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Biomedical subjects

M G Glezer

Publications and source records attributed to M G Glezer.

50 records · Page 3Linked to original sources
PubMed1980

[Changes in blood pressure and cardiac contraction frequency in diabetes mellitus patients in an orthostatic posture and under physical load].

The author studied the character of changes in arterial pressure (AP) and rate of cardiac contractions (RCC) in the orthostatic position and during physical exercise in 93 patients with diabetes mellitus. A considerable decrease in systolic AP was noted in the orthostatic position, particularly in the first minutes and in individuals of the older age group, while the diastolic pressure showed no essential changes. The RCC at rest and its gradual increase in the orthostatic position were higher in patients with diabetes mellitus than in healthy individuals. In patients with neuro- and nephropathy the diastolic and systolic AP decreased in the orthostatic position; the RCC in patients with neuropathy hardly changed in this case. The capacity for physical exertion in diabetic patients, particularly in those with neuropathy was low. The degree of growth in RCC and in systolic AP was less in the patients than in healthy individuals. The increase in systolic AP and RCC in patients with neuropathy, however, was greater than that in the other groups of patients. The disorders in cardiovascular regulations which were revealed in some of the patients suggest that affections of the vegetative nervous system may also develop in the absence of affection of the peripheral nerves.

Blood Pressure↗
PubMed1980

[Bioavailability of digoxin tablets in cardiac insufficiency patients].

The bioaccessibility of Soviet produced digoxin tablets in elderly patients with cardiac insufficiency was studied. It is shown that in absolute bioaccessibility (62%) and other biopharmaceutic indices digoxin tablets made in the Soviet Union are equivalent to lanoxin tablets of the Burroughs Wellcome firm which are accepted by the USA FDA as the bioaccessibility standard. Equations fitted within a two-part mathematical model satisfactorily describe the changes in blood serum digoxin concentration in oral medication and in intravenous administration.

Aged↗
PubMed1980

[ECG study of diabetes mellitus patients at rest, in an orthostatic posture and under physical load].

ECG changes at rest were noted in half of 87 patients with diabetes mellitus. Negative ECG changes in orthostatics were observed in 2/3 of the patients. The rate of the changes depends upon the heart rate increase, reflecting higher sympathetico-adrenal activity. The results of potassium salt application point to metabolic disorders in the myocardium of patients with diabetes mellitus. The orthostatic test performed during the course of treatment with potassium salt may serve as an index of efficiency and stability of the therapy conducted. ECG changes under physical exercise were observed in 14 of 54 patients, only in 4 of them the changes were tupical of coronary heart disease. Comparison of exercise tolerance, orthostatic and potassium salt tests which reveal cardiac damage of different nature, suggests that myocardial changes in patients with diabetes mellitus are mostly conditioned by the development of metabolic changes.

Coronary Disease↗