Biomedical subjects
Publications and source records attributed to M Fu.
Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma in adults, but is distinctly rare as a primary tumor of the heart. Herein we report a case of left ventricular MFH obstructing the outflow tract and presenting as congestive heart failure. Surgical removal of the mass confirmed the tissue diagnosis of MFH. To our knowledge, this is the first report of MFH originating from the left ventricle.
Experiments indicated that the ethanol extract and ether extract from Rhizoma Cynanchi Stauntonii showed obvious antitussive and expectorant effects in mice with stomach administration. The antitussive effect of ethanol extract was stronger than the expectorant effect. The water extract showed a certain expectorant effect but no marked antitussive effect with oral administration. Obvious anti-inflammatory effect was observed on croton oil-caused mouse ear swell with intraperitoneal injection.
A detailed diet history was taken from 326 Chinese adults, 116 college students in Chengdu, China, and 300 Japanese adults and 4529 college students in Fukuoka, Japan. Both populations consume high carbohydrate and low fat diet, but the Chinese diet was higher in carbohydrate, cereal energy/total energy ratio and polyunsaturated fatty acids/saturated fatty acids ratio, and lower in protein, fat and animal fat/total fat ratio compared to the Japanese diet. Cholesterol intake was significantly lower in Chinese than in Japanese (P < 0.001). Physical activity index in Chinese was higher than that in Japanese. Serum lipids and lipoprotein cholesterols were measured in the adults of Chinese and Japanese. Except the serum triglycerids level in female, the total cholesterol, TG, high density lipoprotein-cholesterol and low density lipoprotein-cholesterol levels in Chinese adults were lower than those in Japanese adults (P < 0.001). Since cholesterol is the major predisposing factor for coronary heart disease and the results of our study show that a high carbohydrate and low fat diet can be effective in lowering the cholesterol level in blood it will be of interest to see which kind of oriental dietary may be a preventive against coronary heart disease.
This study combined the use of cephalometrics and overnight polysomnographic monitoring to analyze the effects of a dental appliance on airway, sleep and respiratory conditions in 10 patients with obstructive sleep apnea. The findings indicated that horizontal and vertical mean changes in mandibular position while the appliance was worn were 1.73 mm and 9.30 mm, respectively, the mean superior airway space increased by 2.80 mm (P < 0.01), while the mean middle airway space increased by 6.75 mm (P = 0.01), the inferior airway space, however, didn't change significantly when the appliance was worn. The average Apnea Index decreased by 15.98 events per hour when the appliance was worn (P < 0.01), the average Respiratory Disturbance Index decreased from 39.43 to 6.62 events per hour in 9 of 10 patients (P < 0.01, one patient didn't have recording of hypoventilation). the lowest SaO2 value increased from 73.87% to 85.50% (P < 0.01). The reduction in the rate of airway obstructive events is attributed to the effect of appliance on the orophargneal structures. The dental appliance is a conservative, successful treatment alternative that could benefit patients with obstructive sleep apnea syndrome.
Atherosclerosis (AS) is characterized by the proliferation of the smooth muscle cells (SMC) in the arterial wall. Its pathogenesis might be associated with overexpression of oncogenes in SMC. Gorden and Barrett et al found that sis mRNA level elevated in human atherosclerotic plaques 5-12 fold above level present in normal artery. But the transcriptional expression of c-fos, c-myc, c-jun, H-ras, v-erb-B oncogenes and Rb antioncogene in atherosclerotic lesion has not yet been reported. A study on these oncogenes and Rb gene expression in artherosclerotic lesions in rabbits fed on high cholesterol diet were assayed by the dot blot hybridization using alpha-32P-labelled oncogenes and Rb gene fragments as the probes. After fed with the high cholesterol diet for six months, the plasma cholesterol levels in AS rabbits were significantly increased (1300 +/- 240 mg/dl vs 67.1 +/- 11.5 mg/dl). The atherosclerotic plaques covered 91% +/- 11% of the intimal aortic surface of aorta thoracalis. The results showed that the atherosclerotic plaques contained 3-4 fold more v-sis, c-fos and c-myc mRNA (P < 0.01), 2 fold more c-jun and H-ras mRNA (P < 0.01), and less Rb mRNA (P < 0.05) than those in the normal aortic arteries. But the expression of v-erb-B gene in atherosclerotic plaques remained unchanged. These results indicate that the abnormal expression of v-sis, c-myc, c-fos, c-jun, and H-ras oncogenes and Rb antioncogene may play an important role in arterial SMC proliferation and pathogenesis of atherosclerosis.
The function of temporor-mandibular joint in unilateral cleft lip and palate (UCLP) palients with crossibite was studied in this paper. 29 UCLP patients with crossbite were examined clinically and with Mandibular Kinesiography and X-ray. The results were as bellow (1) Insidence of TMJDS in UCLP patients with crossbite was 75.8%. (2) The condyle of 17.8% patients moved distally and 35.7% of patients moved distally asymmetry. (3) The distance of mandibular border movements in cleft patients were in normal range. We conclude that insidence of TMJDS in UCLP patients were high and we should take it into consideration in the orthodontic treatment.
Quantitative determination of guanfu A in Radix Aconiti Coreani before and after processing has been made by dual-wavelength TLC-scanning. The results show that the content of guanfu A is about 0.144% before processing, and 0.106%-0.12% after steam processing (n = 4), which is greatly higher than other processed products. The average recovery rate is 97.64% (n = 5).
