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Biomedical subjects

M Mazurkiewicz

Publications and source records attributed to M Mazurkiewicz.

At least 37 records · Page 2Linked to original sources
PubMed1993

Effects of single and repeated administration of vigabatrin on the performance of non-epileptic rats in a delayed non-matching to position task.

The present experiments were performed to investigate the effects of single and repeated administration of vigabatrin (gamma-vinyl-GABA), a novel antiepileptic drug, on a working memory task (delayed non-matching to position task) in non-epileptic rats. At doses of 100, 300 and 500 mg/kg single administrations of vigabatrin and 50, 100 and 200 mg/kg repeated administrations, vigabatrin did not affect the choice accuracy in the delayed non-matching to position task employing delays of 0, 1, 2, 4, 8 and 16 s, whereas repeated administration with 300 mg/kg and a single dose of 1000 mg/kg decreased the behavioral activity as compared to saline treatment. Previous studies have shown that at doses of 50-200 mg/kg (daily administration) and 200-1000 mg/kg (single administration) vigabatrin has anticonvulsant activity. The present results suggest that vigabatrin does not markedly impair working memory in the low range of antiepileptic/anticonvulsive doses.

Aminocaproates↗
PubMed1993

Further studies on the etiopathology of malabsorption syndrome in broiler chickens.

The paper presents two cases of malabsorption syndrome in broiler chickens. The results indicate that the etiological factor appears to be the virus agent which causes necrosis in extra-excretional parts of the pancreas. During the course of the disease disorders in the enzymatic activity of gammaglutamyltransferase, leucylaminopeptidase and alanylaminopeptidase were observed. It consequently leads to the deterioration of intestines digestion and resorption of feed components. Application of Selcewet-Polfa to the diseased birds improved the health of the birds, morphological picture of peripheral blood and mineralisation of thigh bones. No radical improvement in the compensation of the final body weight was recorded.

Animals↗
PubMed1993

Histological and ultrastructural examination of muscles in broilers administered tiamulin together with ionophoric anticoccidials.

Histopathological and ultrastructural examinations of muscles in broilers, receiving tiamulin and ionophoric anticoccidials were carried out. Myo- and cardiomyopathies, originating from primary mitochondria lesions were followed by ATP deficiency, oedema, degeneration and necrosis of myocytes. This process is reversible and manifested by slow regeneration of muscles.

Animals↗
PubMed1992

Acute effects of gamma-vinyl GABA on the GABAergic system in rats as studied by microdialysis.

The acute effects of the irreversible gamma-aminobutyric acid (GABA) transaminase inhibitor, gamma-vinyl GABA (Vigabatrin), were studied in the central nervous system of the rat. GABA concentrations were monitored in the hippocampus by implantation of microdialysis probes. Two doses of gamma-vinyl GABA (1.6 and 8.0 mM) were administered via the probes and were found to cause a transient increase in the basal GABA outflow (10-fold) during the period of drug administration. In addition, gamma-vinyl GABA pretreatment (1.6 mM) seemed to decrease K(+)-evoked GABA release (P < 0.05). The immediate increase of GABA outflow after gamma-vinyl GABA administration may be the result of direct blockade of GABA uptake sites, a finding which further indicates that the action of GABA transaminase inhibitors may be mediated partly through GABA uptake inhibition.

4-Aminobutyrate Transaminase↗
PubMed1992

Effects of an inhibitor of GABA-aminotransferase (gamma-vinyl-GABA) on the spatial navigation deficit induced by muscarinic blockade.

The present study investigated whether stimulation of the GABAergic system affects spatial navigation [water-maze (WM)] deficit induced by muscarinic blockade (scopolamine). The effects of various doses of gamma-vinyl-GABA (GVG) (50, 150, and 300 mg/kg) and scopolamine (0.4 and 0.1 mg/kg) were examined alone and in combination. GVG at 50 and 150 mg/kg alone did not impair the performance of rats in the WM yask. At 300 mg/kg, GVG caused slight impairment, increasing latency and total distance swim during training trials. Scopolamine at 0.4 mg/kg clearly impaired the performance of rats in the WM task. When the two drugs were coadministered, no interaction between scopolamine and GVG was observed. Our results do not provide support for any interaction between cholinergic muscarinic and GABAergic mechanisms.

4-Aminobutyrate Transaminase↗
PubMed1992

Attenuation by the benzodiazepine receptor antagonist, ZK 93 426, of the deficit in spatial navigation induced by nucleus basalis lesions.

The effects of the benzodiazepine receptor antagonist, beta-carboline ZK 93,426 treatment were studied both in NB-lesioned (ibotenic acid) and in unoperated Kuo-Wistar rats in a water maze task. The ZK 93,426 administered in the doses of 1 and 5 mg/kg, 30 min prior to the testing in a water maze apparatus, attenuated the NB lesion-induced spatial navigation deficit, although it had no effect on the performance of unoperated rats. The results suggest functional interactions between GABAergic system and ibotenic acid-induced lesion of the basal forebrain in rats.

