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PubMed · 335509

Mandelonitrile beta-glucuronide: synthesis and characterization.

C Fenselau·S Pallante·R P Batzinger·W R Benson·R P Barron·E B Sheinin·M Maienthal
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Abstract

Mandelonitrile beta-glucuronide, the compound patented as Laetrile, has been synthesized from rabbit liver uridine diphosphate-glucuronosyl transferase immobilized on beaded sepharose, has been analyzed by thin-layer chromatography, nuclear magnetic resonance, and gas chromatography-mass spectrometry, and has been tested for cytotoxicity and mutagenic activity with Salmonella typhimurium strains TA 98 and TA 100. Several commercial laetrile preparations contained no glucuronide; they contained amygdalin and neoamygdalin instead. Mandelonitrile, mandelonitrile glucuronide, and a mixture of amygdalin and neoamygdalin were each found to be mutagenic.

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AmygdalinMass SpectrometryMutationNitrilesSalmonella typhimuriumJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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C Fenselau, S Pallante, R P Batzinger, W R Benson, R P Barron, E B Sheinin, M Maienthal. 1977-11-11. Mandelonitrile beta-glucuronide: synthesis and characterization.. https://doi.org/10.1126/science.335509

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