[Reappearance of malaria in Corsica. Value of a seroepidemiologic studies].
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Biomedical subjects
Publications and source records attributed to M Quilici.
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We have carried out a retrospective study on 100 children in hospital in Marseilles, France with a diagnosis of Plasmodium falciparum malaria. On admission, the main clinical features were anaemia (90 cases), fever (83 cases, > 40 degrees C in 22 cases), hepatomegaly (44 cases), vomiting (29 cases), neurological signs (22 cases), thrombocytopenia (13 cases), hyperparasitaemia (6 cases), jaundice (4 cases), shock (1 case) and hypoglycaemia (1 case). Severe malaria, as defined by the World Health Organization Malaria Action Programme, was rare in our study (only 2 cases) and the prognosis was good (no death, no sequela). The search for neurological signs such as impaired consciousness, prostration or convulsions is an effective and simple way to diagnose potentially severe cases. In the presence of these signs, intravenous quinine treatment resulted in a shortened duration of fever (30 h instead of 63 h) and thereby avoided patients becoming worse. In children without neurological signs or persistent vomiting, oral therapy may be used even if there is high fever or hyperparasitaemia, but close surveillance is required. Patients treated with halofantrine or mefloquine had a shorter stay in hospital than those treated with chloroquine (mean = 4 d instead of 5.7 d). The resistance of some strains to chloroquine may explain this difference.
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A coprological examination was performed among 410 adults living in two rural traditional villages of the Bamako region (Mali Republic). The results are compatible with those of several reports coming from other areas. A remark is done about Ascaridiasis which seems to be rare in rural communities of tropical Africa.
A study on the incidence and gravity of malaria among children suffering of sickle cell anemia was carried out in the pediatric hospital of Bamako-Mali. On the 236 cases of fever studied, 54.2% were malaria infected and 21.2% were carriers of the sicklemic trait. There was a significant difference between malaria affecting AA children and HbS children, specially concerning parasites load.
From may 1989 to january 1990, we have studied parasitologic index in snails population, stools and urines examination in children (1-15 years) in one of the greatest "spontaneous" quarter of Bamako. 584 stools samples and 563 urines were tested. 4.717 snails were captured during six months. From all these data, we conclude that in Bankoni S. haematobium is mesoendemic (36.6%) and S. mansoni hypoendemic (3.4%). B. truncatus is the most important host for urogenital schistosomiasis. The two seasonal revers (Tienkole and Bankoni) are unfavourable to B. pfeifferi's production. B. globosus and B. forskalii are not frequent in this suburban area. This investigation, shows that a selective mass treatment with praziquantel is the better public health care strategy in Bankoni quarter.
The authors report the distribution and the incidence of dracunculiasis in the seven administrative regions of Mali. They describe the various types of Cyclops habitat and the seasonal variations in transmission. They discuss the resulting effects of dryness and rural water development on this endemic parasitic disease.
Analysis of larval antigens from Armillifer armillatus by PAGE-SDS and immunoblotting techniques allows us to identify the most specific proteins usable for immuno diagnostic and sero-epidemiological surveys.
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