[Bilateral hearing in patients with temporal epilepsy with or without verifiable lesions].
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Adult↗
Biomedical subjects
M Parma
Publications and source records attributed to M Parma.
[Spinal meningioma as a frequently unrecognized cause of neuromotor disorder in the aged].
The clinical history prior to surgery of 18 cases of spinal meningiomas is examined. In most cases, surgical management had been undertaken too late and the reasons for this are discussed. Poor neurological knowledge on the part of general practitioners or mistaken interpretation of the initial symptoms by specialists were the main causes. Persistent prejudices based on the supposed damage caused by myelographical investigation also proved a stumbling-block to timely intervention.
Adult↗
[Erythrocyte changes (echino- and stomatocytic) in muscular dystrophy: research on possible applications in diagnosis and eugenics].
The Authors, after a brief review of the factors which influence the echino and stomatocytic erythrocyte's deformations and of the biochemical basis of these alterations, report the comparative study of the echino-stomatocytogenesis in both normal subjects and myodystrophic patients. In order to investigate whether this phenomenon is more developed in pathological condition, the results confirm that between normal subjects and myodystrophic patients or healthy carriers there is a quantitative significant difference which can be utilized for diagnostic and eugenic purposes. To obtain reliable results, the evaluation should be made at regular intervals of time from the blood drawing and after the exclusion of the presence of other disease or echino-stomatocytogenetic factors (drugs, etc.).
Acanthocytes↗
[Memory function following episodes of transitory total amnesia].
The Authors, considering the insufficiency of data in this condition, have studied the memory functions in patients who, in the follow up after an episode of TGA, did not show any clinical sign. A selective loss of a short-term "verbal" memory, without any psychometric alteration, is found out. The meaning of those observations is discussed with regard to the possible further differentiation of TGA syndrome in acute and chronic phases.
Amnesia↗
[Clinical and muscle istochemical observations in secondary hypokalaemia (author's transl)].
A case of hypokalaemia due to chronic administration of Clortalydone is reported. The histochemistry of muscle biopsy showed the morphologic changes which are usually found in the muscle fibers of periodic familial paralysis (necrotic fibers, accumulation of PAS positive substance, inflammatory cells, intermyofibrillar network degeneration, increase of lipids content). Such findings suggest some clues to the pathophysiology of the essential hypokalaemic paralysis and the possible practical importance of these histopathologic muscular findings in the diagnosis of secondary hypokalaemia.
Aged↗
[Cutaneous perception of figured tactile stimuli in humans under normal conditions].
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Female↗
[Cerebro-cardiac syndromes: the problem of the possible pathogenic effects of cerebral lesions on cardiac activity].
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Arrhythmias, Cardiac↗
[The Steele-Richardson-Olszewski syndrome (or "progressive supranuclear palsy")].
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Central Nervous System Diseases↗
Hemispheric prevalence changes in partial epileptic patients on perceptual and attentional tasks.
In relation to the general issue of the long-term effects of epileptic activity on the higher nervous functions, monohemispheric epileptic patients--divided into "lesional" [i.e., with computed tomography (CT) scan-visible lesions] and "nonlesional" (i.e., with CT scan-nonvisible lesions)--were submitted to dichotic verbal and tonal tasks, dichoptic verbal and spatial tasks, and a visual tachistoscopic attentional task. The aim was to investigate whether the typical patterns of hemispheric prevalence, which were observed in normal subjects by using these tests, undergo significant changes in epileptic patients. The findings versus normal subjects seem to demonstrate that (a) in lesional epileptic patients, the prevalence of the hemisphere without macroscopic lesions is a constant rule, whether or not this hemisphere is prevalent in normal subjects; (b) in nonlesional epileptic patients, the patterns are the following: when the epileptic hemisphere is the one that is prevalent in normal subjects, its prevalence is enhanced, whichever the hemisphere; when the epileptic hemisphere is not the hemisphere prevalent in normal subjects, the left one attracts and maintains prevalence, whereas the right one reduces and variously interferes with contralateral prevalence. It is concluded that, with respect to the functions tested, the nature of the epileptic foci seems to influence markedly the interhemispheric prevalence pattern.
Adult↗
Mechanisms of paraneoplastic syndromes in mice bearing a spontaneous lung adenocarcinoma.
Paraneoplastic syndromes are rarely described in animal models. It may be useful to have a suitable experimental model to study the mechanisms by which they are produced. In this study, we describe a murine lung adenocarcinoma, P07, which presents hypercalcemia, leukocytosis and cachexia. We determined the presence of PTHrP in plasma as well as GM-CSF produced by P07 cells. TNF-alpha, which is responsible for cachexia, could neither be detected in serum nor in P07 cell supernatants. We conclude that this model, which shows paraneoplastic syndromes similar to those of lung tumor patients, should be useful to study the pathways and significance of these signs.
