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Biomedical subjects

M Marchetti

Publications and source records attributed to M Marchetti.

At least 217 records · Page 12Linked to original sources
PubMed1982

Diagnosis and treatment of preinvasive and microinvasive cervicocarcinoma.

The mortality rate of cervicocarcinoma has significantly decreased over the last few years, thanks to early diagnosis. Prophylactic and therapeutical interventions, at different stages, are therefore necessary to eliminate or, at least, decrease the incidence of this pathology. Between 1975 and 1980, during a cytologic depistage carried out at the Institute of Gynecologic and Obstretic Clinic of Padua University, we examined 72 cases of patients who had undergone the following diagnostic iter: colposcopy, cytology, direct biopsy and conization. Various parameters were analyzed, notably with regard to cases of serious dysplasia, carcinoma in situ, neoplasia with beginning invasion of the glandular necks and microinvasive forms.

Adult↗
PubMed1981

A polymeric film responding in diffusion properties to environmental pH stimuli: a model for a self-regulating drug delivery system.

A new polymeric film, ethylene-vinyl-NN-diethylglycinate random copolymer, has been studied to evaluate possible applications of such a material to produce controlled release dosage forms. Protonation of the substituted amino groups took place to different extents according to environmental pH conditions. The polymeric film proved to be permeable only to uncharged species, the rate of diffusion of which increased with the increasing charge of the membrane. This effect might be related to strong polymer-proton interactions affecting structure and transport properties of the film and enhancing the solvation process. The charged form of a number of barbituric acid derivatives did not diffuse through the membrane. The uncharged forms permeated the polymeric sheeting at rates consistent with their partition coefficients and which increased with the increasing charge of the polymer.

Chemical Phenomena↗
PubMed1981

Biomechanics of sit-up exercises.

Sit-up exercises performed by four male subjects revealed the presence of initial lumbar "hollowing" (lumbar curvature), or trunk hyperextension, or both prior to trunk flexion. Maximum muscular moment developed at the hip joint, which varied with sit-up exercise, was of moderate order of magnitude. Intraesophageal pressure, cardiopulmonary response, and metabolic response to a commonly used sit-up exercise (curl-up) reveals it to be a light exercise which stresses the muscles of the lower limbs as well as those of the trunk, especially the abdominal muscle group.

Abdominal Muscles↗
PubMed1981

[Intermolecular interactions between fluorescent probes bound to linear DNA].

Intermolecular interactions of fluorescent probes bound to linear DNA. Several fluorescent probes can be widely used in determining the base content, the geometry and the possible conformational transitions of linear and circular DNAs in solution. Data are presented showing that Tb3+ and DAPI bind independently to DNA and can therefore be used to monitor the G+C and A+T content of the nucleic acid respectively.

Amidines↗
PubMed1981

[Folate determination in serum for clinical use (author's transl)].

Folate deficiency may be diagnosed in man by measuring serum folate activity using either a microbiological procedure with L. casei or a radioassay. The microbiological procedure tends to be time consuming and tedious, as compared with the radioassay; nevertheless it allows the accurate determination of each folate derivative that is normally present in serum. The comparison of serum folate levels obtained by the two methods shows an adequate correlation. However, it results from individual samples show that the values obtained by the radioassay are lower than the microbiological ones by 10-30%. The lower results in the radioisotope test may be caused by the presence of high levels of unsaturated endogenous protein binders in serum and/or by the difference in affinity of lactoglobulin - the binding protein used in the test - for folic acid (standard) and 5-methyl FH4 or 10-formil FH4 (serum).

Biological Assay↗
PubMed1981

A planned prospective study of combined treatment in stage III epithelial ovarian cancer.

In a planned prospective study 39 consecutive patients with stage III ovarian cancer have been admitted in two years. All patients have received initial extensive surgery followed on as out patients basis by 5 courses of A-Cy chemotherapy and by a second operation and further non cross resistant chemotherapy with Platinum, Hexamethyl-Melamine, Polymelphalan; 24 have been found pathologically free of disease at second surgery, and 34/39 are clinically free of disease while reporting. These data, exactly collected and evaluated are consistent with our (previously reported) empyrical observation that adjuvant surgery interspersed with courses of aggressive chemotherapy may render free of disease the majority of patients, prolong survival, and possibly cure a portion of this population.

Adenocarcinoma↗
PubMed1981

Contact hysteroscopy in the diagnosis of endometrial carcinoma.

The contact hysteroscopy is undoubtedly useful every time an exploration of the uterine cavity is necessary to confirm or deny a diagnostic suspicion. For the typical aspect of the neoplastic lesion which has been confirmed by traditional endoscopy, contact hysteroscopy permits the diagnosis of an endometrial carcinoma with high reliability, modifying the therapeutic approach and consequently the prognosis.

Endoscopy↗
PubMed1981

Fibrinolysis in ovarian cancer.

Coagulation disorders, including thromboembolic phenomena and disseminated intravascular coagulation are recognised as a complication of neoplastic disease. In the present study the Fibrinogen Degradation Products (F.D.P.) were determined in 26 patients with Advanced Ovarian Cancer (stage III and IV FIGO) (mean = 38.1; S.D. = 37.6) and in ten healthy patients considered as controls (mean = 2.7; S.D. = 13). The significative difference (p less than 0.05) between the two groups points in evidence an increasing activation of Ffibrynolytic processes. The F.D.P. determination has revealed a good correlation (p less than 0.001) with the tumor extension as showed by the difference between third stage with large tumor masses (late) (mean = 44.5; S.D. = 24.5) and third stage with minimal residual disease after reductive surgery (early) (mean = 6.7; S.D. = 5.7).

Antithrombins↗
PubMed1981

Carcinoma of the vulva. Non-mutilant surgical therapy, a clinical case.

Radical non-mutilant surgical therapy of the vulva carcinoma; a clinical case. The case of a 30 year old patient affected by invasive carcinoma of the vulva is reported. The patient was submitted to a first operation for tumorectomy with inguinal lymphadenectomy according to the non-mutilant method, and after four months to a further operation for tumorectomy. The treatment was completed with radiant therapy. After three years the patient is living without any illness, and her condition of life is better, compared with the period before surgical intervention.

Adult↗