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Biomedical subjects

M Gociu

Publications and source records attributed to M Gociu.

At least 19 recordsLinked to original sources
PubMed1975

Cytoenzymochemical effects of some antiblastic drugs and prediction of response to chemotherapy in acute leukemias.

Over 20 cytoenzymochemical tests were carried out in 152 patients with different types of acute leukemia to estimate the effects of some antiblastic drugs such as L-asparaginase, Purinethol, Methotrexate, Endoxan, Vinchristine, Cytosine Arabinoside a.o. The patients selected for the study were carefully examined before treatment at different moments during and/or at the end of the treatment. The effects of these drugs on the blast cells were mild when the cellular populations had a low rate of nucleic acid synthesis, high glycogenic score and high amounts of lipids or an important oxidative enzymatic activity. The enzymatic prediction tests: the acid phosphate deviation test and the succinic dehydrogenase inhibition test including the variant suggested by some of the authors - the latic dehydrogenase inhibition test - gave satisfactory results only in certain cases of acute leukemia.

Acid Phosphatase↗
PubMed1975

Clinical evolution, histologic type and general lymphographic picture in Hodgkin's disease.

In 88 patients with Hodgkin's disease the clinical value of the general lymphographic picture (lymphodynamic aspects plus nodal patterns) is analysed. The survival times are also reported according to the different pre- and postlymphographic evolution. Histologic types and prelymphographic therapy are correlated with the general lymphographic picture. The predominance of foamy and/or spotty lymphographic patterns of lymph nodes as well as the lymphatic blockages have a severe prognosis (mean intervals between lymphography and exitus 8.3 and respectively 6.2 months). In such cases lymphocytic depletion represents the most frequent histologic type.

Hodgkin Disease↗