PubMed Health⌕ Search

Biomedical subjects

M Kirchgessner

Publications and source records attributed to M Kirchgessner.

At least 181 records · Page 10Linked to original sources
PubMed1983

[Effect of zinc deficiency on 3',5'-cyclic-AMP content and parameters of energy metabolism in the rat].

Loss of appetite, strongly reduced feed intake, and stop in weight gain are characteristic signs of alimentary zinc deficiency. The present paper investigates some parameters of the energy metabolism of Zn-deficient rats in order to obtain information on possible disturbances. The blood of Zn-deficient rats showed an increased activity of adenosine triphosphatase (ATPase) in comparison to ad-libitum- and pair-fed control animals. Therefore the concentration of adenosine triphosphate (ATP) was reduced and the concentration of adenosine diphosphate (ADP) increased in deficient animals. As a consequence, the ratio ATP/ADP was strongly reduced in Zn-deficient rats compared with both control groups. The concentration of adenosine monophosphate (AMP) was reduced in the blood of Zn-deficient rats. The levels of c-AMP in serum and urine were markedly increased in Zn-deficient rats in comparison with both control groups. Key enzymes of energetic utilization of carbohydrates such as fructose-1.6-biphosphatase and glucose-6-phosphate dehydrogenase were reduced in their activities in livers and kidneys of Zn-deficient animals. The results show that alimentary Zn deficiency impairs some parameters of the energy metabolism. The problems of reduced feed intake in Zn deficiency still remain unsolved.

Adenosine Diphosphate↗
PubMed1983

[Fe and Cu content in the liver, spleen, kidney and heart of growing rats with variable Fe and Cu supply].

In the course of a series of experiments on factorial Fe and Cu supply (0, 25, 250 and 625 micrograms Fe/g; 0, 10, 100 and 250 micrograms Cu/g), t effects on Fe and Cu contents of liver, spleen, kidney, and heart of growing rats were examined. Total contents as well as concentrations in these organs depended not only on the supply with the respective trace element but also on interactions between both trace elements. Iron doses of 250 and 625 micrograms/g resulted in an accumulation of Fe in the liver of Cu-deficient animals, but in reduced Fe contents in spleen, kidney, and heart. Following supplements of 250 micrograms Cu/g diet, liver Fe contents were significantly decreased under these conditions, whereas those of the other organs were not changed at all. On the other side, Cu doses of 100 micrograms/g and more caused a significant increase of liver Cu contents, if Fe supply was deficient or, partially, suboptimal. Total Cu of spleen and kidney and, as a rule, in heart, too, was significantly reduced in these animals. Variations in the retention behaviour of the different organs were observed concerning the interrelationships of the concentrations of Fe and Cu. A strongly inverse reaction of the two elements was observed in the liver of Cu-deficient as well as in sufficiently or excessively Cu-supplied rats. Both Fe and Cu concentrations in kidney and heart, however, increased when the Cu supplement was 10 micrograms/g or more. Cu deficiency caused reduced heart values, whereas in kidney a minimal increase was still observed. In spleen, no interrelationship in any direction was found.

Animals↗
PubMed1982

[Contents and distribution of Fe, Cu, Zn, Ni, and Mn in fetuses, amniotic fluid, placenta, and uterus of rats].

Fetuses, amniotic fluid, placenta, and uterus were taken from five gravid rats shortly prior to delivery, and the contents of Fe, Cu, Zn, Ni, and Mn were analyzed. Fe, Cu, Zn, and Mn exhibited a similar concentration in dry matter (DM) in all tested reproductive organs, whereby Fe-contents were five to ten times higher than Zn-contents and those five to ten times higher than Cu-contents, which amounted to 10-20 ppm. The Mn-contents range about a factor of ten below. Ni-concentration in DM of fetuses, placenta and uterus is below 1 ppm, whereas in contrast to this, Ni-concentration of 14 ppm in DM of amniotic fluid is 34 times higher than in fetuses and placenta. Uterus contained twice as much Ni as fetuses. Concerning the total content of the individual trace elements, Ni reacts also different as compared to Fe, Cu, Zn, and Mn. Its amniotic content exceeds the fetal content by 40%. Total excretion of Fe, Cu, Zn, Mn, and also DM is distributed differently as compared to Ni. Fetuses contain 60%-70% of these trace elements, placenta 15%-25%, uterus 6%-16%, and amniotic fluid only 1%-2%. Ni, however, is excreted mostly via amniotic fluid by about 35% of total excretion and only by about 25% via fetuses. These findings, concerning Ni, are discussed in detail.

