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Biomedical subjects

M M Makhmudov

Publications and source records attributed to M M Makhmudov.

At least 19 recordsLinked to original sources

[Clinical features and diagnosis of congenital stenosis of the pulmonary artery and the right ventricular outflow tract].

AIM: To analyse clinical manifestations of congenital pulmonary artery stenosis (CPAS) and right ventricular outlet stenosis (RVOS), development of its diagnosis depending on anatomic variants of heart disease. MATERIAL AND METHODS: The data on 539 patients examined with conventional clinical and highly informative novel techniques were studied. RESULTS: The analysis of the CPAS and RVOS clinical picture depending on the anatomic variant of the heart disease has shown that clinical symptomatology was of the same type. The data of the tests have some specific features allowing identification of some forms of the heart disease. CONCLUSION: Diagnostic and prognostic significance of the findings was determined which gave rise to an optimal examination scheme with focus on wider use of highly informative techniques.

Adolescent↗

[Clinical picture and treatment of mediastinitis after correction of congenital heart diseases in open heart surgery].

Postoperative purulent mediastinitis was observed by the authors in 43 out of 1110 patients. Specific features of the clinical picture and course of this complication are described. The "closed" method of treatment was used in 20 patients. Five of them died from intoxication and arrosive bleeding. The "open" method of treatment of mediastinitis was used in 23 patients with no lethal outcomes.

Adolescent↗

[Surgical treatment of atrial septal defects and associated congenital heart diseases].

The results of radical correction of interatrial septum defects and heart diseases associated with it were analyzed after treatment of 502 patients at the age from 5 to 48 years. In most cases (58.4%) the patients were adults. The isolated defect of the interatrial septum was diagnosed in 377 patients. Correction of the defect was performed in 82 patients (16.3%) under mild hypothermia and 420 patients (83.6%) were operated upon under conditions of artificial circulation. General lethality was 7.7%.

Adolescent↗

[Surgical methods for correcting partial anomalous drainage of the pulmonary veins during artificial circulation].

The authors share their experiences with surgical treatment of 42 patients with different anatomical variants of the partial anomalous drainage of the pulmonary veins. Specific features of the surgical strategy are described depending on the level of confluence of the pulmonary veins, especially if the mouths of the abnormally falling pulmonary veins and the interatrial septum defect are far from each other. Good immediate and nearest results were obtained.

Adolescent↗

[The echocardiographic indices of patients with tetralogy of Fallot before and after the suturing of subclavian-pulmonary anastomoses].

Echocardiography was made in 69 patients with Fallot's tetrad before and 2 weeks-15 years after forming subclavian-pulmonary anastomosis (SPA). By the anastomosis function the patients were divided into 2 groups. 47 patients with satisfactory function of the anastomosis 3.2+ -1.06 years after the operation comprised group 1. 22 patients of group 2 had marked cyanotic syndrome due to thrombosis of the anastomosis 9.45 + -2.45 years after surgery. Echocardiography in Fallot's tetrad patients before and after SPA specified anatomic components of the defect, size of the left heart and results of the operation.

Adolescent↗

[Inter-arterial anastomosis in dextral position of the aortic arch in patients with tetralogy of Fallot].

The article discusses the results of formation of inter-arterial anastomoses in 58 (12.7%) patients with a severe form of Fallot's tetralogy in dextra-position of the arch of the aorta. The specific features of the course and diagnosis of dextra-position of the aortic arch in Fallot's tetralogy are analysed, and the significance of radiologic and echocardiographic examination in the choice of the position and type of interarterial anastomoses is determined. It is proved that Blalock-Taussig's anastomoses must be formed on the side opposite to the aortic arch, while shunting operations must be carried out on the side on which the arch of the aorta is located.

Abnormalities, Multiple↗

A new method of plastic surgery of the right ventricular outflow tract and pulmonary artery in experiment.

A new method of plastic surgery of the right ventricular outflow tract and the pulmonary artery without use of extracorporeal circulation (occlusion of main arteries) was tested in experiments carried out in 28 dogs. The method involves previous suture of a patch to the site selected for plastic surgery and, using an instrument designed by the authors, excision of the necessary part of the ventricular wall and pulmonary artery. The instrument consists of two handles, similar to those of pincers, and working on a pivot, with oval cavities on the inner sides of its elongated grasping jaws. The tip of lower jaw features a sloping edge to enable perforation of the outer wall of the heart. By pulling together the handles, connected with a spring, the jaws close excising the appropriate part of the heart. The depth of insertion of the jaws into the heart cavity's controlled by means of a graded scale on the outer side of the upper jaw. Using this technique it is possible to perform surgery even of extensive myocardial defects quickly, safely, with virtually no trauma and minimal loss of blood, and to remove large segments of the hypertrophic myocardium while retaining intracardiac circulation, without the need for extracorporeal circulation.

Animals↗

[Natural course of Ebstein's anomaly].

The natural course of Ebstein's anomaly of the tricuspid valve was studied in 42 conservative patients, their age ranging from 1 day to 38 years at 1st examination (12.3 +/- 1.5 years). Twenty-seven of 42 patients reported for a follow-up check after 3 to 21 years, while the remaining 15 had died as a natural outcome of the defect, heart failure and rhythm disorders being the most common causes of death. The 27 survivors had reached the age of 7-54 years (33.8 +/- 4.2 years), all of them showing a deterioration of the condition and progressing cardiomegaly.

Adolescent↗

[Ebstein's anomaly associated with pulmonary stenosis].

Although Ebstein's anomaly occurs mostly in isolation, in 2 to 5% of cases it is combined with pulmonary artery stenosis. This combination noticeably aggravates the natural course of the disease and complicates the diagnosis of the pathology. On the basis of five observations the authors present the specific differential-diagnostic signs which help to make the correct diagnosis. The key role in the identification of combined forms of Ebstein's anomaly is played by the catheterization of the cardiac chambers and by angiocardiography.

Abnormalities, Multiple↗