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Biomedical subjects

M Ia Ruda

Publications and source records attributed to M Ia Ruda.

At least 73 records · Page 4Linked to original sources
PubMed1985

[Dynamics of blood fibronectin level in myocardial infarction].

The fibronectin level in the blood of patients with myocardial infarction was measured at varying times from the onset of an angina pectoris attack in order to elucidate the diagnostic importance of blood fibronectin. At the same time these patients were examined over time for the blood content of myoglobin, MB creatine kinase protein and C-reactive protein playing a well-known role in the diagnosis. The blood concentrations of these substances reached the maximal values at different times of myocardial infarction. The mean concentrations of fibronectin in the blood of patients with myocardial infarction ranged within normal starting from the first till the 28th day since the onset of an angina pectoris attack. Moreover, the mean blood fibronectin level in myocardial infarction patients did not differ within the first-third days since the disease onset from that in patients with a clinical picture of unstable angina pectoris which was not accompanied by the development of myocardial infarction. Based on the data obtained it is concluded that measurement of blood fibronectin level does not play any diagnostic role in myocardial infarction. On the other hand, progressive increase in blood fibronectin level throughout 4 weeks starting from the 3d day of the disease and a significantly higher fibronectin content on the 28th day as compared with that on the 3d day is likely to mirror the activity of repair processes occurring in the myocardium.

C-Reactive Protein↗
PubMed1984

[Effect of isoptin (verapamil) on the indicators of central hemodynamics in patients with acute myocardial infarction].

Verapamil was administered to 35 patients with acute myocardial infarction during the first 12 h of the disease. Parameters of the central hemodynamics were studied by invasive methods: the end diastolic pressure in the left artery was measured after its sounding with Swan-Ganz catheter, the cardiac output was measured by the method of thermodilution using a special computer. It has been established that in patients with clinically uncomplicated acute myocardial infarction, isoptin used in doses higher than those usually employed in the treatment of arrhythmia and angina in coronary heart disease patients caused no serious changes in the central hemodynamics which could have limited its administration in the above dosage. The negative inotropic action of verapamil in these patients is insignificant and seems to be compensated by its potential vasculodilating properties.

Adult↗
PubMed1984

[Changes in enzyme activity in extra-infarct portions of the myocardium after administration of nitroglycerin].

Nitroglycerin administration to rabbits with experimental myocardial infarction induced in extrainfarctional areas of the cardiac muscle the activity of dehydrogenases of succinate, lactate, glucoso-6- phospate , glutamate, beta-hydroxybutyrate and nonspecific esterase. This suggests the intensification of the redox reactions in Crebs ' cycle, the increased utilization of fatty acids by cardiomyocytes to meet energy requirements, a decreased degree of acidosis in these myocardial sites and the intensification of glucose direct oxidation and nitrogen metabolism normalization. The beneficial influence of nitroglycerin on many metabolic processes in the intact myocardial areas during the local impairment of the coronary blood flow may account for the improvement of left ventricular contractility observed in myocardial infarction following the administration of this drug.

Animals↗
PubMed1984

[Clinical evaluation of dynamic scintigraphy of the myocardium with Tl-201 in patients with acute myocardial infarction].

Thirty-six patients hospitalized because of suspicion for acute myocardial infarction (AMI) were examined within the first 24 hours after symptoms of the disease manifested themselves and during the follow-up on days 5-6 and 28-30. Myocardial perfusion was examined using the technique of perfusion myocardial scintigraphy with 201Tl. In cases of an uncomplicated course of AMI, the scintigrams showed a reduction in the area of perfusion defects (a positive time-course) whereas when the disease progressed the scintigrams reflected a negative time-course expressed in an expansion of the area of perfusion defects. When the scintigrams taken within the first 24 hours of AMI and over the follow-up period showed extensive perfusion defects, the time-course of the disease was severe with a large number of complications, the prognosis being usually poor. The pattern of the thallium scintigraphic picture at various periods of AMI was demonstrated to be heterogeneous. The degree of the perfusion defect, the time-course of its changes during the follow-up can be predictive in relation to the development of circulation insufficiency and mortality.

Adult↗
PubMed1984

[Use of lidocaine peridural anesthesia in patients in the acute phase of a myocardial infarct].

Peridural anesthesia was performed in 18 patients with acute myocardial infarction aimed at controlling the pain syndrome. In 12 of these patients, the authors studied for 24 hours the central hemodynamics by exploring the pulmonary artery with a Swan-Ganz balloon catheter and thermodilution. The central hemodynamics was also studied in the control group of patients in whom the analgesic methods conventially used in acute myocardial infarction were employed. During the first hour of peridural anesthesia in patients with myocardial infarction, the authors revealed a significant decrease in the blood pressure, heart rate, cardiac output, and in the end diastolic pressure in the pulmonary artery as compared with the initial values and the parameters in the control group. No significant changes in the cardiac stroke volume, stroke performance, the index of the cardiac stroke performance, and the total peripheral resistance were detected in these patients. The use of peridural anesthesia proved highly effective for controlling pain in acute myocardial infarction.

Acute Disease↗
PubMed1984

[Diagnosis of thrombosis of the left ventricle in patients with acute myocardial infarction using 2-dimensional echocardiography].

The authors demonstrate the possibilities of two-dimensional echocardiography in the diagnosis of left ventricular thrombosis (LVT) with special reference to patients with acute myocardial infarction (AMI). Provide the data of echocardiographic examination of 34 patients with transmural AMI. LVT was identified in 8 patients with anterior AMI. The authors show the relationship between the development of LVT and the site and extent of lesion, and the degree of left ventricular contractility disorders. Outline the prospects of further studies into LVT in patients with AMI.

Adult↗
PubMed1982

[Effect of nitroglycerin on various enzyme activity in the peri-infarction area of the myocardium].

A histochemical study of the activity of some enzymes in the peri-infarction area of rabbit myocardium in response to nitroglycerin showed the latter to increase the activity of oxydative-reductive enzymes in heart tissue, reduce acidosis, intensify the pentosephosphate cycle and contribute to a more intensive resorption of necrotized muscular fibres. These effects are conducive to better cardiomyocytes survival in the peri-infarction area and a more intensive organization of the infarction, this reducing the size of the affected area.

Animals↗
PubMed1981

[Effect of long-term sublingual administration of nitroglycerin on the indicators of hemodynamics and changes of total ST segment shift in 35 precordial leads in acute myocardial infarct].

Limitation of the final dimensions of a myocardial infarct is a new trend in the treatment of this disease. Nitroglycerin is considered to be one of the most active agents in this respect. The effect of 4-hour sublingual medication with nitroglycerin on changes in the values of precordial cartogram and central hemodynamics was studied. A significantly more rapid dynamics of the overall ST segment displacement under the effect of treatment and favourable shifts in the hemodynamic values were demonstrated. The dynamics of the latter under the effect of nitroglycerin medication varied in its trend and depended on the initial parameters.

Adult↗
PubMed1981

[Effect of intravenous administration of nitroglycerin on the lesion size in acute myocardial infarct].

A controlled study conducted in 60 patients (treated group 33 patients, control group 27 patients) showed that intravenous infusion of nitroglycerin results in 4 hours in a significantly positive dynamics of the parameters of precardial cartogram in 35 leads. Study of serial activity of CPK and MB fraction of CPK showed that a significant difference in the size of the affection is revealed only by the results of CPK examination. It was also established that a diminution in the size of the affection is possible both in increased end diastolic pressure in the pulmonary artery and in normal initial value, which does not allow the mechanism of the protective nitroglycerin effect to be explained only by the hemodynamic action of vasodilation.

Drug Evaluation↗