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Biomedical subjects

M Khalid

Publications and source records attributed to M Khalid.

44 records · Page 3Linked to original sources
PubMed1987

Pulsatile GnRH administration stimulates the number of pituitary GnRH receptors in seasonally anoestrous ewes.

Twenty seasonally anoestrous ewes were pretreated with progesterone for 4 days and divided into four equal groups. Ewes in Group 1 received no GnRH treatment and were slaughtered immediately after progesterone removal. Ewes in Groups 2, 3 and 4 received i.v. injections of 250 ng GnRH every 2 h for 36 h starting at the time of progesterone removal. Ewes in Group 2 were slaughtered immediately after the 36 h GnRH pulsing, while ewes in Groups 3 and 4 were given a bolus injection of 125 micrograms GnRH at this time and were slaughtered 2 and 10 h after the bolus injection, respectively. Blood samples were collected every 30 min from ewes in Group 4 only, from 4 h before the start of GnRH treatment until 10 h after the bolus injection. Pulsing with GnRH resulted in episodic release of LH, and the bolus injection of GnRH was immediately followed by a preovulatory type LH surge in those ewes in which an endogenous surge had no already begun. The pituitary GnRH receptor numbers were significantly higher for the ewes in Group 2 than for any of the other treatment groups, while there was no significant difference in the receptor numbers between Groups 1, 3 and 4. The results suggest an up-regulation of GnRH receptors resulting from pulsatile GnRH therapy.

Anestrus↗
PubMed1987

N,N'-disubstituted L-isoglutamines as novel cancer chemotherapeutic agents.

Previous studies carried out in the authors' Institute revealed that one of the active metabolites of Antineoplaston A10 is phenylacetylisoglutamine. The objective of this study is screening of N,N'-disubstituted L-isoglutamine derivatives for selection of novel anticancer agents. A series of seven derivatives of L-isoglutamine was synthesized as potential chemotherapeutic agents. Antitumor activity studies were performed in tissue culture of breast carcinoma cells HBL-100. The acute toxicity study was carried out on a group of 60 HA/ICR Swiss mice. Among the compounds tested N alpha-(phenylacetylamino)-gamma-(4-amino-N-benzyl-piperidinyl)-L-g lutamyl amide was found to have the best anticancer activity and no significant acute toxicity. The LD50 was calculated by the moving average method and determined as 4.5 g/kg i.p. in mice. It is concluded that the important structural features for good antineoplastic activity are lipophilic groups on both amine and amide nitrogen of isoglutamine. The activity is also increased when the phenyl group present at the side chain is at least two carbon atoms away from the amide nitrogen.

Animals↗
PubMed1984

Post-traumatic subdural hygromas: observations concerning a surgical enigma.

Four per cent (38) of 881 head injured patients developed known subdural hygromas. Their times of onset and course were variable. However, only two large hygromas seemed clinically significant. Hygromas were more frequent when intracranial pressure monitors were placed, possibly due to opening of the arachnoid, particularly if intracranial pressure was low. But, of course, monitors were only inserted in more severely injured patients. The use of Richmond bolts to drain subdural hygromas in a controlled fashion while monitoring intracranial pressure is suggested.

Adult↗
PubMedDate not supplied

Anthropometric comparison between high- and low-altitude Saudi Arabians.

Measurements of weight, height, mid-upper arm circumference, mid-upper arm muscle circumference and skinfold thickness over the triceps region were made in 437 high-altitude residents (3150m above sea level) aged 16-60 years and 468 low-altitude residents (500 m above sea level) aged 16-60 years in southern Saudi Arabia. Compared with low-altitude residents, high-altitude residents were found to be significantly heavier and taller, but to have nearly similar mid-upper arm circumference, mid-upper arm muscle circumference and triceps skinfold thickness. Estimates of body fat have been made from the triceps skinfold measurements. No significant difference in the percentage of fat was detected between high- and low-altitude residents. When fat mass (kg) and fat mass index (fat mass (kg)/height in m2) were considered, similar trends were found between highland and lowland men only. Highland women showed significantly higher fat mass and fat mass index when compared with lowland women. These differences in physique between highland and lowland residents of southern Saudi Arabia may be attributed to the effect of environmental factors, possibly the hot climate and parasitic infections prevalent in lowland areas, in addition to the higher physical activity observed in lowland women.

Adolescent↗
PubMedDate not supplied

Sprinting on a running track: a rare cause of a Lisfranc dislocation.

We present a case report of a young man who sustained a serious foot injury while sprinting in a straight line. We discuss the management of these injuries and emphasise the importance of a high index of suspicion amongst orthopaedic, casualty and radiology trainees.

Adolescent↗