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Biomedical subjects

M McKelvie

Publications and source records attributed to M McKelvie.

5 recordsLinked to original sources
PubMed1996

Improving the early detection of malignant melanoma.

The early detection of cutaneous melanoma is known to be associated with reduced mortality. In order to improve early detection of suspicious skin lesions a Pigmented Lesion Clinic (PLC) was set up at Mount Vernon Hospital in January 1993. Its aims were to provide a rapid method of expert assessment and treatment for malignant skin tumours as well as reassurance for patients with benign lesions. In the first 2 years, 1779 new patients were seen and 674 lesions excised, of which 18% were malignant. Comparison of the Breslow thicknesses of melanomas diagnosed via the PLC revealed a significant shift towards thinner early tumours when compared with the two previous years (chi 2 = 12.8, P < 0.01) and during the same time period via normal routes of referral (chi 2 = 8.68, P < 0.02). The running of such a service and its hidden benefits are discussed.

England↗
PubMed1993

Problems in the case for psychotherapeutic integration.

The arguments in favor of therapeutic integration are summarized and evaluated. Weaknesses of the position are: (1) the false claim that all therapies are equally effective; (2) the lack of a clear and accurate specification of what makes a school of therapy "legitimate"; (3) the lack of a clear case for an accurate and comprehensive list of common elements across therapies; (4) a lack of clarity concerning "clinical strategy"; (5) the incorrect claim that cognitive therapy provides a useful and neutral meta-language; (6) inadequate evidence of trends toward integration; (7) fallacious reasoning based on these alleged trends; and (8) a misunderstanding of the history and philosophy of science.

Behavior Therapy↗
PubMed1985

An effect of ischemia on myocardial dihydropyridine binding sites.

The [3H]nitrendipine binding activity of sarcolemmal fragments isolated from aerobically perfused or ischemic rat hearts was studied. After 90 min aerobic perfusion, two populations of binding sites were detected--high affinity sites with KD of 0.24 +/- 0.04 nM and Bmax 313 +/- 110 fmol/mg protein, and low affinity sites with KD of 47.6 +/- 8.7 nM and Bmax 12.4 +/- 1.88 pmol/mg protein. Sixty minutes global ischemia significantly reduced the KD of the low (15.8 +/- 2.9 nM, P less than 0.03) but not of the high (0.22 +/- 0.05 nM) affinity sites. Under these same conditions the Bmax of both the high (82.4 +/- 14.5 fmol/mg protein, P less than 0.03) and low (6.1 +/- 1.7 pmol/mg protein, P less than 0.01) affinity binding sites was reduced but the sites retained their selectivity, with nifedipine displacing bound [3H]nitrendipine more potently than D600. Bay K 8644, when added upon reperfusion, promoted a dose-related increase in Ca2+ entry which was reduced by nifedipine, indicating that dihydropyridine binding sites can be activated after 60 min ischemia.

3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethy↗