Biomedical subjects

M I Filimonov

Publications and source records attributed to M I Filimonov.

At least 19 recordsLinked to original sources

PubMed1997

[The wakefulness-sleep cycle during antiorthostatic hypokinesia].

Studies on the wake-sleep cycle with participation of eight female volunteers were performed before, during, and after a 120-day bed rest with the head-end of bed tilted down at 6 degrees (HDT). Methods of polysomnography and actography were applied. The test-subjects were assigned into 2 groups. Group A was prescribed to use countermeasures throughout the experiment; no countermeasures was administered by group B. Evidence of significant alteration in sleep structure at different time points in HDT is given in comparison with data about females of the control group under the conditions of everyday activity. Sleep deviations in the subjects were reordered at each of the three points of investigation and differed from those in control. HDT was shown to modify the sleep structure in experimental groups A and B. A supposition is made that under these conditions the dynamics of physical activity during night sleep had an adaptive character.

Adult↗

PubMed1997

[Features of the sleep/wakefulness cycle in long-term isolation].

The sleep/wakefulness cycle was the subject of polysomonographic and actographic studies in two experiments with isolation and confinement of six volunteer operators for 135 and 90 days. The dynamics of sleep structure was the target parameter before, during, and after the experiments. The sleep structure dynamics and changes in the motor activity differed in their directionality. At all the stages of experiments the operators' sleep structure had some unique peculiarities. Discussion is centered around the cases of shortened duration of delta-sleep and altered latent periods of specific stages. During the off-nominal situation (ONS) with 45 hour sleep deprivation polysomnographs recorded episodes of latent sleep which became more multiple during the second ONS and were combined with signs of "slow" sleep, and increases in the index of motor activity during night sleep post ONS. Hence, adaptation to changed physical and social environments is manifested by a specific functional restructurization of the sleep/wakefulness cycle.

Humans↗

PubMed1995

[Method of treatment of patients with calculous cholecystitis complicated with mechanical jaundice].

Data on the treatment of 228 patients with calculous cholecystitis complicated by obstructive jaundice are reported. Two-stage treatment was applied. In the first stage endoscopic and roentgenoendobiliary therapeutic interventions were undertaken to relieve jaundice and remove its causes. In the second stage a planned surgical operation was conducted after elimination of biliary hypertension, which consisted in cholecystectomy in the majority of patients. Such therapeutic tactics reduced mortality by half.

Cholangiopancreatography, Endoscopic Retrograde↗

PubMed1994

[Potential uses of plasma scalpel in liver and gallbladder surgery].

The article deals with the results of experimental studies and clinical experience in the use of the plasma scalpel in 25 unbred dogs and 192 patients with diseases of the liver and gallbladder. Histological studies of the hepatic tissue after treatment with the laser scalpel allowed the conclusion that such manipulations are safe. The advantages of using the device for arresting bleeding and the flow of bile from the resected hepatic areas were revealed. The accumulated experience in operations on the liver and gallbladder with a plasma scalpel made it possible to develop optimal approaches to the use of the plasma flow in resections of the liver and to suggest three methods for removal of the gallbladder. Their introduction into practice improved the intraoperative possibilities of treatment of the gallbladder bed.

Acute Disease↗

PubMed1991

[Extracorporeal lithotripsy in acute obstructive cholecystitis].

Available is pilot experience in the use of extracorporeal shock--wave lithotripsy for acute--stage management of calculous cholecystitis running with obturation of the cystic duct in the absence of complications. Crushing of the stones resulted in elimination of the duct obturation and compression of the gallbladder in 95% of the patients, the acute episode was arrested and 50% of those treated got free of the stones. These therapeutic results are promising and evidence extracorporeal lithotripsy efficiency in acute obstructive cholecystitis.

Acute Disease↗

PubMed1990

[Extracorporeal lithotripsy in cholelithiasis].

The authors describe their first experience with treatment of 46 patients with extracorporeal lithotripsy. Its high effectiveness has been shown. The method is atraumatic and harmless, there is no risk of lethal outcome. These properties allow using the method both in patients having contraindications to operation because of their critical general state and in patients who refused to be operated upon.

Adult↗

PubMed1990

[Bacteriocholia and cholic acid level in the bile in cholelithiasis].

Infection of the biliferous system in patients with cholelithiasis was shown to be the most frequent when the levels of cholic acid in bile were low. Physiological concentrations of cholic and deoxycholic acids have antimicrobial activity against organisms not adapted to the presence in bile. Outer drainage of the bile ducts was accompanied by an increase in the levels of cholic acid when at the background of outer decompression bacteria were eliminated from the biliferous system. In vitro studies revealed a synergistic antibacterial effect of cholic and deoxycholic acid combinations with cefazolin.

Bile↗

PubMed1990

[Surgery of extrahepatic bile ducts].

Explore the source record for details and available documents.

Ampulla of Vater↗

PubMed1990

[Ultrasonographic examination in the differential diagnosis of jaundice].

The results of complex examination of 352 patients with various forms of jaundice are discussed. All patients underwent ultrasonic examination (USE). Comparison of the results of USE with those of other methods of examination showed it to possess diagnostic value in patients with various forms of jaundice. The highest accuracy of the diagnosis was in patients with parenchymatous jaundice. In patients with benign jaundice as well as in those with jaundice of a neoplastic origin USE is a valuable method in determining the sequence of manipulations in the diagnostic program, but it cannot be a means of making the final diagnosis.

Acute Disease↗

PubMed1990

[Lipid peroxidation and disorders of erythrocyte properties in patients with mechanical jaundice].

Changes in the activity of lipid peroxidation (LPO) and the attendant disorders of the properties of the red cells were studied from the results of examination of 32 patients with obstructive jaundice. The data obtained showed that the LPO processes were markedly activated, which led to changes of the red cell membrane properties--reduction of their electric charge, osmotic resistance, and deformity. All this led to metabolic shifts promoting cell destruction. The efficacy of hemosorption was due to sorption of the LPO toxic products rather than to the removal of bilirubin.

Adult↗

PubMed1989