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M Maienthal

Publications and source records attributed to M Maienthal.

6 recordsLinked to original sources
PubMed1978

Crystal and molecular structure of quinidine.

The structure of the free base quinidine was determined by single crystal X-ray diffraction. Quinidine crystallizes from absolute ethanol as the ethanolate, with the molecular formula C20H24N2O2.C2H6O and molar mass 370.491 units. It crystallizes in the orthorhombic space group P212121 with unit cell dimensions a = 1321.1(3), b = 989.3(2), and c = 1651.5(3) pm. The measured density was 1.15 g/cm3; the density calculated for Z = 4 was 1.164 g/cm3. The diffraction data were collected by using MoKalpha radiation. A final R value of 0.055 was obtained. Evidence for intermolecular hydrogen bonding was found. The crystal analysis is in agreement with the structure proposed by other methods. The absolute configuration is based on the published structure of 10-bromo-10,11-dihydroepiquinidine.

Chemical Phenomena↗
PubMed1977

Mandelonitrile beta-glucuronide: synthesis and characterization.

Mandelonitrile beta-glucuronide, the compound patented as Laetrile, has been synthesized from rabbit liver uridine diphosphate-glucuronosyl transferase immobilized on beaded sepharose, has been analyzed by thin-layer chromatography, nuclear magnetic resonance, and gas chromatography-mass spectrometry, and has been tested for cytotoxicity and mutagenic activity with Salmonella typhimurium strains TA 98 and TA 100. Several commercial laetrile preparations contained no glucuronide; they contained amygdalin and neoamygdalin instead. Mandelonitrile, mandelonitrile glucuronide, and a mixture of amygdalin and neoamygdalin were each found to be mutagenic.

Amygdalin↗
PubMed1977

Synthesis of spin-labeled nitroxyl esters of steroids.

The preparations of spin-labeled nitroxyl esters of prednisone, cortisone, deoxycorticosterone, and cholesterol are described. The ESR spectra indicate that the esters of the three steroids with an oxygen atom at the 11 position have narrower band widths than those with only protons at that position. Mass spectral, chemical, and ESR studies confirmed the structures and purity of the compounds prepared. Reaction of four esters with prednisone antibodies showed reversible binding and large crossover binding.

Animals↗