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Biomedical subjects

M K Heatley

Publications and source records attributed to M K Heatley.

At least 19 recordsLinked to original sources
PubMed2004

The association between clinical and pathological features in histologically identified chronic endometritis.

Although described originally as the sine qua non for endometriosis, plasma cells have been identified in the endometrium in a variety of other situations. This study of patients who did and did not have plasma cells in their endometrium was carried out to establish the association between the clinical presentations and a variety of pathological characteristics, particularly the presence of inflammatory cells including plasma cells in the endometrium. There was no evidence of an association between any of the presenting clinical conditions and the distribution, intensity or frequency of inflammation, including the component cell types (lymphocytes, eosinophils, plasma cells and neutrophil polymorphs) or stromal pigment, although there was an association between a history of abnormal bleeding and reactive changes in the surface endometrium (P = 0.0259). Thus this study confirms the findings of others that there is no specific clinical syndrome that is associated with the presence of plasma cells in the endometrium.

Adult↗
PubMed2003

Prognostic factors associated with vulval carcinoma in women aged above and below 65 years.

The pathological characteristics included in the current FIGO criteria as being of prognostic significance in vulval carcinoma were compared for 62 women aged over and under 65 years. Older women were more likely to have high-grade carcinoma, large tumours and tumours of higher stage than the younger women, although all the cases had infiltrated more than 1 mm into the dermis. Vulval carcinomas in older patients were more likely to have features that are usually associated with a poor clinical outcome than those encountered in the younger patients.

Age Factors↗
PubMed2002

How should we grade CIN?

How should we grade CIN? The grading of cervical intraepithelial neoplasia (CIN) is problematic. CIN represents a morphological continuum, but biopsies displaying this lesion are classified into two (e.g. Bethesda) or three grade categories, sometimes with poor reproducibility. There are also difficulties in reliably distinguishing low-grade CIN from its reactive simulants. Because of problems with inter- and intra-observer disagreement in the grading of CIN and the diagnosis of low-grade lesions, three expert contributions were commissioned to address the question 'how should we grade CIN?'.

Diagnosis, Differential↗
PubMed2002

Vimentin expression does not assist in predicting survival in ductal carcinoma of the breast.

AIMS: To establish the value of vimentin expression in predicting survival in patients with breast cancer. METHODS: Five-year follow-up data were obtained for 68 patients with ductal carcinoma (NOS) of the breast in whom vimentin expression had been studied in fresh frozen and formalin-fixed, paraffin-embedded tissue. The predictive value on survival of tumour size, growth fraction (as assessed using the Ki67 monoclonal antibody), oestrogen receptor status and Bloom and Richardson grade of the primary tumour, and the presence or absence of lymph node metastases in axillary samples, were also studied. RESULTS: Twenty-two patients died of their disease within 5 years of diagnosis. Vimentin expression either on frozen or paraffin sections did not provide a statistically significant prediction of survival. On univariate analysis tumour grade, size and the presence of lymph node metastases provided prognostic information. Only lymph node status was of independent prognostic importance on multivariate analysis. CONCLUSIONS: Whilst these results confirm the value of established prognostic factors, they do not support the use of vimentin expression in either fresh or fixed tissue for the prediction of survival in ductal carcinoma (NOS) of the breast.

Biomarkers, Tumor↗
PubMed2002

The presence of residual disease in the cervix of hysterectomy specimens from women in whom there has been a previous diagnosis of cervical carcinoma.

The frequency with which residual carcinoma was encountered in 33 simple hysterectomy and 52 radical hysterectomy specimens from women who had squamous cell carcinoma (67), adenocarcinoma (8), adenosquamous carcinoma (3) and other tumours (7) of the cervix was studied. Predicted pathological stage was IaI (32 cases), IaII (10), Ib (16) and IIa tumour (1). Patients whose original procedure consisted of a punch biopsy were predicted to have microinvasive disease (Stage IaI or IaII - 10 cases) and Ib lesions (11 cases). One patient's initial investigation consisted of a curettage and in four patients the stage could not be predicted. Margins of the original specimen were assessable in 54 cases (28 positive, 26 uninvolved). Residual tumour was identified in 32 cases and in eight was of higher stage than predicted. It was most likely to be identified if the original diagnosis was made on punch biopsy with no intervening treatment or in Stage IaII disease or greater. These results highlight the importance of thorough examination of the cervix attached to a hysterectomy specimen in patients with a diagnosis of invasive cervical carcinoma.

Biopsy↗
PubMed2002

Distribution of cervical glandular intraepithelial neoplasia: are hysterectomy specimens sampled appropriately?

AIMS: To establish the validity of assuming that by examining midline blocks from the anterior and posterior lips of the cervix, a previously unsuspected cervical intraepithelial glandular neoplasia (CIGN) lesion would be identified. METHODS: The distribution of CIGN in 30 cone biopsy specimens of cervix was examined. RESULTS: Nine low grade and 21 high grade cases were identified involving one or other lip in 29 patients and one or both lateral edges in 20. The distribution of CIGN was unifocal in 20 patients, involved two distinct foci in nine, and three distinct foci in one. Only three patients had a circumferential distribution. Midline disease, either CIGN or squamous cervical intraepithelial neoplasia (CIN), or both, was present in 27 patients. CONCLUSION: These findings suggest that examining the midline blocks from hysterectomy specimens will result in the identification of CIGN lesions in over 90% of patients, either because the CIGN lesion is present in the midline or because an associated squamous CIN lesion will be identified, which will result in the examination of the entire cervix, with the consequent identification of the CIGN lesion.

Biopsy↗
PubMed2001

Polyp of the fallopian tube.

The case of a 34-year-old woman who had a radical hysterectomy for stage 1 b squamous cell carcinoma of the cervix and in whom an epithelial polyp was identified in the left fallopian tube is presented. The case is unusual in that the polyp developed in the absence of any evidence of tubal damage as demonstrated by a history of endometriosis or tubal sterilisation.

Adult↗