[Causes of death in patients after the surgical treatment of esophageal cancer].
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Biomedical subjects
Publications and source records attributed to M I Davydov.
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123 lung carcinoids were studied, 32 of them electron-microscopically. Ultrastructural features were evaluated with the use of multivariate analysis. The most informative ultrastructural features were the following: correlation between differentiated and undifferentiated cells, the number of cytoplasm organoids including endocrine granules, degree of nuclei polymorphism and their size, specialized contacts, mitoses. Up to 18% of carcinoids, on the average, need ultrastructural verification of the anaplasia degree, this percentage increasing to 27.2% in atypical carcinoids. The above ultrastructural criteria allow to specify malignant potential of carcinoids, facilitate differential diagnosis and make their prognosis.
In operation for esophageal cancer the authors distinguish amputation and rehabilitation stages. Analysis of survival rate has shown that extended esophageal resections are preferable to typical resections. The differences are significant both in locally limited cancer and cancer with lymphogenous metastases. One-stage esophagoplasty is advisable, since after Dobromyslov-Torek's operation multistage esophagoplasty could be completed only in one-third of the patients due to recurrence of the disease and their general weakness. In Lewis' and Garlock's one-stage operations it is preferable to perform an "end-to-side" anastomosis with immersion of the first line of anastomotic sutures and the adjacent esophageal part into the anterior gastric wall. Postoperative mortality for Lewis' and Garlock's operations was 14.7% and 8.3%, respectively. Combined operations are justified only when one-stage esophagoplasty is performed.
The 30 years experience includes 293 esophageal resections for carcinoma, completed with esophagogastrostomy at the thoracic or cervical level. Resections were performed according to the method of Garlock (73), Lewis (178), and Dobromyslov-Torek (36). This paper compares isoperistaltic esophagoplasty with whole or resected stomach (257) and antiperistaltic esophagoplasty with a tube from the greater gastric curvature (36). We will assess the choice of an esophageal substitute, the creation of esophagogastric anastomosis, and the functional consequences of surgical intervention.
First clinical experience of assisted high-frequency controlled lung ventilation has been reviewed in 11 patients with esophageal cancer and acute respiratory failure developing in the early postoperative period. The technique proved effective for hypoxemia relief, with the catheter introduced into the trachea transcutaneously or intranasally. High-frequency controlled lung ventilation had a positive effect on the cardiac function and oxygen transport. The technique is easily reproducible, permits adequate bronchotracheal cleansing and is well tolerated. Preservation of spontaneous respiration allows inhalation therapy and has a favourable psychological effect on the patients.
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Out of 108 patients with gastric and cardiac cancer and surgical complications, 49 were treated in the routine manner and 59 operatively. The immediate results were equal in either cases: 17 (34.7 +/- 6.8%) of 49 patients and 23 (39.0 +/- 6.35%) of 59 patients died (r = 0.46). However, to compare the results of two therapeutical policies is impossible: the magnitude of pathological changes and the severity of the patients' condition is too incomparable before a decision is made which therapeutical policy is chosen. The largest number of repeated emergency operations (22 patients) was associated with impaired hermiticity of the gastrointestinal tract. The major causes of this abnormality is esophageal anastomotic suture incompetence (2.7%) and graft necrosis (1.0%). Impaired patency in various parts of the gastrointestinal tract occupies the second place in its incidence (20 patients) for which 19 repeated emergency surgical interventions were made. Postoperative bleeding requiring repeated emergency surgical intervention occurred in 0.5%; in all cases, the bleeding was intrathoracic, chylothorax was detected in 1 patient, mediastinitis without disintegrity of the digestive tube was also noted in 1 patient, pancreonecrosis was recorded in 2 cases. Due to the introduction of extensive lymph dissection into these operations in 1990, the frequency of complications increased up to 2.1%.