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Biomedical subjects

M Melato

Publications and source records attributed to M Melato.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

Myocardial ischemia in Vaquez's disease.

The authors report a study performed on the ECG findings in patients affected by polycythemia rubra vera. Clinicopathological correlations are made on the basis of autopsic examinations of 11 of these patients (out of the 21 subjects studied). The clinical investigation was performed on the ECG findings according to the Minnesota Code; pathologic investigation pointed out some particular lesions of myocardial district, as myocardium sclerosis, acute infarction, post-infarction scars, vascular lesions of the macro- and microcirculation. The results showed that ECG and the pathological findings in polycythemia vera appear to have a physiopathologic background although the latter is not linked to a well-defined anatomopathologic picture.

Aged↗
PubMedDate not supplied

Amyloidosis and lung cancer. A morphological and histochemical study.

A study performed on a sample of 120 subjects who died of lung carcinoma and were examined at autopsy in order to verify the presence of amyloid substance particularly localized in the tumoral tissue, is reported. In the positive cases (4 oat cell carcinomas and 1 squamous cell carcinoma), the histochemical nature of depositions was investigated to assess their belonging to the primitive or secondary type, and to the APUD or immune type. The doubtful results induced the authors to suppose an analogous behaviour of oat cell carcinoma and squamous cell carcinoma. The explanation of this phenomenon is still unclear and it should be looked for starting from two hypotheses: an analogy between oat cell carcinoma and squamous cell carcinoma both belonging to the APUD system, or simply a non-specific phenomenon (intratumoral amyloid deposition).

Adenocarcinoma↗
PubMedDate not supplied

[Carcinoid cardiopathy. A study of 40 cases].

Carcinoid is a slowly growing type of tumor; its pathological effects are primarily due to its endocrine symptomatology. Among the main causes of death are heart failure, liver disease and complications due to the tumor size. The purpose of this study was to investigate carcinoid heart disease in a wide necropsy sample. We analyzed 26,921 necropsies performed at the Institute of Pathology of the University of Trieste from January 1, 1976 to December 31, 1985. Out of the 26,921 necropsies we found 59 cases with carcinoid tumor. It is interesting to underline the presence of a second primary tumor in 28.8% of cases and of multiple tumors in 2 cases. In the heart we observed valvular abnormalities with no peculiar features in 16.1% of cases, ischemic heart disease in 52.2% and endocardial thickening in 15.9%. Our series, although rather large, did not show the high frequency of carcinoid heart disease that has been reported by other authors; instead, we observed a rather high prevalence of lesions typical of ischemic heart disease. The endocardial thickening seems to be the most interesting and specific finding.

Adult↗
PubMedDate not supplied

[Computed tomography and magnetic resonance in the preoperative staging of the spread of rectal cancer. A correlation with the anatomicopathological aspects].

In order to assess the accuracy of CT and MRI in evaluating the local extent of rectal carcinoma, 22 patients with a rectoscopic diagnosis of rectal cancer were examined before surgery with both techniques. Tumor extent into the perirectal fat, involvement of surrounding structures and local adenopathy were evaluated on both CT and MR images. These findings were compared with the micro- and macrohistologic findings obtained from the surgical specimens. As far as perirectal fat infiltration is concerned, the diagnostic accuracy of CT was 73% and that of MRI was 71%. Sensitivity was 100% for CT and 91% for MRI, while specificity was low for both techniques (45% for CT and 50% for MRI). In evaluating local adenopathy, CT accuracy was 82% and MR accuracy was 90%, with 89% sensitivity for both techniques and 77% specificity for CT and 92% for MRI. The overall accuracy was 59% for CT and 67% for MRI. In agreement with literature data, our study shows a similar accuracy for CT and MRI in evaluating the local extent of rectal carcinomas. Moreover, our results confirm the value of macrohistology in the local staging of rectal carcinoma and its prognostic value, as well as the low specificity of both CT and MRI in evaluating lesion spread into the perirectal fat.

Aged↗
PubMedDate not supplied

The schwannoma: an uncommon type of cystic lesion of the pancreas.

Schwannomas of the pancreas are rare and their number is lower than is usually reported in the literature since some were probably neurofibromas. We report a further case characterized by cystic feature, clinically mimicking a pancreatic pseudocyst. Cystic lesions of the pancreas also comprise the schwannomas, both benign or malignant, as has been previously reported and is stressed by the present case. Cyst formation characterizes many diseases of the pancreas, both neoplastic and not. Difficulties in the differential diagnosis of cysts are fortunately reduced by the preponderance of pseudocysts (i.e. non-neoplastic cysts) and, among neoplastic ones, of cystadenomas and cystadenocarcinomas. As a consequence, uncommon cystic neoplasms are neglected and very often misdiagnosed. We reported a case of solitary schwannoma mimicking a pancreatic pseudocyst, interesting both because of its rarity and because of its cystic feature which was previously reported in the literature but not emphasized.

Aged↗
PubMedDate not supplied

Proliferating cell nuclear antigen (PCNA) as a prognostic factor for colorectal cancer.

PCNA (proliferating cell nuclear antigen) is a cell cycle related protein that is maximally elevated in late G1 and S-phase of proliferating cells. 114 biopsy specimens of colorectal cancer were immunolabeled with PC 10 which specifically recognizes PCNA; Dukes' staging and histological grading were estimated for each case. All patients were followed-up for at least 60 months or to death. All data were analysed by the computer program NCSS (Number Cruncher Statistical System). According to the results, PCNA-index may be considered an independent prognostic factor for colorectal cancer; it may also be helpful in supporting the therapeutic strategies based only on Dukes' stage.

Colorectal Neoplasms↗