A pharmacoeconomic intrapatient comparison of Sandimmune capsules and Sandimmune oral solution in kidney transplant recipients.
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Biomedical subjects
Publications and source records attributed to M Gagne.
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Examined cardiovascular and testosterone responses of dominant and submissive women to an acute stressor involving contested dominance. Twenty (10 dominant, 10 submissive) university students rated their dominance to a predefined reference group, participated in a task that involved debating with a trained technician, and were continuously provided with bogus feedback throughout the task concerning biochemical substances in their blood that purportedly covaried with dominance. Covariance analyses revealed that dominant women were much more reactive to the stressor in several cardiovascular parameters than those classified as submissive. Serum testosterone did not vary as a function of the experimental manipulation, and at each measurement point, dominant and submissive subjects had essentially identical serum levels of this hormone. Interestingly, however, baseline testosterone for the dominant group was related to changes in systolic blood pressure (i.e., gain scores computed as task response minus baseline values).
We examined the cardiovascular and testosterone responses of dominant and submissive males to an interpersonal challenge of dominance status. Twenty college-aged students rated their dominance to predefined reference groups and engaged in a debate against a trained technician. Throughout the task, they were continuously given false feedback regarding biochemical substances in the plasma that purportedly covaried with dominance. Covariance analyses revealed that the task created greater heart rate reactivity and lower testosterone levels on the part of submissive subjects when contrasted with those scoring high in self-reported dominance. Interpretation of these data emphasizes the importance of an interactionist perspective in research dealing with acute stress reactivity.
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We have developed a rapid, sensitive and inexpensive method to quantify DNA in crude extracts or PCR reaction products using daunorubicine fluorescence quenching. We obtained a linear standard curve from 4.7 ng to 600 ng DNA and no interaction was observed in the presence of proteins.