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Myocardial infarction and histamine release.

F Zaca·M S Benassi·M Ghinelli·M Trianni·R Vaccarino·E Malavolta·M Muratori·S Lenzi
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Abstract

On the basis of previous data suggesting the involvement of cardiac histamine in ischemic heart disease (IHD), we evaluated plasma histamine (H) and creatine-kinase isoenzyme (CK-MB) level in cardiac and healthy subjects. 20 patients with acute myocardial infarction (AMI) (10 developing AMI in Hospital, thus making possible the detection of plasma H level before acute event), 10 patients with IHD not developing AMI and 10 presumably healthy subjects were admitted to the study. 15 of all patients with AMI showed a correlated H and CK-MB trend during AMI reaching the highest peak 24 hours after onset of pain. 7 of the patients with IHD who developed AMI in Hospital showed a slightly higher plasma H level, before AMI, than those with IHD who did not develop AMI. A possible role of histamine in the pathogenesis of AMI is discussed.

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Coronary DiseaseCreatine KinaseFemaleHistamine ReleaseHumansIsoenzymesMaleMiddle AgedMyocardial InfarctionJournal Article

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F Zaca, M S Benassi, M Ghinelli, M Trianni, R Vaccarino, E Malavolta, M Muratori, S Lenzi. 1986. Myocardial infarction and histamine release.. https://doi.org/10.1007/bf01988036

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