The basic indices of the cardiorespiratory system function, gas exchange, regional pulmonary functions have been studied. It is stated that a group of children with a higher level of oxygen consumption (hyperergic type) as against a control group is characterized by disorder in permeability of terminal branches of a bronchial tree, by the development of acute obstructive emphysema, increase in alveolar ventilation with relative decrease in minute blood volume, arterial hypoxemia with possible emergence of tissue hypoxia. A decrease in permeability of large bronchi were observed in a group of children with a low level of oxygen consumption (hypoergic type). Due to this decrease the hypoventilation zones appeared. It caused the development of arterial hypoxemia, but a risk of the tissue hypoxia emergence was insignificant.

Adolescent↗

PubMedDate not supplied

[Lysosomal apparatus of some body tissues in hemorrhage-induced hypoxia ].

The experiments on 40 Wistar male rats with acute circulatory-hemic hypoxia induced by hemorrhage in amount of 15-20% of circulating blood volume were carried out to study the state of lysosomal apparatus of the liver and lung tissues as to changes in activity of acid phosphatase (AP), a marker enzyme of lysosomes. In the case of such a hemorrhage the common activity of AP decreased by 37% in the liver tissue and by 41% in the lung tissue, the free activity increased by 30% and 25%, and bound activity decreased by 84 and 70% in homogenates of the corresponding tissues. Under these conditions the activity of the above lysosomal enzyme in blood plasma became five times as higher as control. A conclusion is made concerning the circulatory-hemic hypoxia influence on the lysosomal membrane's structures of organ's tissues cells (as one can judge by the example of liver and lungs), which is observed in an increase of permeability of lysosome membrane and causes a sharp increase of AP enzymia in blood plasma.

Acid Phosphatase↗

PubMedDate not supplied

[Effect of lipine, a new antihypoxic agent on some respiratory indices in newborn infants after asphyxia].

Lipine, a new antihypoxic drug, has been studied for its effect on respiration and pulmonary gaseous exchange in 47 newborn children, health and with respiratory distress syndrome stresses (SRD) after perinatal asphyxia. It is shown that lipine inhalations cause a considerable increase in duration of respiratory cycle, decrease of respiration frequency, ratio of ispiration di time, to expiration time, increase of alveolar ventilation volume and decrease of respiratory dead space ventilation volume in all lung ventilation volume in newborns with SRD, to a larger degree pronounced in premature children. A conclusion is made on the positive effect of lipine on the state of respiration function and gaseous exchange in lungs in newborn children with symptoms of SRD.

Asphyxia Neonatorum↗

PubMedDate not supplied

[Compensatory reactions of the oxygen-transport systems of the body with hemic hypoxia (studies on a mathematical model].

The mathematical model suggested by the authors and results of experiments have been used to study the significance of basic oxygen-transport systems in regulation of oxygen conditions of the organism with acute and chronic hemic hypoxia of different seriousness, to determine a relative contribution of each of them to compensation of this hypoxic state, to estimate specific weight of proper "hypoxic" (induced by the effect on oxygen-transport blood function) and "toxic" (caused by the total toxic effect) action of sodium nitrite in the development of hemic hypoxia.

Animals↗

PubMedDate not supplied

[Effect of inhalation of an air mixture with hydrogen sulfide-containing industrial natural gas on glycolysis and lipid peroxidation in rats].

It is shown that inhalation of gas with increased hydrogen sulphide content causes an inhibition of lipid peroxidation, an increase of blood lactate concentration and lactate/pyruvate ratio. Inhalation of hydrogen sulphide leads to inhibition of lipid peroxidation and anaerobic glycolysis.

Animals↗

PubMedDate not supplied

[Two types of gas exchange disorders in children with bronchial asthma].

The main parameters of gas exchange, respiration and hemodynamics have been studied in children aged 9-14 during the acute period of bronchial asthma. Two types of gas exchange disturbances (hyperreactive type characterized by O2 consumption increase, and hyporeactive one--by O2 consumption decrease) have been revealed in the beginning of the acute period. It is shown that by the end of this period the O2 consumption has normalized in children of both groups and has become the same as in in healthy ones. The main pathogenetic mechanisms of hypoxic state development in these two types of gas exchange disturbances are discussed.

Adolescent↗