Biomedical subjects

M Jonson

Publications and source records attributed to M Jonson.

At least 19 recordsLinked to original sources

PubMed2004

Electronic transduction in model enzyme sensors assisted by a photoisomerizable azo-polymer.

We develop a stochastic model of electronic transduction by means of a rod-like azo-polymer (single peptide molecule doped with a given amount of azo-benzene structural units) in polymer-redox enzyme biosensor. We propose a configuration where the azo-polymer is anchored next to the enzyme reaction center and functions as a light-driven micromechanical actuator shuttling electrons toward the electrode. We show that the output catalytic current is exponentially sensitive to variations in geometrical size of the polymer (a 'switch off' effect) and suggest a scheme where the switching effect is triggered by polymer photoisomerization, resulting in its overall length change.

Biosensing Techniques↗

PubMed2004

Quantum shuttle phenomena in a nanoelectromechanical single-electron transistor.

An analytical analysis of quantum shuttle phenomena in a nanoelectromechanical single-electron transistor has been performed in the realistic case, when the electron tunneling length is much greater than the amplitude of the zero point oscillations of the central island. It is shown that when the dissipation is below a certain threshold value, the vibrational ground state of the central island is unstable. The steady state into which this instability develops is studied. It is found that if the electric field E between the leads is much greater than a characteristic value E(q), the quasiclassical shuttle picture is recovered, while if E< 0) shuttle vibrations.

Journal Article↗

PubMed2003

Electrical manipulation of nanomagnets.

We demonstrate that it is possible to manipulate the magnetic coupling between two nanomagnets by means of an ac electric field. In the scheme suggested, the magnetic coupling is mediated by a magnetic particle that is in contact with both nanomagnets via tunnel barriers. The time-dependent electric field is applied so that the height of first one barrier then the other is suppressed in an alternating fashion. We show that the result is a pumping of magnetization from one nanomagnet to the other through the mediating particle. The dynamics of the magnetization of the mediating particle allows the coupling to be switched between being ferromagnetic and being antiferromagnetic.

Journal Article↗

PubMed2002

Mechanical Cooper pair transportation as a source of long-distance superconducting phase coherence.

Transportation of Cooper pairs by a movable single Cooper-pair box placed between two remote superconductors is shown to establish coherent coupling between them. This coupling is due to entanglement of the movable box with the leads and is manifested in the suppression of quantum fluctuations of the relative phase of the order parameters of the leads. It can be probed by attaching a high resistance Josephson junction between the leads and measuring the current through this junction. The current is suppressed with increasing temperature.

Journal Article↗

PubMed2002

Missing mass effect in biosensor's QCM applications.

Nowadays, liquid applications of quartz crystal microbalance (QCM) opened a way for in situ studies of proteins, vesicles and cells adsorbed from the solution onto the QCM surface. The sensitivity of QCM to the viscoelasticity of the adsorbed biomaterial can be a reason of the experimentally observed deviation from a linear dependence of QCM resonant frequency on mass deposition (the so-called Sauerbrey relation) and can limit its application for biosensoring. Presented here rigorous theoretical analysis explains the deviation from ideal mass response of soft overlayers in the contact with liquid. The fundamental result of the theory is the analog of Sauerbrey relation for layered viscous/viscoelastic medium which can be exploited for the correct physical interpretation of QCM experimental data in biofluids, in particular for measurements of the 'true' surface mass of adsorbed biomolecular films. We predict a new physical effect 'missing mass' of the sample in liquid phase measurements and compare the results given by our theory with QCM measurements on supported membranes.

Adsorption↗

PubMed2001

Coherent transfer of Cooper pairs by a movable grain.

Superconducting circuits that incorporate Josephson junctions are of considerable experimental and theoretical interest, particularly in the context of quantum computing. A nanometre-sized superconducting grain (commonly referred to as a Cooper-pair box) connected to a reservoir by a Josephson junction is an important example of such a system. Although the grain contains a large number of electrons, it has been experimentally demonstrated that its states are given by a superposition of only two charge states (differing by 2e, where e is the electronic charge). Coupling between charge transfer and mechanical motion in nanometre-sized structures has also received considerable attention. Here we demonstrate theoretically that a movable Cooper-pair box oscillating periodically between two remote superconducting electrodes can serve as a mediator of Josephson coupling, leading to coherent transfer of Cooper pairs between the electrodes. Both the magnitude and the direction of the resulting Josephson current can be controlled by externally applied electrostatic fields.

Journal Article↗

PubMed1996