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Biomedical subjects

M Kirschbaum

Publications and source records attributed to M Kirschbaum.

25 records · Page 2Linked to original sources
PubMed1984

[Light and electron microscopic studies on local reactions to implanted collagen hemostypticum--an experimental animal study].

A light and electron microscopic study was made on the resorption of native collagen fleece following its subcutaneous implantation or its application on a bleeding liver surface in 132 Wistar rats. Resorption of collagen began with the immigration of micro- and macrophages. Organisation of subcutaneous connective tissue was seen from day 5 p.o. to day 15 p.o. The excessive connective tissue was removed after 25 days and foreign body granulomas were eliminated after 50 to 100 days. Typical characteristics of application of the collagen fleece on bleeding liver surface are: Rapid hemostasis, mesothelisation of collagen towards the peritoneum after 1 day, resorption and organisation without adhesion after 10 days. The final heeling leads to a smooth thickening of the liver capsula with a few residual granulomas after 100 days.

Absorption↗
PubMed1983

The relationship of carotid sinus stimulation to exercise testing.

This review is an attempt to demonstrate the safety and usefulness of the simple maneuver of carotid sinus stimulation with selected subjects undergoing exercise tests. In a variety of circumstances the addition of CSP before or after treadmill walking can yield clinically relevant information relating to arrhythmias, conduction disturbances, symptoms, and pacemakers. Further applications and benefits of these combined procedures remain to be clarified and expanded for judicious application with attention to safeguards.

Angina Pectoris↗
PubMed1981

Ventricular function before and after mitral valve replacement.

To evaluate right ventricular function following mitral valve replacement, we studied 84 patients with isolated mitral valve disease with the use of first-pass radionuclide angiography before, 1 week after, and up to 1 year after operation. The right ventricular ejection fraction for the entire group improved from 29% +/- 11% to 43% +/- 10% (p less than 0.001) at 1 week. This increase was maintained at 3 months (41% +/- 10%) and up to year after operation (40% +/- 12%). The improvement was found not to be influenced by either the type of valvular lesion or the presence and/or level of pulmonary hypertension. When the patients were grouped according to the type of prosthetic valve placed at operation, the right ventricular ejection fraction increased in all patients within 1 week of operation, with sustained improvement at 3 months postoperatively. Thereafter, it began to decline in patients receiving a Carpentier bioprosthesis while being maintained in those patients who received disc valves. Further analysis revealed that those patients who receiving the larger Carpentier bioprostheses had a greater deterioration of right ventricular function than those receiving the smaller Carpentier valves. Left ventricular function in the entire group was normal preoperatively (62% +/- 16%) and was unchanged at 1 week (60% +/- 16%) and a 1 year (59% +/- 16%) after operation.

Adult↗
PubMedDate not supplied

[The uterine contraction stress test with oxytocin nasal spray in the diagnosis of hypoxemia].

Deceleration of the fetal heart rate are indications of fetal distress, which are commonly seen in connection with uterine contractions. The aim of the investigation was, whether nasal application of oxytocin (Syntocinon, Sandoz AG) is sufficient for the induction of contractions for an oxytocin-challenge-test. 232 oxytocin-challenge-tests in 85 risk patients between 29th-42nd week of gestation were analyzed in a retrospective and prospective way. The amounts of oxytocin nasal spray necessary for stimulating contractions were compared to the gestational age and maternal body weight (1 spray snuff = 4 IU Oxytocin). 20 pregnant women were given 8 IU oxytocin nasal spray after 10 minutes CTG-registration without any contractions. The incidence of induced contractions per ten minutes period were calculated. The amount of oxytocin nasal spray necessary for the stimulation of contractions decreased in relation to the increased gestational age and maternal body weight (oxytocin spray = 2.751-0.051 X (gestational age)-0.014 X (body weight), p less than 0.01). After a single application of 8 IU oxytocin nasal spray at least one contraction occurred in 13 out of 20 cases within the first 10 minutes. Between the 20th-30th minute the induced uterine contractions reached a maximum of 3 contractions per 10 minutes. No persisting contractions were observed. The application of 8 IU of oxytocin nasal spray is sufficient to induce in about 95% of the cases an oxytocin-challenge-test which gives information concerning the actual state of the fetus at risk.

Administration, Intranasal↗