Adenocarcinoma↗
Immune reactivity during the growth of a murine lung adenocarcinoma: evaluation of paraneoplastic syndrome development.
The purpose of this study was to investigate if specific immune responses were present in mice bearing a lung adenocarcinoma that presents paraneoplastic syndromes during tumor evolution. Leukocytosis, mainly due to polymorphonuclear leukocytes, was found from day 15 of tumor growth. Delayed type hypersensitivity response and increased interleukin-6 (IL-6) serum levels were observed along tumor growth. Concomitant immunity, specific rejection of a second inoculum and in vitro specific cytotoxicity occurred at 20 days of implant. In advanced stages of tumor evolution impaired cytotoxicity, accompanied by a great increase of IL-6 in serum, were observed. Role of polymorphonuclear leukocytes and IL-6 overproduction as responsible for immune dysregulation and paraneoplastic syndromes are discussed.
Adenocarcinoma↗
[The problem of acalculia: a study of a case].
1)The Authors describe a case of acalculia and emphasize some peculiar aspects, the study of which was facilitated by being the patient a mathematics teacher. 2) The patient was unable to perform arithmetic operations (addition and subtraction) but was able to carry our more complex and algebric operations. The acalculia was associated with constructional apraxia. 3) These findings are discussed and the hypothesis is suggested that simple mental arithmetic calculations need spatial operations which are not required for more complex mathematical reasoning and that the ability for calculation may decline by the very same progression, one level after the other, as the language.
Brain Diseases↗
[Diagnostic problems posed by hypotrophic facio-scapulo-humeral syndromes (author's transl)].
The Authors, on the ground of the literature and of their own observations, stress the diagnostic non specificity of hypotrophic facio-scapulo-humeral syndromes: these sindromes, contrary to the current opinion, aren't always of primitive myodistrophic nature but may also be "neurogenic", inflammatory, collagenopathis, etc. In this connection they present an illustrative case of facio-scapulo-humeral syndrome which had clinical features typically "myogenic" but turned out to be "neurogenic" after electromyographic and histochemical investigation.
Electromyography↗
[The problem of spinal myoclonus (author's transl)].
A case of the so called "spinal myoclonus" in a 71 year-old-man affected by lung carcinoma is reported. Clinical manifestations and comparison with similar previously described in literature induce to believe in the existence of a myoclonic syndrome, whose pattern seems to give support to the attribute of "spinal", at least as conventional term. An involvement of intercalated neurons is advanced as pathogenic ground. Anyhow, possible suprasegmental implications are also considered.
Aged↗
[Duchenne muscular dystrophy in girls (author's transl)].
The AA., after a review cases of girls suffering from a muscular dystrophy like Duchenne, present two cases that they think to set in the same nosographical context. Even though they admit its extreme rarity and the possiblility that many cases previously published are controversial, they accept that Duchenne myodistrophic syndromes certainly occur in girls, even if their substantial nature remain uncertain.
Adolescent↗
[Erythrocytes' deformations in primitive muscular dystrophies (author's transl)].
On the light of previous reports on a possible correlation between echinocytogenesis and primitive muscular dystrophies, we have investigated the presence and time dependent development of echinocytes in the blood of normal subjects, patients and healthy carriers of D.M.D. A very few echinocytes are present in the fresh blood of all the patients and some carriers, but not in the blood of control normal subjects. With time, more echinocytes develop in all cases but much more markedly for sick people and carriers. These results might explain conflicting data on the echinocyte content in the blood reported in the literatura and provide a guideline for a correct analysis of the phenomenon and its possible relevance in the eugenetic diagnosis of carriers.
Biopsy↗
[Some clinical and paraclinical observations about the syndrome of "acropathie ulcero-mutilante" (author's transl)].
A case of "acropathie ulcero-mutilante" is reported, some features of which contribute to a better knowledge of the following controversial points: a) the occurrence of sporadic non familiar cases; b) the existence of degenerative changes in the motor pathways; c) the hystochemical picture, which has been not previously described. This case confirm sporadicity and degenerative changes in motor pathways. The histochemical picture show typical signs of denervation.
Arthritis↗
[Further remarks on histochemistry applied to myodiagnosis: findings of "type predominance" (author's transl)].
Data concerning muscular biopsies (histochemically examined) of three patients affected by Charcot-Marie-Tooth disease, neurogenic atrophy of spondilosic origin and benign congenital hypotonia, are described. The common finding was a histochemical appearence of "type predominance". This point and the possible "neurogenic" origin of benign congenital hypotonia, are discussed.
Adult↗