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Biomedical subjects

M Ghinelli

Publications and source records attributed to M Ghinelli.

6 recordsLinked to original sources
PubMed1990

[Mexiletine in patients with progressive infarction and reduced ventricular function: anti-arrhythmic efficacy and hemodynamic effects].

Reduced left ventricular function and ventricular arrhythmias are the main risk factors associated with sudden death in patients with previous acute myocardial infarction. Antiarrhythmic therapy may have side-effects on myocardial contractility and sometimes makes the arrhythmia itself worse, especially when the pump function is seriously compromised. The aim of this study was to evaluate the efficacy of oral mexiletine as well as any modifications in left ventricular function by means of ambulatory ECG monitoring and angiocardiography with Tc 99m, at rest and after the handgrip test, in 20 patients with previous myocardial infarction and ventricular arrhythmias who were grouped into NYHA class II and class III. The mexiletine therapy lasted three weeks. Both classes showed a significant decrease in the number of ventricular extrasystoles/hour and in the number of couples (p less than 0.01). The decrease in the number of the ventricular runs proved to be higher in the general analysis (p less than 0.01) than in each NYHA class (p less than 0.05). At the end of the study, significant modifications were not observed either in the end-diastolic and end-systolic volumes, or in the ventricular ejection fraction.

Aged↗
PubMed1986

Myocardial infarction and histamine release.

On the basis of previous data suggesting the involvement of cardiac histamine in ischemic heart disease (IHD), we evaluated plasma histamine (H) and creatine-kinase isoenzyme (CK-MB) level in cardiac and healthy subjects. 20 patients with acute myocardial infarction (AMI) (10 developing AMI in Hospital, thus making possible the detection of plasma H level before acute event), 10 patients with IHD not developing AMI and 10 presumably healthy subjects were admitted to the study. 15 of all patients with AMI showed a correlated H and CK-MB trend during AMI reaching the highest peak 24 hours after onset of pain. 7 of the patients with IHD who developed AMI in Hospital showed a slightly higher plasma H level, before AMI, than those with IHD who did not develop AMI. A possible role of histamine in the pathogenesis of AMI is discussed.

Coronary Disease↗
PubMed1982

Solitary chondromas of the long bones of the hand (results in 18 cases treated with autoplastic bone grafts).

Eighteen cases are reported of solitary chondroma of the long bones of the hand treated by curettage and packing with autoplastic grafts of spongy bone. The preferred localisation was in the three ulnar rays and in the metaphyseal zones in the neighborhood of the growth cartilage. In the younger patients the site was more often in the diaphysis; in the older patients, almost exclusively meta-epiphyseal. The diagnosis is usually made fortuitously as a result of a pathological fracture (61 per cent of the cases investigated). The results, assessed at an average of two and a half years after operation, were consistently excellent. They demonstrate that, in practice, any variety of this condition can be successfully treated by this method.

Adolescent↗