Identification of carriers of the Welsh CASA1 variant using an allele-specific PCR method.
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Alleles↗
Biomedical subjects
M Pappalardo
Publications and source records attributed to M Pappalardo.
A BalI RFLP at the goat beta-casein gene.
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Animals↗
Synthesis of some derivatives of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(piperazin-1-yl)-3-quino linecarbo xylic acid (norfloxacin) as potential antibacterial agents.
Twelve new fluoroquinolones, structurally related to norfloxacin, have been synthesized in order to investigate the effect of substituents at the secondary nitrogen of the piperazine ring on antimicrobial activity. The new substances (carbamates, isoureas, guanidines, ureas and cyanamides) tested on a variety of gram-positive and gram-negative organisms showed lower activity than the model compound.
Anti-Bacterial Agents↗
Synthesis and calcium antagonistic activity of a new class of 1,4-dihydropyridines having an alkoxyimino group in position 3.
The synthesis of new 1,4-dihydropyridines having an alkoxyimino group in position 3 is described. Pharmacological evaluation included calcium antagonistic activity in the guinea pig Taenia coli test, acute toxicity and oral antihypertensive activity in SHR. The compounds had a remarkable calcium antagonistic activity in vitro and low toxicity, but no antihypertensive activity in vivo, probably due to an unfavourable pharmacokinetic profile.
Animals↗
Echographic imaging with dynamically focused insonification.
This work describes a real-time echographic imaging device with lateral scanning and a new process for dynamic focusing. While, in reception, a time varying focus is a well-established process, the system that we propose is able to perform dynamic focusing also in transmission. This is carried out by emitting several acoustic pulses focused in different regions. This process, which we call dynamic focused insonification, gives good results and can be used either alone or in connection with dynamic focusing in reception.
Image Enhancement↗