. The fluorescein angiograms showed retinal pigment epithelial detachment. Detachment of the retinal pigment epithelium associated with lipid and/or protein accumulation within the subpigment epithelial space represents another mechanism by which a lesion ophthalmoscopically similar to that seen in classical Best's disease can be produced.

Adult↗
PubMed1977

Pseudovitelliform macular degeneration.

Three patients with vitelliform-like macular lesions had normal electroooculogram (EOG) light-peak/dark-trough ratios, unlike typical cases of vitelliform dystrophy (Best macular dystrophy). Leakage of fluorescein dye from perifoveal cappillaries implicated an increased permeability of these vessels as the probable cause for the vitelliform-appearing lesions. All patients with vitelliform lesions demonstrating normal EOG ratios should have an evaluation by fluorescein angiography to rule out a diagnosis of what we prefer to call pseudovitelliform macular degeneration.

Aged↗
PubMed1977

Macular lesions associated with retinitis pigmentosa.

Of 31 patients with retinitis pigmentosa, 18 (58%) had lesions of the retinal pigmentary epithelium within the maculae of both eyes. Six of the 31 patients (19%) showed macular cysts or holes (five bilateral, one unilateral) without angiographic evidence of leakage from perifoveal capillaries, while seven patients (23%) had macular cysts in both eyes associated with cystoid macular edema evident by fluorescein angiography. We believe that the macular cysts or holes were caused by changes at the vitreoretinal interface, eg, vitreous traction and preretinal membranes. Other pathologic sequences may also be responsible, such as an intrinsic increase in the permeability of retinal capillaries.

Adolescent↗
PubMed1977

Foveal lesions seen in retinitis pigmentosa.

A total of 110 patients with retinitis pigmentosa were prospectively and consecutively evaluated for the presence of foveal lesions. Of these 69 (63 percent) patients showed one of two types of separate and distinct bilateral foveal lesions. Forty-seven (43 percent) patients had atrophic-appearing lesions of the retinal pigment epithelium within the fovea of both eyes, and an additional 22 (20 percent) patients showed bitalteral foveal cysts or partial-thickness holes. Of the 22 patients in this last group, 16 showed cystoid macular edema evident on fluorescein angiography.

Aged↗
PubMed1976

The electro-oculogram in diffuse (familial) drusen.

Twelve patients with diffuse drusen of Bruch membrane had their condition evaluated by electro-oculography (EOG). All had normal EOG light-peak/dark-trough ratios, which suggests that the disease does not involve a diffuse functional abnormality of the retinal pigment epithelium. This finding is in contrast to the abnormal EOG ratios reported in patients with fundus flavimaculatus. Categorizing these two diseases along with fundus albipunctatus as flecked retina syndrome should be continued on the basis of the somewhat similar morphologic appearance of the lesions, rather than because of similar results on functional testing.

Adult↗
PubMed1976

Studies on tolerance induction in vitro. II. Requirements for the generation and transfer of suppressor cell activity.

The induction of specific immunologic tolerance and its transfer has been studied in the in vitro response of unprimed rabbit spleen cells to solubilized phage antigens. Evidence presented shows that only viable cells transfer tolerance and that the responsible cells appear devoid of membrane-bound antigen but are sensitive to anti-thymocyte serum. It appears, therefore, that although the in vitro response to solubilized S-T2 has no demonstrable requirement for T "helper" cells, it is subject to the action of T "supp "suppressor" cells.

Animals↗