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M G Aĭrapetiants

Publications and source records attributed to M G Aĭrapetiants.

41 records · Page 3Linked to original sources
PubMedDate not supplied

[The prophylactic effect of negatively charged air ions in acute stress in rats with different typological behavioral characteristics].

Typological characteristics of behaviour of 63 male white rats weighing 200-250 g were estimated by their locomotion in the open field. Acute stress was induced by putting the rats into narrow tubes for 1 h. Prior to the experiment, the rats were exposed to the air ions produced by Chizhevskiĭ air ionizer ("Elion-132") for 2 h daily within a week. It was found out that the expression of separate pathological stress-induced changes depended on typological characteristics of rats. The air ions were shown to prevent completely the development of physiological changes caused by acute immobilization, including arterial pressure increase, gastric mucosa injuries (erosions, haemorrhage), changes in respiratory enzyme activity (succinate dehydrogenase and NADH-dehydrogenase) in brain cells, cardiac and adrenal mass increase in rats with the active type behaviour.

Acute Disease↗
PubMedDate not supplied

[The participation of cerebral hypoxia in the pathogenesis of neuroses (a new concept)].

The data are presented concerning the state of vascular brain system during experimental neurosis in Wistar rats, the intricate cerebral hemodynamical disturbances, shifts in activity of the crucial enzymes of the mitochondrial respiratory chain, and activation of the lipid peroxidation processes. The positive results on treatment of the experimental and clinical neuroses with antioxidants which have antihypoxic properties are presented. Results on increase of resistance to stress in rats under the influence of negatively charged air ions with expressed antihypoxic are discussed. The general outline is given of the molecular neurochemical processes which accompany the development of neurotic diseases as well as of reversal of these processes due to the antioxidant therapy. The concept concerning the cerebral hypoxia in neuroses is based on the obtained evidence. This concept opens the principally novel pathogenetical approaches to treatment and prevention of these diseases.

Adult↗
PubMedDate not supplied

[The behavioral characteristics of rats induced by partial degeneration of the hippocampal cholinergic neurons].

The effects of intraventricular administration of ethylcholine aziridinium ion (AF64A) were studied in male Wistar rats. Bilateral injections of AF64A (3 nm/3 mcl) reduced the reactions to biological alarm signal and produced a decrease in the open-field activity 3 weeks after this lesion. The lesioned rats also displayed deficit in retention of a passive avoidance task.

Animals↗
PubMedDate not supplied

[The action of the neurotoxin AF64A on the reactions of neuroticized rats].

The effects of intracerebroventricular administration of ethylholine aziridinum ion (AF64A) were studied in neuroticized male Wistar rats. The cholinotoxin was bilaterally injected in the dose of 3 nmol. AF64A produced a significant decrease in arterial pressure and activity of respiratory enzymes succinate dehydrogenase and NADH-dehydrogenase in hippocampus and motor cortex. Increase in the local blood flow in the hippocampus and motor cortex had a compensatory character.

Animals↗