The decoction of Cynanchum glaucescens and the ethanol extract of C. stauntonii show significant antitussive and expectorant actions. The decoctions of C. stauntonii or C. glaucescens have antiasthmatic and anti-inflammatory effects. The decoction of C. atratum has some expectorant effect but no antitussive or antiasthmatic actions. On the other hand, the decoction of C. versicolor cannot relieve cough nor sputum. The results indicate that both C. atratum and C. versicolor cannot be used as C. glaucescens or C. stauntonii.
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The arterial smooth muscle cells (SMC) are the predominant type of cells in atherosclerotic lesions, and their proliferation plays an important role in the process of AS genesis. We established the primary culture and sub-culture method for human arterial SMC and observed the effects of LDL, VLDL, HDL, OX-LDL, OX-VLDL and OX-HDL on the morphological appearance and phenotype of cultured human arterial SMC. The results revealed that the cells cultured in the medium containing OX-LDL, OX-VLDL and OX-HDL (25 micrograms/ml) became more irregular with long finger-like projects and lacked a bipolar shape, and the characteristic "hills" and "valleys" disappeared. LDL and VLDL also had the influence but in smaller degrees. HDL did not have any effect. The SMC cultured in the presence of OX-LDL (25 micrograms/ml) had less myofilaments and more endoplasmic reticulua, Golgi and mitochondria in cytoplasm compared with the cells in control group under electronmicroscope. These results suggest that the atherogenic role of LDL, VLDL, OX-LDL, OX-HDL, and OX-VLDL are closely related to their stimulating effects on the modulation of phenotype of arterial SMCs from "contractile" towards "synthetic".
In this research, we used the Gunne's spectrophotometry method to measure the masticatory efficiency in 30 skeletal Class III patients and in 55 normal people. After groups comparing and step wise-regression analysis, we found that masticatory efficiency in Class III malocclusion group was much lower than that in normal occlusion group, and the masticatory efficiency in Class III malocclusion was about 60% of that in normal peoples. Masticatory efficiency in male was higher than that in female.
The primary culture of human arterial smooth cells (SMC) was performed successfully using the primary-explant method. The cells formed "hills and valleys" characteristic of SMC; the myofilament bundles were observed in the cytoplasm of the cells under an electron microscope and the cells were stained red with Ma's method. The growing character of 35th passage SMC kept unchanged. In addition, some problems concerning the culture of human arterial smooth muscle cells are discussed.
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In the present study, hypertriglyceridemia was induced by feeding S. D. rats with high carbohydrate diet (carbohydrate accounting for 80% of total calorie) for 5 days. Rat liver parenchymal cells (PC) and non-parenchymal cells (NPC) were prepared by collagenase method. Human plasma LDL, VLDL and HDL were isolated by density gradient ultracentrifugation method. 125I-LDL was labelled by ICI method. 125I-LDL binding to rat liver PC and NPC were measured by Goldstein and Brown's method. The results showed that both rat liver PC and NPC had LDL receptors to bind, uptake and degradate 125I labelled human plasma LDL. The Bmax of 125I-LDL binding to NPC was 7-fold higher than that of PC (P < 0.01), but the Kd values remained unchanged. The Bmax of 125I-LDL binding to liver NPC from hypertriglyceridemic rats was significantly higher than that of NPC from the normal diet (carbohydrate accounting for 60% of total calorie) rats (435.4 + 100.0 vs 307.1 +/- 76.8 ng/mg cell protein, n = 6, P > 0.05), but there was no difference in Kd between the HTG rats and normal rats (18.1 +/- 4.1 vs 17.2 +/- 4.0 micrograms/ml n = 6, P > 0.05). These results suggest that the increase in fractional catabolic rate of LDL in patients with hypertriglyceridemia reported by Vega and Grundy might be induced by the increase in number of LDL receptor on liver non-parenchymal cells.
The water extract of Radix Cynanchi Atrati used as intraperitoneal injection has been proved to have an obvious antifebrile++ effect on rat fever caused by 15% yeast suspension hypodermic injection as well as a significant anti-inflammatory effect. But the antiferbrile effect of its ethanol extract is not clear.
Fifteen unilateral crossbite patients of primary and mixed dentition with mandibular asymmetry were treated by transverse expansion using removable appliance. Posteroanterior cephalometric analysis was utilized before and after treatment. The results suggested that after the correction of unilateral crossbite, the deviation of midsagittal mandibular total lenth decreased significantly. According to this study, early treatment of unilateral crossbite is indicated.
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In this research, we compared the swallowing pattern in 33 normal occlusion adults with that in 29 skeletal Class III malocclusion adults, using computerized videofluoscopy. We found that: 1) in skeletal Class III malocclusion patients, the tongue, the hyoid bone and the mandible were in much lower position than those in normal people at postural position. The gap separation between the upper and lower lip was much larger. So was the space between the upper and lower molars. During swallowing, the tongue tip moved upward and backward, and continually moved back along with the backward movement of the tongue dorsum. This was the typical tongue retraction swallowing pattern in Class III malocclusion. The lips kept separation during deglutition, so did the molar region. 2) Abnormal swallowing pattern in skeletal Angle Class III patients was the adaptable change with the dentoalveolar disharmony, while the long time abnormal swallowing could change dentoalveolar structure.