Several derivatives of 2-methylthiobenzimidazoles were synthesized and assayed for anthelmintic activity. Following these studies, 2-methylthio-5-(1-chloronaphthyloxy-2)-6-chlorobenzimidazole (G-1557) has been selected as a tichinellacide for detailed investigations.

Animals↗

PubMedDate not supplied

[The technology for manufacturing antiparasitic preparations. 4. The development of a technology for producing the anthelmintic bromoksan in finely dispersed form and the evaluation of its antifascioliasis activity].

A manufacturing procedure has been developed to prepare the anthelmintic bromoxane as a finely divided dosage form. The maximum toxic dose of the drug was 1 g per kg mice body weight. Its therapeutic dose in sheep fascioliasis was 20 mg/kg.

Animals↗

PubMedDate not supplied

[A comparative study of the efficacy of medamine, albendazole and embovin in models of syphaciasis and aspiculariasis].

The study covers the study of three antinematodal agents: the original national drug medamine with albendazole and embovin (pyrathel pamoate), which have been reproduced at the E. I. Martsinovskiĭ Institute of Medical Parasitology and Tropical Medicine, with murine Syphacia obvelata and Aspiculuris tetraptera infection models. The quantitative parameters of the anthelmintic action of medamine, albendazole and embivin were comparatively defined for the first time.

Albendazole↗

PubMedDate not supplied

[The search for new antiparasitic agents. 13. The synthesis and study of the acute toxicity and antihymenolepiais activity of a new derivative of isoquinoline-[2,1-D] [1,4]-benzazepine].

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Animals↗

PubMedDate not supplied

[The search for new antiparasitic agents. 12. The synthesis and study of the anti-Echinococcus and anti-Hymenolepis activity of 6-[4-(4-alkylpiperazinyl-1)-phenylamino]-1,2,5-thiadazolo[3 ,4-h] quinolines].

The paper describes the synthesis of 6-[4-alkylpiperazinyl-1)phenylamino]-1,2,5-thiadiazolo[3,4-h ]quinolines where methyl (Drug G-1574) and ethyl (Drug G-1569) are alkyls. The two agents are as effective as mebendazole against the larval stage of Echinococcus multilocularis infection. Drug G-1574 has been demonstrated to ensure 100% recovery of spontaneously Hymenolepis nana-infected albino mice given doses 2.5-5 times lower than the effective dose of phenasal (niclosamide).

Animals↗

PubMedDate not supplied

[The technology for manufacturing antiparasitic preparations. 3. The development of a technology for producing the anthelmintic embovin (pyrantel embonate) in finely dispersed form and the evaluation of its anthelmintic properties].

Manufacturing process for anthelmintic embovin in a micronized form have been developed. Embovin in the micronized form exhibited the highest activity.

Animals↗

PubMedDate not supplied

[Tegalid distribution in the body of rats].

Pharmacokinetic studies of a new anthelminthic tegalid, made in this country, were carried out. The drug concentrations in biologic material were measured by high-pressure liquid chromatography. The drug was found to circulate for a rather long time in the blood, virtually not accumulating in any of the examined organs, except the liver. Tegalid pharmacokinetics can be fairly well approximated by a unicompartmental model with due consideration for its absorption.

Administration, Oral↗

PubMedDate not supplied

[The synthesis and study of the acute toxicity and anthelmintic activity of salicylanilides containing a quinoline residue].

Salicylanilides containing quinoline moiety were synthesized and examined for acute toxicity and antinematodal activity. All the compounds were shown to possess a low toxicity. In the trials on a nematodal model (Aspiculuris tetraptera, white mice), 2 compounds--G-1570 and G-1575--were shown to be highly effective.

Animals↗

PubMedDate not supplied

[The technology of manufacturing antiparasitic preparations. The development of a technology for obtaining the anthelmintic tegalid in a finely dispersed form and the evaluation of its antifascioliasis and antidicrocoeliasis activities].

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Animals↗