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Biomedical subjects

M Kent

Publications and source records attributed to M Kent.

34 records · Page 2Linked to original sources
PubMed1983

Thoracic neural crest tumors. A clinical review.

The experience of a regional children's hospital in the management of intrathoracic neural crest tumors over a period of 20 years is presented. Of 145 children with neuroblastoma between 1961 and 1980 inclusive, 115 had primary abdominal neuroblastoma (including pelvic) with a mortality of 86%; 30 patients had a thoracic neuroblastoma with a mortality of 16.5% (five patients). The more favorable outlook in this group should imply a more cautious approach to the initiation of treatment regimens which have their own morbidity and mortality.

Antineoplastic Agents↗
PubMed1983

The treatment of Wilms' tumor: results from Royal Children's Hospital, Melbourne, 1967-1977.

A retrospective review of the treatment of Wilms' tumor from 1967 to 1977 at the Royal Children's Hospital, Melbourne, was undertaken, allowing a minimum 2-yr followup. Fifty-four (77%) of the 70 patients in the study are alive, with 23/25 (92%) in Stage I, 12/16 (75%) in Stage II, 12/19 (63%) in Stage III, and 7/9 (78%) in Stage IV. Survival was significantly better in Stage I disease, and those patients less than 5-yr-old at presentation. Recurrence of disease was significantly lower after the introduction of multiple courses of chemotherapy in 1971. Sixteen deaths occurred during the period: three infants from drug toxicity, four patients with "unfavorable" sarcomatous histology, and four patients with recurrent local disease, where irradiation had been confined to the tumor bed after tumor spill with recurrence beyond the irradiated field.

Abnormalities, Multiple↗
PubMed1981

A rapid immunoadsorbent radioimmunoassay for anti-acetylcholine receptor antibody.

Antibody to the human nicotinic acetylcholine receptor has been demonstrated in the disorder myasthenia gravis and is the pathologic factor producing the characteristic symptoms of the disorder. A rapid, quantitative and sensitive radioimmunoassay using human acetylcholine receptor, affinity labeled with iodinated alpha-bungarotoxin, and utilizing the immunoadsorbent protein A-bearing Staphylococcal aureus is described. The assay has proven as effective and more efficient than double antibody immunoprecipitation assays in diagnostic screening, evaluation of various forms of therapy, determining kinetics of receptor and antibody interaction, and the production of antireceptor antibody by peripheral blood lymphocytes in culture.

Animals↗
PubMed1978

Pulmonary interstitial emphysema requiring lobectomy. Complications of assisted ventilation.

An infant with hyaline membrane disease treated with intermittent positive pressure ventilation developed pulmonary interstitial emphysema localised to one lobe after collapse of the affected lobe. The development of tension and further symptoms necessitated lobectomy, after which the infant became totally asymptomatic. Microscopy of the resected lobe showed the unusual feature of giant cells lining the air-containing cysts. The presence of these multinucleate cells suggested the cysts may have represented greatly dilated lymphatic channels resulting from rupture of gases into the pulmonary lymphatics.

Humans↗
PubMedDate not supplied

A paediatric emergency transport service: one year's experience.

A paediatric emergency transport service (PETS) has been developed in Melbourne to cater for the secondary evacuation of children beyond the neonatal period. A consultative and transport service is provided. Forty-six children were transported in the first year of operation and the details are now reported. It is believed that the service is fulfilling a hiatus in the delivery of emergency health care to regional centres and that it will reduce morbidity and mortality in this group of critically ill children.

Adolescent↗