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Biomedical subjects

M K Thompson

Publications and source records attributed to M K Thompson.

At least 19 recordsLinked to original sources
PubMed1989

Hypothesis: old people would benefit from a patient-held standardized primary health care record.

While many advances have been made in primary health care, for old people it has lagged behind other areas. The case is made for the adoption of a standard primary-care record for people aged over 70 years to be retained by the patient and attached behind the front door, where it would be available to ambulance crews, deputizing doctors and other community health workers. It would also be of value to the elderly patient when travelling or registering with a new doctor. Such a focus on information would facilitate communication between professional workers and increase productivity.

Aged↗
PubMed1986

Human immune response to iron-repressible outer membrane proteins of Neisseria meningitidis.

Neisseria meningitidis grown under iron-limiting conditions in vitro expresses additional iron-repressible outer membrane proteins (FeRPs). To see which FeRPs were expressed and immunogenic in human infection, we examined purified membranes from four meningococcal disease isolates with Western blotting of patient sera. Convalescent serum from each patient contained immunoglobulin G (IgG) and IgM antibodies against the homologous 70-kilodalton (kDa) FeRP and IgG antibody to the homologous 94-kDa FeRPs. Three other immunoreactive FeRPs were identified in two or more strains. Neither acute-phase sera nor pooled normal human sera contained appreciable levels of these antibodies. Antigenic cross-reactivity among FeRPs was suggested by the observation that the convalescent sera of two patients contained IgG antibodies reactive with the 70- and 94-kDa FeRPs and IgM antibodies reactive with the 70-kDa FeRPs from all four strains. Additionally, rabbit antiserum against the 70-kDa FeRP from one of these disease isolates contained IgG and IgM antibodies that reacted in Western blots with the 70-kDa FeRPs in all four strains. These results demonstrate that meningococcal FeRPs are expressed and immunogenic in vivo and that certain of these proteins are immunologically cross-reactive.

Antibodies, Bacterial↗