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Biomedical subjects

M Onder

Publications and source records attributed to M Onder.

25 records · Page 2Linked to original sources
PubMed1999

Bilateral nipple hyperkeratosis treated successfully with topical isotretinoin.

A 22-year-old woman presented with bilateral thickening and hyperpigmentation of her nipples since the age of 17 years. There was no history of pregnancy or oral contraceptive pill use. Isotretinoin 0.025% gel was applied twice daily and the lesions disappeared in 4 weeks. After the drug was ceased, recurrence appeared within 4 months. The same therapy, applied for 2 weeks, again cleared the problem.

Administration, Cutaneous↗
PubMed1994

Natural cellular cytotoxicity in Behçet's disease.

This study evaluated the cytotoxic activity of natural killer cells in the active and inactive stages of Behçet's disease (BD) and attempted to develop a new explanation for its immunopathogenesis. Blood samples were taken from 16 BD patients and compared with 11 healthy individuals. The lymphocyte fraction was separated and diluted in RPMI-1640. Candida as a target cell (T) was mixed with lymphocytes (E) (effector cells) in ratios of T:E 1/5 and T:E 1/25. After the numbers of colonies were counted with controls, the anticandidal index (natural cytotoxicity) was calculated. Natural cytotoxicity relatively decreased in the active stage and increased in the inactive stage of BD. Although the difference between the mean value of natural cytotoxicity in the active stage and in the inactive stage was significant, the difference between the averages of active stage and the control group was insignificant. However, the difference between inactive stage and the control group was remarkable. The increase of the natural cytotoxic activity in the inactive period of the disease may play a role together with other immune mechanisms in the aetiopathogenesis of BD.

Adult↗
PubMed1994

The effect of propofol on systemic vascular resistance during cardiopulmonary bypass: a comparative study with thiopentone.

30 patients undergoing elective coronary artery bypass grafting surgery were allocated randomly to receive either propofol--2.5mg/kg--(N = 10, Group I) or thiopentone--4mg/kg--(N = 10, Group II) during cardiopulmonary bypass with constant pump flow and temperature. Two groups and another control group-receiving no medication-(N = 10, Group III) were compared with respect to the changes in hemodynamic parameters, especially systemic vascular resistance (SVR). After propofol, SVR decreased from 2489 +/- 302 to 1594 +/- 286 dyn sec cm-5 and remained significantly less than the control values until 16.6 +/- 4 min. after the administration of propofol. Following thiopentone administration, SVR decreased from 2653 +/- 298 to 2162 +/- 279 dyn sec cm-5 and remained so for the following 9.4 +/- 3 min. There were more significant decreases in especially cardiac index, perfusion pressure and SVR in the propofol group compared with thiopentone or control groups. Cardiopulmonary bypass has been shown to be a useful model for studying the isolated effects of anesthetic drugs on hemodynamic parameters. In our study, we tried to discuss the mechanism of the hypotensive effects of anesthetic agents, especially propofol and give an idea about the possible precautions that should be taken.

Adult↗