[Splenic lymphangiomas associated with polycystic liver and kidneys (author's transl)].
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Cysts↗
Biomedical subjects
M Melato
Publications and source records attributed to M Melato.
[Endoscopic & histopathologic features of esophageal ulcers. Considerations in 13 cases].
Chronic, severe reflux esophagitis can be complicated with an esophageal ulcer (EU), whose histomorphological characteristics change sensibly. Between 1983 and 1989, 18 EU were endoscopically identified in 13 (6%) out of 217 patients with chronic gastroesophageal reflux (GER). 2 groups were defined: EU and esophagitis, without columnar-lined esophagus and EU with localized columnar metaplasia or Barrett's esophagus. In the first, 4 Wolf's ulcers (WU) were present; in the second, there were 8 Barrett's ulcers (BU), 2 Savary's ulcers (SU) and 4 ulcers with intermediary characteristics (IU). The 24 h esophageal Ph monitoring demonstrated the reflux pathogenesis in all the patients (57%: alkaline reflux). The histomorphological findings of the EU could support the hypotesis that their variety is related to the different stage of the reflux disease. The EU, started as a peptic lesion on a stratified squamous mucosa (WU), due to an acid, alkaline or mixed reflux, would macroscopically turn into a BU, through intermediary entities (SU, IU), with a progressive extension of columnar metaplasia to the adjacent epithelium and walls. It's not possible to exclude the primitive development of the BU in a Barrett's mucosa, because of an alkaline reflux or because of a low mucosa's resistance (specialized columnar epithelium) to a prolonged acid exposure.
Adult↗
Gastric cancer and flow cytometry: the beginning of a promising match.
Gastric cancer (GC) is still a diffuse and aggressive disease in many countries where its frequency has not drastically decreased as in the USA. Furthermore, except in Japan and few other countries where the health care system has implemented effective strategies to diagnose the disease very early, GC therapy is unsatisfactory because of the advanced stage at which it is disclosed. Recent advances in the understanding of GC, resulting from identification of Helicobacter pylori as a critical factor in its development, seem not to have changed the situation. Studies on GC have often adopted flow-cytometry to investigate many parameters mostly related to prognosis. Unfortunately, the results obtained with this important technique have been disappointing and diverse, which has caused a fair amount of skepticism as to its role. Starting from a critical review of the vast Literature on the topic, this paper discusses a re-evaluation of the role of flow-cytometry in the fight against GC.
Carcinoembryonic Antigen↗
Epidermal growth factor-receptor expression correlates with tumor cell proliferation and prognosis in gastric cancer.
Currently, the most accurate prognostic indicator in gastric cancer is stage. Studies on proliferating cell nuclear antigen (PCNA) in gastric cancer have demonstrated that the PCNA labeling index correlates with depth of invasion, organ metastasis, vascular invasion, and tumor stage, suggesting that this marker may be a valuable prognostic factor. Epidermal growth factor (EGF) promotes the growth of cells of both ectodermal and mesodermal origin, and plays an important role in cellular proliferation and differentiation. Furthermore, there has been increasing evidence that growth factors and their receptors are involved in carcinogenesis. The aim of this study was to investigate the correlation between expression of the EGF-receptor (EGF-r) and proliferative activity (PCNA labeling index) in gastric cancer by immunohistochemical analysis. Our preliminary results on 56 gastric cancers indicate that the PCNA labeling index correlates with EGF-r immunoreactivity. Furthermore, survival was significantly lower in patients with EGF-r positive tumors and a high PCNA labeling index. These in situ observations suggest that EGF-r may play an important role in the growth regulation of human gastric carcinomas.
Adult↗
Non-Hodgkin's lymphoma (NHL) of the oral cavity.
BACKGROUND: The treatment of NHL in the head and neck region is complex because of the numerous variables that are involved. Reports in the recent literature on NHL of the oral region have dealt with one or two individual cases and routine treatment guidelines do not exist. Local lesions are responsive to radiotherapy as well as to chemotherapy, but the cure rates are discouragingly low. PATIENTS AND METHODS: We report a case of a painful swelling of the lower left gingiva. Local biopsy and a systemic work-up (labs, x-rays, eco scan, CT, bone marrow aspiration and biopsy) was performed. RESULTS: The biopsy of the oral lesion disclosed a malignant NHL; other examinations failed to find other foci of the lymphomatous process. CONCLUSIONS: This case of primitive NHL of the oral cavity summarises the main characteristics of this rather uncommon pathology: a) difficult diagnosis at presentation, often misdiagnosed for other more common oral diseases b) the importance of a local biopsy; c) rapid evolution; d) a good response to chemotherapy; e) poor prognosis.
Antineoplastic Combined Chemotherapy Protocols↗
Comparison of microvessel density with tumor associated macrophages in invasive breast carcinoma.
Neovascularization, the growth and formation of capillary blood vessels, is an essential component of solid tumor growth and a critical step in metastasis. Tumor associated macrophages (TAMs) have several functions related to tumor biology including growth, proliferative rate, stroma formation and dissolution, and neovascularization. The aim of this study was to define the TAM and microvessel density (MD) in human invasive breast carcinoma NOS and to correlate their values with lymph node status, tumor size, tumor grade and mitotic activity index (MAI), and, finally, to determine whether MD is connected with TAMs. A total number of 57 invasive breast carcinomas NOS were processed for immunohistochemical analysis using mAb to F-VIII to visualize endothelial cells and mAb to CD68 antigens for macrophages. Statistical analysis showed only a positive correlation between TAMs and MAI (p = 0.004). These results support the notion that intensity of tumor angiogenesis does not provide additional prognostic significance, while TAMs may play a positive role in breast cancer micro system since they regulate tumor proliferation.
Biomarkers↗