Biomedical subjects
Publications and source records attributed to M M Rasulov.
In patients with familial arterial hypertension and their relatives preclinical signs of myocardial hypertrophy were observed before the formation of stably increased blood pressure. We evaluated echocardiographic sings of left ventricular myocardial hypertrophy in normotensive relatives of patients with arterial hypertension.
Acute experiments on white laboratory rats were performed to study spike activity in neurons of the anterior hypothalamus in response to i.v. injections of different doses of oxytocin. The results showed that oxytocin evoked different types of rearrangement of neuron activity both in intact and in stressed animals. The dose-related effects of oxytocin affected the latent periods of neuron responses and the nature of rearrangements in spike activity. The greater the frequency of the baseline activity of the cells, the less marked was the response of the neurons to administration of oxytocin.
The dynamics of impulse activity of amygdaloid neurons in response to intravenous injection of oxytocin were examined in acute experiments on random-bred albino rats. Oxytocin modified activity of amygdaloid neurons in intact and stressed rats. The dose-dependent effects of oxytocin were manifested in changes in the latency of neuronal responses and in rearrangement of their spike activity. The oxytocin-induced neuronal responses were less pronounced in cells with high baseline activity.
We studied the dynamics of immune reactions to trekrezan in mouse pups after vaccination of adult mice during pregnancy and mouse pups at different terms after birth with Salmonella typhimurium 34-96. The preparation modulated activity of the immune system and stimulated antibody production in the pre- and postnatal period.
1-Ethoxysilatrane and 1-isopropoxygermatrane stimulated liver regeneration via activation of some components of the protein-synthesizing complex, in particular, aminoacyl-tRNA synthetases. Acylating activity of aminoacyl-tRNA synthetases increased. Possible mechanisms of these changes are discussed.
From 1987 to 1998, examination and treatment were conducted of 12 patients with infectious endocarditis of the tricuspid valve (TIE). 11 of them were operated. TIE was clinically characterized by lesser circulation thromboembolism and marked right ventricular failure. TIE was successfully diagnosed by echo-CG (diagnostic sensitivity 83.3%). Serious disturbances of cellular immunity demanded immunocorrection. Indications for surgical treatment are listed.
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The data obtained showed that the polysaccharide diminished the blood levels of cholesterol, beta-lipoproteins, and triglycerides, the concentrations of cholesterol in the liver and thoracic aorta in experimental atherosclerosis. It is concluded that the polysaccharide is promising in designing a new anti-atherosclerotic drug.
It is shown that the level of DNA, RNA, collagen, non-collagen proteins, hexoses and glycosaminoglycans is changed when making the experimental gastric ulcer in rats. Solcoseryl stabilises the level of DNA, RNA and collagen, stimulating the reparation processes in ulcer.
It was shown that isoproxihermatran (IPH) (40 mg/kg) administered intraperitoneally in rats with lobectomy of heparin stimulates development of hepatocytes' dimensions and decrease of oxygen transmission velocity through the mitochondrial membranes in this cells. Antioxidant properties of IPH have been detected. Stimulating activity of IPH at heparin secretion of bile.
The stimulatory action of Bacillus mucilaginosus exopolysaccharide on proliferative processes in experimental gastric ulcer healing. With the drug, the levels of collagen, noncollagen proteins, glycosaminoglycans, DNA, and RNA in the ulcer tissue.
The study investigated a stimulating effect of tris-[2-hydroxyethyl] ammonium salt of iron-containing polyacryl acid on proliferative processes in the connective tissue in development of experimental gastric ulcer. The drug was found to exhibit an ulcerostatic effect, to change the levels of collagen, noncollagen proteins, glycosaminoglycan fractions, DNA and RNA.
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A stimulating effect of methylethyl(silatrane-I-ilmethyl)-sulphonium iodides, 1-(ethoxy)silatranes and 1-(chloromethyl)silatrane on the processes of rat test acetate ulcer healing is studied. Silatranes efficiency is not inferior to oxyferriscorbone and exceeds that of methacil. It is shown that all preparations inhibit the processes of lipids peroxidation in the blood, in liposomes and stomach tissue.
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