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Biomedical subjects

M Hamilton

Publications and source records attributed to M Hamilton.

At least 163 records · Page 9Linked to original sources
PubMed1982

Intracellular transport of the transmembrane glycoprotein G of vesicular stomatitis virus through the Golgi apparatus as visualized by electron microscope radioautography.

The intracellular migration of G protein in vesicular stomatitis virus-infected cells was visualized by light and electron microscope radioautography after a 2-min pulse with [3H]mannose followed by nonradioactive chase for various intervals. The radioactivity initially (at 5-10 min) appeared predominantly in the endoplasmic reticulum, and the [3H]mannose-labeled G protein produced was sensitive to endoglycosidase H. Silver grains were subsequently (at 30-40 min) observed over the Golgi apparatus, and the [3H]mannose-labeled G protein became resistant to endoglycosidase H digestion. Our data directly demonstrate the intracellular transport of a plasmalemma-destined transmembrane glycoprotein through the Golgi apparatus.

Animals↗
PubMed1982

Consultation to line staff and its impact on the care of chronic patients.

This study was carried out to determine whether long term chronic deteriorated patients could be taught skills in activities of daily living by therapy aides to improve their quality of life in the hospital. It was designed as a controlled trial comparing active intervention in the experimental wards with routine nursing care in the control wards. The results showed that, even in such a short period as 3 months, active treatment produced results which were statistically significantly better than the controls. It is concluded that mental hygiene therapy aides, given adequate support and encouragement, can make measurable and observable improvements in the behavior of long term patients. The implications of the results are considered.

Activities of Daily Living↗
PubMed1982

A comparison of triprolidine and cyclizine on histamine (H1) antagonism, subjective effects and performance tests in man.

1 The effects of triprolidine and cyclizine on the histamine skin response, performance tests and subjective effects were examined in a controlled, double-blind study in eight healthy volunteers. 2 Triprolidine was considerably more potent that cyclizine in inhibiting the skin response to histamine. Significant inhibition of flare size occurred at 1, 2 an 4 h after triprolidine 2.5 mg. A smaller but significant reduction occurred at 2 and 4 h after cyclizine 100 mg but not after the 50 mg dose. 3 Cyclizine 100 mg produced a significant increase in reaction time at 4.5 h compared with lactose. Smaller though non significant increases followed triprolidine and cyclizine 50 mg. 4 Subjective effects were seen only after cyclizine 100 mg when subjects were significantly more drowsy, feeble, muzzy, lethargic and dreamy than after lactose dummy. No significant changes followed triprolidine 2.5 mg or cyclizine 50 mg. 5 It was concluded that while cyclizine has antihistamine properties, these are weak compared with triprolidine, and are not seen with doses sufficiently low to avoid central nervous system impairment.

Adult↗
PubMed1982

The effect of treatment on the melancholias (depressions).

The results described are based on data from 47 male and 83 female patients randomly assigned to treatment with imipramine or phenelzine in an open trial. All were fresh (untreated) cases diagnosed as suffering from depressive illness (melancholia). They were rated before treatment and 2 and four months later. Imipramine did not give results which were significantly better than phenelzine. With both drugs it was found that patients had done either very well or very poorly at follow-up, i.e. the distribution of scores was U-shaped (or bimodal at the least). The 55 men and 90 women who were unsuitable for treatment with drugs or who had failed to respond to such treatment were given a course of ECT and followed-up at corresponding intervals. The improvement after ECT was better than with drugs and the distribution of scores is quite different. An earlier series of male patients treated with ECT in the pre-drug days did not show as good a response to the treatment.

Adolescent↗
PubMed1982

Satisfaction in lesbian relationships.

A questionnaire study of 127 lesbians tested hypotheses from the social psychological literature about factors associated with relationship satisfaction. In general, lesbians in the sample reported fairly high levels of satisfaction and love in their current relationship. Results indicated that satisfaction was more strongly related to characteristics of the relationship itself than to the individual attitudes or background characteristics of individual partners. In particular, greater satisfaction was associated with equality of involvement and equality of power in the relationship. Some evidence was also found that similarity was associated with greater satisfaction.

Adolescent↗
PubMed1982

Laboratory differentiation of hypercalcemic patients.

We studied the biochemical discrimination of primary hyperparathyroidism from other causes of hypercalcemia. This potentially serious disorder is readily remedied, and because recent work has suggested that even very mild cases in elderly people derive substantial benefit from surgery, the correct diagnosis is crucial. A discriminant function is derived that maximizes the use of data that are readily available from general hospital laboratory; application of the Hamilton "T score" system simplifies its interpretation. We conclude that the best use of this formula is as a negative discriminant, to identify some non-hyperparathyroid cause of hypercalcemia, and also as a partial positive discriminant, to identify some cases of primary hyperparathyroidism. We review previous such discriminants and consider the reasons why they have been less successful.

Albumins↗
PubMed1981

Treatment of chronic patients by therapy aides: a pilot project.

A three-month pilot project was devised to test the effectiveness of treatments designed by therapy aides for improving the daily living skills of long-term chronic psychiatric patients. The study was conducted on two male and two female wards; one male and one female ward were chosen for experimental treatment, the other two as controls. Patients behaviors were rated by a nurse or therapy aide and by one of the investigators both before and after the trial began. Ratings by nursing staff-showed no over-all effect of treatment on male and female patients combined but significant improvement among the males. Investigators rated both male and female treatment groups as significantly improved. The results suggest that improvements in behavior can be achieved using procedures that are much simpler and less costly than formal behavior modification programs.

Allied Health Personnel↗
PubMed1980

Ureteric stone. When do we need to intervene?

This paper reports the experience of one urologist reviewing a series of 210 patients with ureteric stone over a 12-year period. The study suggests that with care and patience, more than three quarters of these calculi will pass without surgical intervention. The importance of stone size and site as giving the best prognosis of expected outcome is demonstrated, and it is suggested that the classical indications for operation should be reviewed.

Humans↗
PubMed1980

Rating depressive patients.

Various methods can be used for assessing symptoms of depression. These include check lists, scales for patient self-rating and rating scales completed by trained professional observers. Each technique has its special place in psychiatric research and each technique has its own strengths and weaknesses. A common concern on the part of psychiatrists is the fear that numerical assessment is dehumanizing. This is not the case as this method is intended only to make statistical analysis convenient and in no way reduces the concern for the subject's individuality. A commonly used depression rating scale, the Hamilton, has been extensively used in clinical trials of antidepressant drugs and for other purposes in clinical research. The various items of that scale are discussed and the system of rating explored from a clinician's point of view.

Depressive Disorder↗