Biomedical subjects
M H Friedlaender
Publications and source records attributed to M H Friedlaender.
Some unusual nonallergic causes of giant papillary conjunctivitis.
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Complications of antimalarial therapy.
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Effect of minimal antibiotic treatment on bacterial keratitis.
We studied the effect of minimal antibiotic therapy on pseudomonas keratitis in rabbits. Both corneas of 12 rabbits were infected with Pseudomonas aeruginosa and treated 24 and 48 h later with two drops of tobramycin or placebo. Corneal infections in antibiotic- and placebo-treated groups were comparable in appearance 24 and 48 h after inoculation. However, bacterial recovery was significantly less in eyes treated with minimal antibiotic therapy (p = 0.009). Although negative cultures were obtained from 11 of 12 antibiotic-treated eyes, bacteria could be recovered from eight of these culture negative corneas when corneas were ground and cultured. These studies suggest that minimal antibiotic therapy may impair bacterial recovery without completely eradicating live organisms.
Conjunctival provocative tests: a model of human ocular allergy.
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Vernal keratoconjunctivitis and trachoma.
Both vernal keratoconjunctivitis and trachoma affect young people, occur in hot, dry climates, and have a predilection for the limbus and upper tarsal conjunctiva. These two conditions may occur simultaneously and present the ophthalmologist with a diagnostic and therapeutic dilemma.
Laboratory diagnosis of the allergic eye.
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Contact allergy and toxicity in the eye.
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Conjunctival provocation tests and naturally occurring allergic conjunctivitis in clinical trials.
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Immunologic aspects of diseases of the eye.
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Endophthalmitis of drug abuse.
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Leukotrienes in the aqueous humor of patients with uveitis.
Utilizing chromatographic and radioimmunoassay techniques, we measured the concentration of leukotriene (LT) B4 and LTC4/D4/E4 in the aqueous humor of 14 patients with uveitis and seven patients undergoing penetrating keratoplasty or routine cataract extraction. Leukotriene B4 was detected in 11 of 14 patients with uveitis (mean, 0.96 pmole/mL), and LTC4/D4/E4 was found in 12 of 14 patients with uveitis (mean, 2.0 pmole/mL). In the control group, LTB4 was detected in six of seven patients (mean, 0.57 pmole/mL), and LTC4/D4/E4 was found in six of seven patients (mean, 1.9 pmole/mL). Leukotriene levels did not correlate with clinically assessed aqueous cell and flare. Mean levels of LT in patients with uveitis receiving corticosteroids were nearly double those found in non-steroid-treated patients. Despite apparent differences in LT levels, none of the above differences reached statistical significance.
Ocular allergy. Scratching the surface of the red eye.
The primary care physician may be the first physician to evaluate conjunctivitis caused by allergy or infection. A proper diagnosis can usually be made by asking the patient a few simple questions. Treatment with eyedrops is not always necessary. When the diagnosis is uncertain, treatment is best withheld, because "shotgun" therapy is seldom beneficial. Corticosteroid eyedrops are rarely necessary. When they are used, the physician must monitor intraocular pressure and examine the eye with a slit-lamp microscope for signs of cataract and opportunistic infection. Because there is a tendency to overtreat eye disorders, improvement of ocular inflammation is more often accomplished by stopping drug administration than by starting it.
Allergic disorders of the peripheral cornea.
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