PubMed Health⌕ Search

Biomedical subjects

M Islam

Publications and source records attributed to M Islam.

84 records · Page 5Linked to original sources
PubMed1975

Urinary incontinence: a challenge and a solution. III. Plication of muscles of deep perineal pouch.

A new operation, very simple to perform under local anesthesia, is described for urinary incontinence caused by operations on the prostate gland or the bladder neck; satisfactory results have been obtained, with no complications to date. The surgical procedure consists essentially of plication of the external urethral sphincter and other muscles in the deep perineal pouch thereby increasing their tone, which appears to assist the smooth muscle sphincter for urinary continence.

Anesthesia, Local↗
PubMed1973

Krabbe's disease: globoid cell leukodystrophy.

The clinical features of regression in mental and motor development of a 7-month-old child are reported, together with the demonstration of a profound deficiency of galactosylceramide beta-D-galactosidase in a liver biopsy. The diagnosis of Krabbe's disease or globoid cell leukodystrophy (GLD) is therefore unequivocally established. The clinical features and morbid anatomical findings permitting the diagnosis of GLD in two of the child's sibs are summarized. This is the first report from Newfoundland of this inborn error of sphingolipid metabolism.

Diffuse Cerebral Sclerosis of Schilder↗
PubMed1972

Purification and comparative properties of isoenzymes of nicotinamide-adenine dinucleotide phosphate-isocitrate dehydrogenase from rat heart and liver.

1. Rat liver and heart major isoenzymes of NADP-isocitrate dehydrogenase have each been purified about 100-fold by a combination of ammonium sulphate fractionation and chromatography on ion-exchange cellulose and their properties compared. 2. The properties were similar in respect of pH, inhibition by Hg(2+) and Michaelis constants for isocitrate and NADP. 3. Some of the properties of the isoenzymes were different. 4. The heart isoenzyme was activated about 210% by 0.8m-ammonium sulphate whereas the liver isoenzyme was unaffected. The heart isoenzyme showed greater sensitivity to inactivation by heat (30 degrees C for 30min), whereas the liver isoenzyme was more sensitive to inactivation by p-chloromercuribenzoate and by Cu(2+). 5. The Michaelis constants with 3-acetylpyridine-adenine dinucleotide phosphate showed a twofold difference between liver and heart isoenzyme. 6. The differential sensitivity to heat and its mainly non-cytoplasmic location may be an explanation of the failure of plasma isocitrate dehydrogenase activity to increase after a myocardial infarction.

Animals↗
PubMedDate not supplied

Depletion of hepatic glycogen in the hypoglycaemia of fatal childhood diarrhoeal illnesses.

To determine whether depletion of liver glycogen or accumulation of liver fat (steatosis) was associated with the development of hypoglycaemia in children with fatal diarrhoeal illnesses, a case-control study was carried out comparing 17 children who had blood sugars less than or equal to 30 mg/dl with 17 age matched control children who had blood sugars greater than or equal to 59 mg/dl. The most common causes of diarrhoea in the hypoglycaemic children were Shigella sp. and Vibrio cholerae. The mean duration of diarrhoea before admission for the hypoglycaemic children, 7.8 d, was shorter than the 20.7 d for the controls (P less than 0.01). Most children in both groups showed signs of malnutrition, metabolic acidosis, and pneumonia. Liver specimens were obtained at post-mortem examination and stained with haematoxylin and eosin for general assessment and with periodic acid-Schiff stain for glycogen. Glycogen depletion was detected in 9 hypoglycaemic children and in only 3 control children (P less than 0.05). Hepatic steatosis, on the other hand, occurred with equal frequency in both groups but was associated with severe malnutrition in the hypoglycaemic patients (P less than 0.05). This result suggested that hypoglycaemia develops during acute diarrhoeal illnesses because gluconeogenesis fails to maintain the blood sugar concentration after depletion of liver glycogen. Frequent feeding of children with diarrhoea might help to prevent this complication.

Acidosis↗
PubMedDate not supplied

Fluorescent chelates for monitoring metal binding with macromolecules.

