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Biomedical subjects

M Ia Ruda

Publications and source records attributed to M Ia Ruda.

At least 55 records · Page 3Linked to original sources
PubMed1990

[Possibilities of the use of 99mTc pyrophospate myocardial scintigraphy in the early period of myocardial infarct in the evaluation of the effectiveness of thrombolytic therapy].

In early (mean time, 6.9 +/- 0.2 hours following the onset of an anginal episode), 99mTc pyrophosphate myocardial scintigraphy was performed in 28 patients who received thrombolytic therapy under angiographic monitoring. The sensitivity and specificity of an early administration of pyrophosphate into the myocardium as a noninvasive marker of successful coronary reperfusion was 95.7% and 100%, respectively.

Adult↗
PubMed1990

[Effects of restoration of coronary circulation on the function of the left ventricle in patients with acute myocardial infarction (a follow-up after 1 year)].

Values of overall and local left ventricular function were studied in 89 patients in the acute period and 1 year following myocardial infarction. Three patient groups were identified: (1) 26 patients with coronary artery patency recorded by the first coronary angiography; (2) 20 with coronary blood flow recovery made by thrombolytic therapy; and (3) 40 with coronary occlusion. There was a significant improvement of left ventricular function in the patients from Group 1 during their hospital treatment and 1 year after.

Adult↗
PubMed1990

[Results of repeated coronary angiography in patients with unstable angina pectoris in a long-term follow-up].

A total of 27 patients with unstable angina pectoris were examined in the acute period of the disease and 3.4 years later (from 30 to 51 months). A group of patients with a favorable outcome of unstable angina comprised 13 patients who had displayed no recurrences of disease exacerbation, but that of patients with an unfavorable outcome of unstable angina consisted of 14 patients who had had recurrences of symptoms of progressive angina until myocardial infarction (in 6 patients). Coronary angiography made during the first hospitalization showed that 40% of the patients exhibited a "complicated lesion" of the symptom-related artery, which further transformed to an uncomplicated one (Type I stenosis according to the classification by J. Ambrose et al.), the remaining developed coronary occlusion. Comparison of the specific features of a course of the disease and coronary angiographic findings revealed no relationship between the degree of symptom-related artery stenosis and the long-term outcome of unstable angina.

Adult↗
PubMed1990

[Modern methods for the instrumental diagnosis of intracavitary thrombosis of the left ventricle in myocardial infarct].

To study the sensitivity and specificity of two-dimensional echocardiography in the diagnosis of left ventricle thrombosis which often attends myocardial infarction and to define diagnostic potentialities of the new research methods (digital subtraction ventriculography and MR tomography), 449 patients with acute transmural myocardial infarction were examined. Based on the comparison of the echocardiographic readings and morbid anatomy data it has been shown that the sensitivity of two-dimensional echocardiography in revealing left ventricle thrombosis amounts to 89%, specificity to 88%. Digital subtraction ventriculography has a lower (77%) sensitivity, with the specificity being satisfactory enough (88%). Meanwhile MR tomography enables a highly precise diagnosis of left ventricle thrombosis and can be used as a supplementary diagnostic method in questionable cases and in thrombi small in size or in unsatisfactory ultrasonic visualization of the heart structures.

Echocardiography↗
PubMed1990

[What we found one year after conducting thrombolytic therapy with myocardial infarct patients].

As many as 135 patients with myocardial infarction were under observation for a year. All the patients had received thrombolytic therapy 3.9 +/- 0.2 h on the average after the onset of an anginal attack. The patients with the recovered coronary blood flow (group I) manifested a more frequent occurrence of angina pectoris (38%) and repeated myocardial infarctions (8%) as compared to those with persisting occlusion of the coronary artery (group 2)--12 and 1.6% respectively. According to the coronary angiography, group I patients with angina pectoris showed high values of the degree of residual stenosis; the development of reocclusion characterized by the asymptomatic course at the long-term period. Group I patients were noted to have a decrease in the hospital lethality and lethality during the first year.

Adult↗
PubMed1990

[Immediate and late prognosis in patients with unstable angina under medical treatment].

The study was undertaken to examine 221 patients with unstable angina (UA) in the acute period and repeatedly on average of 5.3 years later. Myocardial infarction and sudden coronary death were regarded as unfavorable outcomes of UA. Out of all the patients included into the study, 33 (15%) developed myocardial infarction on days 2-28 of hospital stay, which resulted in death in 7 patients; 6 more patients died suddenly. The hospital mortality rate was 5.8%. Of 175 patients discharged from the unit, 31 developed myocardial infarction in the late period, 1 case ended with a fatal outcome, sudden coronary death was observed in 32 cases. The mortality rates by years were the following: 10.2% within the first year, 17.4% for 3 years, and 28.2% for 5 years. The choice of a complex of initial signs mostly significant for defining the risk for complications with the use of Cox's model of proportional risks indicated that the outcome of UA was affected by the following significant factors: 1) ST segment depression in the leads V4-V6; 2) duration of aggravated condition; 3) duration of coronary heart disease; 4) the number of resting anginal episodes; 5) a patient's fitness on his admission to hospital; 6) a history of arterial hypertension; 7) negative T waves in the leads V4-V5.

Adult↗
PubMed1990

[Blood lipophages in patients with ischemic heart disease].