Amniotic Fluid↗
PubMed1982

[Energetic utilization of Palatinit].

The retention of protein, fat and energy of Palatinit was measured in a trial with carcass analyses and compared with that of sucrose. Therefore 39 male rats weighing about 200 g were divided in three groups. In order to get basic values, 4 animals of each group were slaughtered. The other 3 X 9 animals were fed 56 days in one group the basal diet, in two other groups the same diet plus sucrose and Palatinit, respectively. The retention of dry matter, protein, fat and energy was calculated with carcass analyses. The results show that the supplement of Palatinit gave higher values of retention compared with the basal diet, but there was no change in the body composition. Compared with this, the supplement of sucrose brought not only higher values of retention, but also a changed carcass composition compared with the basal diet and the supplement of Palatinit, too; thereby the fat content was significantly higher, and the protein content was lower. The retention of energy was reduced by 33% with the supplement of Palatinit, compared with the isocaloric supplement of sucrose.

Animals↗
PubMed1982

[Fe-, Cu-, Zn-, Ni- and Mn-concentrations in sow's milk during a five-week lactation period].

In a trial with 18 sows of the German landrace in three groups the dietary copper supply was varied in gravidity and lactation. Iron, copper, zinc, nickel and manganese concentration of milk was measured on 11 different days during the five weeks' lactation period in response to alimentary copper supply. Copper supply did not influence iron, zinc, and manganese concentration even if it was deficient during gravidity and lactation. Mature sow's milk contained 1.2 micrograms Fe, 1.5 micrograms Cu, 6-8 micrograms Zn, 0.16-0.23 microgram Ni and 0.07-0.13 microgram Mn per g fresh milk. First colostrum contained higher copper and zinc concentrations and lower concentrations of nickel and manganese compared to mature milk. Fe concentration remained constant. This investigation reproduced and completed thereby previous results. It was concluded that in copper deficiency status the interactions of copper with iron, zinc, nickel and manganese may not be effective for the excretion pathway milk.

Animals↗
PubMed1982

[Optimal zinc requirement of lactating dairy cows based on various dose-response relationships].

Dose-response relationships were established by multiple regression analysis of data from a zinc depletion-repletion study conducted with five first-lactation cows in order to estimate optimum zinc requirement. Zinc supply in the various experimental periods ranged from 6 to 436 ppm in the dry matter of the semisynthetic diet. The response criteria were the zinc concentrations in serum and milk and the activity of the alkaline phosphatase in serum. They correlated best with the reciprocal of the dietary zinc concentrations. Serum zinc also showed a close negative relationship to daily milk production (9-24 kg) and milk zinc to stage of lactation (2-21 weeks post partum). The response of the activity of the alkaline phosphatase, which was sufficiently described by simple regression to the inverse of dietary zinc concentration, was limited to a distinctly lower zinc supply range than the response of the serum and milk zinc level. The optimum zinc requirement of the cows was estimated to have been met with about 35 ppm Zn in the ration on the basis that 90% of the maximum response of the serum and milk zinc concentration was reached at this supply level. In the practical feeding situation, dairy cows should, however, be allowed 50 mg zinc per kg dry matter intake according to current recommendations in order to make certain that the physiological capacity of milk to bind zinc is sufficiently fulfilled even at highest milk production.

Alkaline Phosphatase↗