Biomedical subjects

M Mukherjee

Publications and source records attributed to M Mukherjee.

111 records · Page 7Linked to original sources

PubMedDate not supplied

Effect of flutamide on the physiological status of epididymis and epididymal sperms.

Flutamide, a pure antiandrogen, increases the levels of plasma luteinizing hormone but antagonizes the biological expression of androgen on target organs. Flutamide was administered to rats to study the effect of altered availability of hormones on the functional status of epididymis. The weights of ventral prostate, seminal vesicles and epididymis showed antiandrogenic effects of flutamide. However, increased activity of kidney beta-glucuronidase reflected increased availability of testosterone. The concentrations of protein and DNA along with the activities of acid phosphatase and hyaluronidase decreased in flutamide-treated rats. The activities of acid phosphatase and hyaluronidase in epididymal sperms along with protein concentration increased in flutamide-treated rats. Alteration of epididymal function by treatments affecting lysosomal stability was indicated.

Acid Phosphatase↗

PubMedDate not supplied

Correlation of circulating 17beta-oestradiol with haemostatic factors in healthy postmenopausal women.

The aim of the study was to evaluate any correlation between the circulating oestrogenic hormone 17beta-oestradiol and haemostatic factors in healthy postmenopausal women. In keeping with this objective, the correlations were evaluated irrespective of whether the source of the hormone was purely endogenous or exogenous as well. Accordingly, a univariate correlation adjusted for age, body mass index, and duration of menopause was determined in 42 healthy postmenopausal women aged 47-78 years, 19 of whom were self-reported users of hormone replacement therapy. The rest were self- reported never users. Serum 17beta-oestradiol exhibited a direct correlation with endogenous thrombin potential extrinsic pathway (R = 0.42, p = 0.01) and prothrombin fragments 1 and 2 (R = 0.37, p = 0.03) and an inverse correlation with antithrombin III (R = -0.36, p = 0.03) and alpha(2)-antiplasmin (R = -0.45, p = 0.005). The observations suggest an association of this hormone with net thrombin generation on the one hand and improved fibrinolysis on the other.

Adult↗

PubMedDate not supplied

Platelet adhesiveness in coronary heart disease.

A simple reproducible method of determination of whole blood platelet adhesiveness, on columns of unsiliconised glass microbeads, was developed and validated. Platelet adhesiveness was determined in 180 subjects who were classified into four groups. The subjects of Groups I and II had negative cardiac stress and were free from coronary heart disease (CHD). While the 42 subjects of Group I had none of the conventional coronary risk factors, the 46 subjects of Group II had one or more coronary risk factors. Group III consisted of 68 subjects who had positive cardiac stress test. They were patients with myocardial ischemia. Group IV consisted of 24 survivors of myocardial infarction. The percent of subjects with platelet retention values exceeding 50.5% were, 9.5% in Group I, 26.1% in Group II, 32.4% in Group III and 37.5% in Group IV (p < 0.05). Although Group II consisted of subjects free from CHD, its difference from Group I, and closeness to Groups III and IV probably indicate that asymptomatic subjects with coronary risk factors and with increased platelet adhesiveness may be on the threshold of the symptomatic phase of CHD. Increased platelet adhesiveness may thus be a predictive marker of CHD.

Adult↗