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Biomedical subjects

M M Seredenko

Publications and source records attributed to M M Seredenko.

At least 37 records · Page 2Linked to original sources
PubMed1980

[Effect of acute hypoxic hypoxia on the lung air-blood barrier thickness].

Mean arithmetic and mean harmonic thickness of the lung air-blood barrier (ABB) and its component layers were studied in rats of different age groups normally and after inspiration for 30 min of a gas mixtures of N2 and 11.2% O2 by means of the morphometric analysis of electron microphotographs. Acute hypoxic hypoxia provokes an increase in ABB thickness, more pronounced in younger age groups. The ratio of ABB layers' thickness under hypoxia varied in different age groups. The data obtained suggest age-specific features of the mechanism of arterial hypoxemia development in acute hypoxic hypoxia.

Aging↗
PubMedDate not supplied

[Pathophysiologic mechanisms of cardiorespiratory system dysfunction in high school children with chronic obstructive pulmonary diseases].

The basic indices of the cardiorespiratory system function, gas exchange, regional pulmonary functions have been studied. It is stated that a group of children with a higher level of oxygen consumption (hyperergic type) as against a control group is characterized by disorder in permeability of terminal branches of a bronchial tree, by the development of acute obstructive emphysema, increase in alveolar ventilation with relative decrease in minute blood volume, arterial hypoxemia with possible emergence of tissue hypoxia. A decrease in permeability of large bronchi were observed in a group of children with a low level of oxygen consumption (hypoergic type). Due to this decrease the hypoventilation zones appeared. It caused the development of arterial hypoxemia, but a risk of the tissue hypoxia emergence was insignificant.

Adolescent↗
PubMedDate not supplied

[Lysosomal apparatus of some body tissues in hemorrhage-induced hypoxia ].

The experiments on 40 Wistar male rats with acute circulatory-hemic hypoxia induced by hemorrhage in amount of 15-20% of circulating blood volume were carried out to study the state of lysosomal apparatus of the liver and lung tissues as to changes in activity of acid phosphatase (AP), a marker enzyme of lysosomes. In the case of such a hemorrhage the common activity of AP decreased by 37% in the liver tissue and by 41% in the lung tissue, the free activity increased by 30% and 25%, and bound activity decreased by 84 and 70% in homogenates of the corresponding tissues. Under these conditions the activity of the above lysosomal enzyme in blood plasma became five times as higher as control. A conclusion is made concerning the circulatory-hemic hypoxia influence on the lysosomal membrane's structures of organ's tissues cells (as one can judge by the example of liver and lungs), which is observed in an increase of permeability of lysosome membrane and causes a sharp increase of AP enzymia in blood plasma.

Acid Phosphatase↗
PubMedDate not supplied

[Effect of lipine, a new antihypoxic agent on some respiratory indices in newborn infants after asphyxia].

Lipine, a new antihypoxic drug, has been studied for its effect on respiration and pulmonary gaseous exchange in 47 newborn children, health and with respiratory distress syndrome stresses (SRD) after perinatal asphyxia. It is shown that lipine inhalations cause a considerable increase in duration of respiratory cycle, decrease of respiration frequency, ratio of ispiration di time, to expiration time, increase of alveolar ventilation volume and decrease of respiratory dead space ventilation volume in all lung ventilation volume in newborns with SRD, to a larger degree pronounced in premature children. A conclusion is made on the positive effect of lipine on the state of respiration function and gaseous exchange in lungs in newborn children with symptoms of SRD.

Asphyxia Neonatorum↗