Analysis of Variance↗
PubMed1992

Effects of single and repeated administration of vigabatrin on the performance of rats in a 5-choice serial reaction time task.

The present study investigated whether pharmacological stimulation of the GABAergic system can affect attention. The effects of vigabatrin, a novel antiepileptic drug, on the performance of rats in a 5-choice serial reaction time task assessing selective attention were studied. The effects of acute (100, 300, 500 and 1000 mg/kg) and subchronic (50, 100, 200 and 300 mg/kg/day) administration of vigabatrin were investigated. Previous studies have shown that with acute administration of 300-500 mg/kg or subchronic administration of 50-200 mg/kg/day vigabatrin has anticonvulsant activity. At acute doses of 100 and 300 mg/kg or subchronic administration of 50-200 mg/kg/day vigabatrin had no effect on selective attention. At acute dosing of 500 mg/kg, vigabatrin slightly decreased behavioral activity of rats through decreasing the number of trials completed and percent of correct responses. The highest doses used caused an overall behavioral impairment with no marked depletion of any particular function. The results showed that administration of vigabatrin at antiepileptic doses produced no or slight impairment in attentional function. The deficits seen with higher doses were possibly due to a decrease in behavioral activity.

Aminocaproates↗
PubMed1992

[The value of ultrasound examination for diagnosing postmenopausal metrorrhagia].

The results of transvaginal ultrasound diagnostic assessment of endometrium were compared with histopathological examination of endometrium by following diagnostic abrasion on examined group of 54 postmenopausal women. The method seems to be useful for diagnosis of postmenopausal metrorrhagia, when the "safe" thickness of endometrium layer is taken as 5 mm. It occurs in effect of our study the transvaginal ultrasound examination may decrease the number of subsequent diagnostic abrasions in those cases.

Aged↗
PubMed1991

Increased GABAergic transmission aggravates nucleus basalis magnocellularis lesion-induced behavioral deficits.

Quisqualic acid NBM lesions had no effect on water maze performance, but slightly impaired passive avoidance acquisition. GammavinylGABA treatment alone had no effect on the passive avoidance and water maze performance, but aggravated acquisition deficit in rats subjected to NBM lesioning. However, gammavinylGABA-treated NBM-lesioned rats reached control level of performance.

4-Aminobutyrate Transaminase↗
PubMed1990

[Treatment of neoplastic bony metastasis].

The means and results of treatment of 113 patients with neoplastic metastases into the bone were presented. Conservative and surgical treatment was employed in 65 and 48 patients respectively. The use of bony cement and of connecting elements (so called neoplastic prostheses included) have broaden possibilities of surgical treatment. The pain was reduced usually even eliminated in all the patients. Most of them regained function of the extremity involved, some of them returned to their previous occupation. The longest survival period was observed in patients with kidney cancer metastases.

Adult↗
PubMed1990

[Effect of carotenoids on selected indicators of cellular immunity in cockerels receiving food with high level of vitamin A].

The experiment was carried out on 50 slaughter cocks, aged 5 weeks. The purpose of the experiment was to estimate the effect of beta-carotene and apo-beta-carotenoic acid (10% Carophyll yellow) on some indices of cellular immunity in chicks receiving the feed of high vitamin A content. Chl and NBT proved that carotenoids increased phagocytic activity of neutrophiles in peripheral blood. Similarly, in the case of beta-carotene it was found by blastic transformation test that on 30-40th day of the experiment, the value IS of peripheral blood lymphocytes was increased. On the other hand, chicks fed apo-beta-carotenoic acid showed such an effect on 40th day of observation only in the case when the lowest dose of preparation (24 mg/kg of feed) and Con A as mitogen were applied. In each experimental group, the chicks exhibited increased flavin content in liver and markedly increased retinol content due to apo-beta-carotenoic acid (24 mg/kg of feed). On the other hand, the contents of alpha tocopherol and ascorbic acid did not show significant differences between experimental and control groups. Similar were the results with iron, zinc and magnesium. Copper content of the liver was markedly increased in the birds receiving apo-beta-carotenoic acid in the dose of 24 mg/kg of feed. The increased content of manganese was observed in the liver of birds receiving beta carotene (6 mg/kg of feed).

Adjuvants, Immunologic↗
PubMed1987

Activity of some hydrolases in mice with transplantable lymphatic leukemia P 388.

Mice--BDF, hybrides, males aged 3 months were injected intraperitoneally with 10(4) lymphatic leukemia cells P 388. The mice were killed by bleeding after 2.5 and 10 days after the injection. Gamma-glutamyltransferase (GGT), leucylaminopeptidase (LAP) and cobalt activated acylase activity were determined in the serum of the mice. The inner organs of the animals were verified histopathologically. A statistically significant increase in the activity of the examined enzymes was observed together with the development of transplantable leukemia. These enzymes can be helpful in early monitoring of lymphatic leukemia P 388 in mice--as markers of cancer growth.

Amidohydrolases↗