PubMed Health⌕ Search

Biomedical subjects

M Hannuksela

Publications and source records attributed to M Hannuksela.

At least 91 records · Page 5Linked to original sources
PubMed1983

Prostaglandins in contact urticaria induced by benzoic acid.

To study the role played by prostaglandins (PGs) in contact urticaria, concentrations of 13,14-dihydro-15-keto-PGF2 alpha, 6-keto-PGF1 alpha, and thromboxane B2, the stable metabolites of PGF2 alpha, prostacycline and thromboxane A2 were measured by radio-immunoassay of the fluid taken from suction blisters in 11 patients. The blisters were raised on contact urticarial reactions induced by benzoic acid. The effect of peroral indomethacin on contact urticaria from benzoic acid was studied in a further 14 dermatological patients. The levels of these prostanoids in the blister fluid of urticarial skin did not differ from those derived from control blisters raised on apparently normal skin. Premedication with indomethacin, 50 mg t.i.d., completely prevented contact urticarial reactions to benzoic acid in all patients.

Adolescent↗
PubMed1981

Immediate skin test reactions to spices.

Scratch tests with common spices were performed in 1,120 atopic and 380 non-atopic patients. Positive skin test reactions were seen almost exclusively in atopics. Curry and paprika produced reactions most frequently, and when the components of curry were tested separately, coriander, caraway, cayenne and mustard were responsible for the vast majority of the skin reactions. A high correlation between positive skin test reactions to spices, especially to curry and its components, and tree pollens, fruits and vegetables was demonstrated, suggesting that there may be a group of cross allergies. Clinical symptoms from ingested spices were noticed by five patients. When small amounts of spices were spread on the oral mucosa, local reactions, especially in the mouth and nasopharynx, were found in 14 out of 35 unselected patients with positive skin test reactions. Peroral challenges with spices in gelatin capsules were negative in 20 nonselected patients.

Adolescent↗
PubMed1981

Lichen picker's dermatitis (Cladonia alpestris (L.) Rab.).

The frequency and immunological background of dermatitis occurring in lichen pickers during the 3- to 4-month picking season were studied in a small community in northern Finland. Thirty of 164 lichen pickers had suffered from dermatitis at least on the fingers and the dorsa of their hands, and many of them also had dermatitis on their forearms, faces, etc. Fifteen of them were subjected to epicutaneous and photo-epicutaneous testing with crushed Cladonia alpestris (L.) Rab. and some fractions of it. Allergic contact reactions were seen in nine subjects, three of whom also had positive photo-epicutaneous test reactions from lichen allergens. No immediate reactions were seen in scratch or scratch chamber tests with crushed Cl. alpestris or with its alcoholic extract.

Adult↗
PubMed1981

Long-term local trioxsalen photochemotherapy in psoriasis.

Good results were achieved in psoriasis with trioxsalen baths and UVA in 92% of 158 patients during initial treatment and in 83% of 139 patients during long-term treatment. Grade I-II local burns were encountered in about 7% of the patients. In addition, itchy skin pain was experienced by 2 patients, and in both of these the therapy was discontinued. Neither skin malignomas nor other serious side effects were seen.

Administration, Topical↗
PubMed1981

Clinical trial of a potent non-halogenated topical steroid, Budesonide.

In a double-blind, randomized multi-centre study, 116 patients with psoriasis have been treated for 1-3 weeks with budesonide ointment (Preferid, Draco/Tika; a subsidiary of AB ASTRA), a new non-halogenated topical steroid. In a series of 11 patients a 0.025% budesonide ointment was significantly superior to placebo. In a second series, of 54 patients, a 0.025% fluocinolone acetonide ointment (Synalar, ICI). In a third series, of 51 patients, a 0.010% budesonide ointment was compared with 0.025% fluocinolone acetonide ointment. No statistically significant difference between these two preparations was found to exist. No adverse reactions were observed.

Administration, Topical↗
PubMed1981

Delayed contact allergies in patients with photosensitivity dermatitis.

Delayed contact allergies and the clinical course of the skin disease were investigated in 14 patients with photosensitivity dermatitis/actinic reticuloid and 145 patients with polymorphous light eruption type eczema. Hypersensitivity to chromium and rubber chemicals was encountered in photosensitivity dermatitis more often than in polymorphous light eruption eczema and in the comparison series of 1714 patients with other types of dermatitis. In the eczema group, delayed contact allergies to chromium, rubber chemicals, neomycin, clioquinol, balsam of Peru, fragrance and colophonium were more frequent than in the comparison group, suggesting that at least delayed contact allergy to chromium and rubber chemicals may be of significance in the development of photosensitivity in many patients who suffer eczematous reaction to sunlight.

Adolescent↗
PubMed1981

[Contact allergy].

Explore the source record for details and available documents.

Dermatitis, Atopic↗