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Biomedical subjects

M Maru

Publications and source records attributed to M Maru.

34 records · Page 2Linked to original sources
PubMed1983

[Current status of malaria in Ethiopia].

During the least years also in Ethiopia the number of cases of malaria increased despite intensive control measures. There does not yet exist a chloroquine resistance, but, however, special attention must be paid, since it became known from other East-African countries that there were chloroine resistances. DDT has a still sufficient effect. The most important carrier anophelines are A. gambiae S. 1, A. pharoensis, A. funestus and A. nili. M. tropica and M. tertiana nearly exclusively occur. The severest lesions are caused by M. tropica, when it affects malnourished population groups. In contrast to other descriptions a risk of malaria is temporarily existing also at an attitude of more than 2,000 m, though it is here clearly more insignificant than in lower regions. a seasonal accumulation is found from September to November. In contrast to the high rate of incidence of the native population in endemic districts the number of diseases GDR citizens in Ethiopia was extremely low in recent years. Chloroine is further on recommended for medicamentous prophylaxis.

Ethiopia↗
PubMed1982

[Case report of Lyell's syndrome].

In Lyell's syndrome a toxic skin erythema is concerned which leads to the epidermal necrolysis and desquamation. An infantile and an adult form are differed; the latter is usually induced by medicaments. Two patients with apparently medicamentously induced Lyell's syndrome are presented. The evoking medicaments were penicillin and thioacetazone. The two patients showed a severe course with an extensive affection of the body surface. The therapy with glucocorticosteroids, electrolyte substitution and local treatment of the skin lesions was successful in the two cases.

Adult↗
PubMed1982

Characterization of a coronavirus isolated from rats with sialoadenitis.

A causative agent, provisionally designated as CARS, was isolated from the enlarged submaxillary gland of rat which was characterized as a sialoadenitis, using mouse-derived Balb/c3T3 clone A31 (3T3) cell culture. The virus could be propagated in 3T3 cell culture where it produced multinucleated giant cells and formed clear plaques. It was identified as a member of the coronavirus group from the following results: RNA content was suggested by the lack of the effect of cytosine arabinoside, the infectivity was sensitive to lipid solvents and inactivated at 56 degrees C for 5 minutes, the viral particle showed typical coronavirus morphology which was approximately 100 nm in diameter. Serologically, although CARS and sialodacryoadenitis virus (SDAV) actually belonged to the rat-coronavirus group, some antigenic variations existed between these two agents in the results of both neutralization and complement-fixation tests using monovalent antisera. When inoculated intranasally into susceptible rats, CARS caused clinically and histologically overt sialoadenitis as observed in the natural outbreak, and retained its virulence for rats in several passages of mouse brain and even when cell culture was used, while rats which were inoculated with SDAV were asymptomatic.

Animals↗
PubMed1981

Biological properties of plaque-size variants of Sendai virus.

Large (RL)-and small (RS)-plaque variants of Sendai virus were isolated in culture of LLCMK2 cells in the presence of trypsin and their biological properties were determined. The RL variant was more virulent to mice than the RS variant. The RL variant had a higher growth rate than the RS variant in multiple-step growth in the presence of trypsin, but the two variants had an almost equal growth rate in its absence. Restoration of hemolytic activity in cleavage of the F protein of the RL variant were achieved by milder trypsin treatment than was needed for the RS variant.

Animals↗
PubMed1979

Clinical and laboratory features and treatment of visceral leishmaniasis in hospitalized patients in Northwestern Ethiopia.

The clinical and laboratory features, and the response to treatment of visceral leishmaniasis were studied in 18 hospitalized patients. Clinical and laboratory findings were similar to those in patients with kala-azar in the Sudan and East Africa. Fever, heptosplenomegaly, relative lymphocytosis, leukopenia, low platelet counts, and severe anemia were common findings. Pentostam (sodium stibogluconate) was used to treat 17 patients and Neostibosam (ethylstibamine) for one. Three patients died. Four out of the 18 patients had not visited any known endemic area but the significance of this finding has not been fully evaluated.

Adolescent↗