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Biomedical subjects

M Gociu

Publications and source records attributed to M Gociu.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

Comparative cytogenetic and cytologic study in malignant lymphomas.

The possibility of a cytogenetic-cytologic correlation with implications in the diagnosis, evolutivity and prognosis of malignant lymphomas was studied. Cytogenetic investigations were carried out comparatively in the lymph node and spleen lymphoid cells from 25 patients with malignant lymphomas and in normal subjects or patients with malignant tumors. The dominant malignant cellular type was found to correspond genotypically to the abnormal clone. In lymphomas with more differentiated cells the chormosomal abnormalities were limited to a single chromosomal group, while in those with less differentiated cells there were many clonal chromozomal abnormalities. The pathogenic significance of an extra-chromosome in the C-group (observed in most of the cases) is discussed.

Chromosome Aberrations↗
PubMedDate not supplied

Hypotheses on the role of chromosomal changes in leukemias. Application of the Weibull distribution function.

Investigations were carried out in 38 patients with acute leukemias or with chronic myeloid leukemias in the blast phase and a correlation was made between the cytogenetic aspect and the survival time. The interpretation of results was made by the Weibull distribution function. It was mathematically demonstrated that in the leukemic patients with chromosomal aberrations there is a preclinical period of over 40 months necessary for the formation of these anomalies. Chromosomal aberrations, the absence of mitoses and age over 70 proved to be aggravating factors in the diseases investigated.

Adolescent↗