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Biomedical subjects

M Jarmulowicz

Publications and source records attributed to M Jarmulowicz.

At least 19 recordsLinked to original sources

Pure small cell carcinoma of the prostate.

Pure small cell carcinoma of the prostate is a rare anaplastic tumour. This report presents the clinicopathological findings of two patients presenting with this disease. Immunohistochemistry was positive for protein gene product 9.5, neurone specific enolase and calcitonin. Staining was negative for prostate specific antigen and prostate acid phosphatase. androgen ablation has no place in the management of this lesion and patients with this disease should be managed as if they have a neuroendocrine tumour.

Aged↗

Massive colonic haemorrhage from a solitary caecal varix.

A 51 year old lady with chronic active hepatitis presented with massive lower gastrointestinal tract bleeding. Angiography demonstrated a solitary varix in the caecum which was found at laparotomy to be entering the bowel wall at the site of adhesion from a previous appendicectomy. The portal pressure was found to be raised. A right hemicolectomy stopped the blood loss, but she subsequently died of liver failure. Solitary colonic varices associated with adhesions are extremely rare and their optimal management has not been established.

Appendectomy↗

Hepatocellular carcinoma arising in non-cirrhotic haemochromatosis.

Hepatocellular carcinoma arising in a patient with genetic haemachromatosis, without cirrhosis, has only been described once previously. We present a patient with a 15 year history of genetic haemachromatosis who underwent resection of a hepatocellular carcinoma in a liver with normal architecture.

Aged↗

Fibroblastic rheumatism.

The first British case of fibroblastic rheumatism is reported. Treatment with apha-interferon in combination with a reducing course of steroids resulted in some regression of the cutaneous nodules, and initial improvement in the skin fibrosis and digital contractures.

Adult↗

The superior mediastinal approach to hepatic malignancy.

A 26-year-old man presented with superior vena caval obstruction. He underwent excision of a malignant teratoma which contained benign hepatic tissue. Three years later he represented with a recurrence and underwent a second resection. Histology of the resected specimen demonstrated hepatocellular carcinoma arising in the hepatic component of the recurrent malignant teratoma intermediate.

Adult↗

Embryo biopsy.

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Biopsy↗