Metals and radionuclides are usually coupled with proteins together with suitable ligands for therapeutic, tumor-imaging, pharmaceuticals, and biocompatibility applications. Several ligands that can strongly coordinate a given nuclide in a specific valency are already known. However, the demand for bifunctionality has limited the applications of these ligands. We hereby report the molecular design of a receptor system based on the linkage of protein to monoazo ligands. By use of basic coordination chemistry, 4-(3-quinolinoazo)hydroxybenzoic acid (QABA) and derivatives were successfully conjugated to ovalbumin, bovine serum albumin, and alkaline phosphatase at a site that was distinct from the metal binding site. The presence of carboxylic acid linkage in the QABA served as a convenient bridge for protein conjugation and may allow the generic application of these ligands for bioconjugate synthesis while ensuring a high in vivo stability. The ligand-protein conjugates were characterized using UV-vis spectroscopy, Fourier transform infrared spectroscopy, thin layer chromatography, NMR, and surface-enhanced laser desorption ionization time-of-flight mass spectrometry. The conjugate was tested for the ability to recognize nonradioactive Ga(3+) at a physiological pH, and a binding constant of 1 x 10(20) was recorded. Also, the in vitro testing results indicated that the fluorescent conjugates exhibited significant selectivity for gallium compared to Pb(2+), Hg(2+), Zn(2+), Cu(2+), Fe(3+), and Co(2+) while no responses were obtained for alkaline and alkaline earth metals. These attributes could allow these conjugates to be used as a model for imaging sensors and for metal detection.

Calibration↗
PubMedDate not supplied

Acute lower respiratory tract infections in hospitalized patients with diarrhea in Dhaka, Bangladesh.

This study focused on 401 children less than 5 years old who were hospitalized with acute lower respiratory tract infection (ALRI) and diarrhea in Dhaka, Bangladesh, and who were investigated for the presence of both bacterial and viral respiratory tract pathogens as well as for selected diarrheal pathogens. The most common manifestations of ALRI were pneumonia (374 cases), bronchiolitis (12 cases), and tracheobronchitis (11 cases). The majority (77%) of the illnesses were in children less than 2 years of age, and 88% of the children were malnourished. A respiratory tract pathogen was identified in 30% of the patients, and a diarrheal pathogen was identified in 34%. The overall case-fatality rate in children with ALRI and diarrhea was 8%. The case-fatality rate was 14% in children with bacterial pneumonia and diarrhea, 3% in those with viral pneumonia and diarrhea, and 14% in malnourished children with shigellosis and ALRI. The most common respiratory tract pathogens were respiratory syncytial virus, Streptococcus pneumoniae, influenza viruses, and Haemophilus influenzae type b.

Acute Disease↗
PubMedDate not supplied

Prevalence of enamel hypoplasia and isolated opacities in the primary dentition.

PURPOSE: Enamel hypoplasia is of interest to both the clinician and the basic scientist because it may indicate an increased risk for caries and can contribute to the understanding of enamel development. The purpose of this paper is to report the prevalence of enamel hypoplasia and isolated enamel opacities in a cohort of healthy, well-nourished children in Iowa. METHODS: The study sample consisted of 698 children examined at 4-5 years of age. Individual tooth surfaces were scored for the presence of enamel hypoplasia (EH) and isolated enamel opacities. Prevalence of EH and isolated opacities were determined by tooth type and by gender. RESULTS: Six percent of the children examined had at least one tooth with EH; 27% had at least one tooth with isolated enamel opacities. There was no difference in the prevalence of EH between boys and girls, but significantly more boys than girls had enamel opacities. CONCLUSIONS: The prevalence of enamel defects in this study group is comparable to that seen in other studies of normally developed children except that in this study, the primary tooth types most commonly affected with enamel hypoplasia or isolated opacities were mandibular second molars and maxillary second molars, respectively.

Adult↗
PubMedDate not supplied

All about STDs.

Explore the source record for details and available documents.

Acquired Immunodeficiency Syndrome↗