Ninety three individuals were examined and divided into 3 groups: (1) patients with coronary heart disease in the presence of angiographically documented coronary atherosclerosis; (2) those with non-specific aortoarteritis; and (3) subjects without signs of cardiovascular disease. Blood levels of lipid-saturated mononuclear cells were measured by flow cytofluorimetry. The patients (42 (90%) patients of 46) of the first group were found to have higher blood lipophages than those of the other groups, no correlation being established between the plasma content of total cholesterol, high density lipoprotein cholesterol and triglycerides.

Adult↗
PubMed1990

[Effects of beta adrenergic blocking agents and calcium antagonists on atherogenic properties of blood serum of patients with ischemic heart disease].

The beta-adrenoblockers anapriline and visken and the calcium antagonist corinfar were studied for effects on the atherogenic properties of the sera from patients with coronary heart disease who took the drugs. The study was performed by using cultured atherosclerotically altered human aortic smooth muscle cells. A single dose of anapriline, 80 mg, and that of visken, 20 mg, were found to give rise to or to enhance atherogenic properties of the patients' sera, while that of corinfar, 20 mg, yielded their antiatherosclerotic properties.

Adult↗
PubMed1990

[Value of 24-hour ECG Holter monitoring in the evaluation of painless episodes of ST segment depression in patients with ischemic heart disease].

The paper presents the results of examination of 149 patients with ischemic heart disease. All the patients underwent 24-hour Holter monitoring; selective coronary angiography according to M. Judkins was performed in 142 patients, 29 patients were subjected to a bicycle ergometric test adopted in the All-Union Cardiology Research Center, USSR Academy of Medical Sciences. In the patients with ischemic heart disease, features and rates for detecting the painless episodes of ST-segment depression from the data of 24-hour Holter monitoring. Painless episodes of ST-segment depression were revealed in 82% patients with sclerosing atherosclerosis of the coronary bed. These were most frequently found in patients with three diseased vessels in the coronary bed or impaired left coronary trunk. Painful episodes of ST-segment depression were more pronounced and prolonged in the majority of patients.

Angina Pectoris↗
PubMed1989

[Dynamics of blood lipoprotein and apolipoprotein spectra in patients with unstable angina syndrome during a 1-year follow-up].

During one-year follow-up, plasma lipoprotein (Lp), and apolipoprotein (apo) spectra were studied in 119 patients with unstable angina (UA). Total lipids, cholesterol, various Lps, and apolipoproteins (apo B and apo AI) were examined in the plasma. The patients with UA showed more profound shifts in the spectrum of plasma apolipoproteins. In the patients, high density lipoprotein cholesterol levels below 37-38 mg/dl and an apo B/apo AI ratio over 1.7-1.9 were found to be a sign of high risk for myocardial infarction. It was ascertained that a relationship existed between the clinical course of the disease and changes in the plasma Lp and apolipoprotein spectra in the patients who failed to develop myocardial infarction over the one-year follow-up. During a year, increased "atherogenic" changes in the spectrum of Lp, apo were revealed in patients with a more severe clinical course of the disease as compared to an "instability" period; when the disease proceeded favourably, a "positive" time-course of these parameters was observed.

Adult↗
PubMed1987

[Dynamics of ventricular arrhythmia in the acute period of myocardial infarction].

Patients with acute myocardial infarction exhibited during the first three days of the disease pronounced intra- and interindividual variability in the amount of ventricular ectopic complexes and significant differences in the dynamics of the number of single premature beats and complexes in the so-called "complex" arrhythmias--paired premature beats, periods of ventricular tachycardia and accelerated idioventricular rhythm. The regularities revealed may be used for the additional evaluation of antiarrhythmic drugs efficacy in myocardial infarction.

Aged↗
PubMed1987

[Initial experience with using phosphocreatine in patients in the early (up to 6 hours) period of myocardial infarction].

A randomized study of 60 patients with myocardial infarction (MI) admitted to hospital in the first 6 hours of the disease was performed in order to study the effect of phosphocreatine (PC) on the course of MI. 30 patients were treated with PC; control group consisted also of 30 patients. PC infusion in the early period of MI resulted in the decreased frequency of ventricular arrhythmias (including paroxysms of ventricular tachycardia) and lowered likelihood of cardiac failure development. No reliable influence of PC on the central hemodynamics, heart rate, heart conduction and myocardial necrosis size was determined.

Adult↗
PubMed1986

[Intravenous administration of nitroglycerin to patients with unstable stenocardia].

Thirty-two patients with unstable angina were given i.v. infusions of nitroglycerin (from 2 h to 9 days, an average of 62 h) under the control of the level of arterial pressure. Indications for i.v. administration of nitroglycerin were frequent attacks of angina of effort and at rest in combination with prolonged angina attacks which persisted in spite of treatment with nitrates of prolonged action, calcium antagonists and beta-blocking agents. A moderate decrease in arterial pressure without significant change in heart rate was noted against a background of nitroglycerin infusions. The best antianginal effect was achieved in patients with frequent angina attacks, and on the whole a stable state using i.v. nitroglycerin infusions was achieved in 2/3 of the patients. A low antianginal efficacy of i.v. infusion of nitroglycerin in patients with unstable angina was an unfavorable prognostic sign: in this group myocardial infarction developed approximately in half of the patients during their stay in hospital.

Adult↗