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M Nowaczyk

Publications and source records attributed to M Nowaczyk.

83 records · Page 5Linked to original sources
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Beta 3 integrin expression on T cells from renal allograft recipients.

Recent studies emphasize the paramount significance of beta 3 integrin in cell adhesion and homing, which may be particularly relevant in cancer progression and metastasis. In contrast, the presence and potential role of beta 3 on human T cells is practically unknown. We show that T cells can express significant amounts of alpha-beta 3 integrin (CD41/CD61), and the expression of alpha(v)-beta 3 (CD51/CD61) remains very low. T-cell beta 3 integrin is probably transferred by platelet-derived microparticles.

Antigens, CD↗
PubMedDate not supplied

Bacteriophages and transplantation tolerance.

Our recent findings suggest that bacteriophages (phages) may not only eliminate bacteria, but also modulate immune functions. In this communication, we demonstrate that phages may strongly inhibit human T-cell activation and proliferation as well as activation of the nuclear transcription factor NF-kappaB in response to a viral pathogen. Phage administration in vivo can diminish cellular infiltration of allogeneic skin allografts. Thus, phage treatment should be considered in antibiotic-resistant posttransplantation infections. Furthermore, phages could find a broader application in clinical transplantation.

Animals↗
PubMedDate not supplied

Ethanol facilitation of short-term memory in adult rats with a disturbed circadian cycle.

The aim of this study was to evaluate the effect of 3-month ethanol treatment on olfactory social memory test performance using two inter-exposure intervals [30 min: short-term recognition (STR); or 120 min: long-term recognition (LTR)] in adult rats with a disturbed circadian cycle (DCC). Ethanol treatment both in ethanol-preferring and -non-preferring groups improved the STR task compared to control rats. However, LTR procedure triggered the opposite tendency. Moreover, no differences between control rats with DCC and those with normal diurnal rhythm in STR and LTR paradigms were observed. Our results suggest that, under some conditions, alcohol facilitates short-term memory in adult rats.

Analysis of Variance↗
PubMedDate not supplied

Interleukin 2 receptor positive T lymphocytes in renal allograft recipients: association with CMV infection.

The number of interleukin 2 receptor positive T cells freshly isolated from peripheral blood as well as stimulated in culture with PHA was determined in renal allograft recipients with stable graft function, rejection and CMV infection. The most typical phenotype was observed during CMV infection. Patients with CMV had very low levels of circulating positive cells which responded normally to mitogen stimulation in vitro.

Cytomegalovirus Infections↗