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Biomedical subjects

M Prosiegel

Publications and source records attributed to M Prosiegel.

26 records · Page 2Linked to original sources
PubMed1983

Multivariate analysis of the serum-cerebrospinal fluid-protein-relation for the diagnosis of neurological diseases of the central nervous systems.

In a population comprising 197 patients, serum and CSF proteins were assayed using the radial immunodiffusion technique devised by Mancini. Multiple discriminants analysis was applied to investigate whether the measured CSF/serum protein relations and their ratios could be regarded as an indicator of specific neurological diseases. One significant finding was that the slope angle alpha of the regression line between the serum/CSF relation and molecular weight may represent an important indicative parameter. A small angle is suggestive of enhanced permeability of the BBB, a large angle of a correspondingly lowered permeability. Further, the analyses demonstrated that the combined use of several predictors can markedly improve differential diagnosis. The study also demonstrates the potential of a statistical analytic technique that is still rarely applied in medicine.

Blood Proteins↗
PubMed1983

Influence of human allergic encephalitogenic peptide on platelet aggregation in multiple sclerosis.

After addition of encephalitogenic peptide to the blood of multiple sclerosis patients a factor X with platelet aggregation activating property could be demonstrated in the supernatant serum. Factor X was able to induce a platelet aggregation or to enhance an ADP-induced platelet aggregation. These findings suggest an explanation for the well-known platelet alterations found in multiple sclerosis.

Acute Disease↗
PubMed1982

[Cluster headache].

Cluster headache is a defined disorder which is often mistaken in spite of its characteristic picture. The different types of cluster headache and their clinical symptoms are reviewed in detail. Predisposing factors, frequency of other medical disorders as well as personal and psychological characteristics are described. The treatment of the attack and the prophylaxis includes ergot alkaloids, methysergide, cortisone, lithium and oxygen. Some aspects of etiology and pathogenesis are discussed.

Adult↗
PubMed1982

Platelet aggregation and multiple sclerosis.

Measurements of blood platelet aggregation were carried out in 30 patients suffering from multiple sclerosis (MS) and in 15 healthy individuals. Compared with the control group, the MS patients showed an increase in both spontaneous and induced (ADP and serotonin) platelet aggregation. The possible pathogenetic significance of these results is discussed.

Adenosine Diphosphate↗
PubMed1981

[Cerebrospinal fluid passage of therapeutic immunoglobulins of the IgG class in infectious inflammatory disease of the CNS].

Immunoglobulins are often used as an optimizing therapy in cases of infectious diseases of the central nervous system. To clarify the question of whether or not an intravenously administered compound of the IgG class is able to penetrate the cerebrospinal fluid barrier despite its high molecular weight, 12 anti-HBs negative patients received 20 ml each of a beta-Propiolacton treated IgG compound with a high anti-HBs titre (1 : 115 000) used as a marker. Four patients having an inconspicuous fluid condition were consulted for control. Five patients were suffering from slight disturbances and three other patients had severe disorders of the blood-cerebrospinal fluid barrier function resulting from inflammatory diseases of the central nervous systems. Cerebrospinal fluid was produced by way of lumbar puncture resp. drainage for the determination of anti-HBs. Simultaneously, the concentration of antibodies in serum was determined. In all patients having barrier disturbances, anti-HBs was evident in the cerebrospinal fluid, the transfer of intravenously administered immunoglobulins to cerebrospinal fluid increasing in correlation with the degree of the barrier disorder. The therapeutical importance of immunoglobulin therapy in treating infections of the central nervous system is pointed out.

Adult↗
PubMed1980

[The locked-in syndrome. A case report].

Based on five of our own cases and the literature on hand the etiological, clinical, diagnostic and intensive therapeutic aspects of the syndrome are represented. Special emphasis is placed on the possible role of the oral contraceptives in triggering this syndrome.

Adult↗