Biomedical subjects
Publications and source records attributed to M Radke.
Within the last ten years an increasing number of Helicobacter pylori-related inflammatory gastroduodenal diseases in children has been reported. The aim of this paper is to describe the range of Helicobacter pylori infections in children including diagnosis and treatment by application of colloidal bismuth salts.
The potential influence of phosphates in formulas on intestinal microflora was studied in 25 infants, aged 8 days to 12 weeks. The babies were either fed an infant formula with the usual phosphate concentration (n = 10) or an infant formula with reduced phosphate and protein concentrations (n = 7). The microbiological findings were compared with those obtained from breastfed infants (n = 8). Low-phosphate concentrations did not correlate with a predominance of bifidobacteria or suppression of putrefactive bacteria in the feces. The fecal excretion of phosphates and fat was found to be significantly lower with mother's milk compared to formulas both rich and poor in phosphate. Protein synthesis and breakdown rates, as well as the net protein gain, did not have a significant correlation with protein intake.
The utilization of 15N nitrogen from 15N-labelled bifidobacteria for whole body protein synthesis was studied in 4 infants by oral single-pulse labellings and in 3 other infants, who had colostomies, by colonic pulse labellings. The bifidobacteria were harvested from a modified Petuely culture medium containing 15N ammonium chloride and 15N cystine as the only sources of nitrogen. The tracer dose chosen for the balance studies was 3 mg 15N/kg. 15N concentrations in urine and feces collected over 48 hours after the pulse labellings were determined by emission spectrometry. Oral administration of 15N-labelled bifidobacteria resulted in absorption of approximately 90% renal excretion of 15%, and fecal excretion of 12% of the tracer dose, respectively. Retention in the protein pool averaged 73%. After colonic single pulse labelling with 15N-labelled bifidobacteria, the corresponding values were 85.5%, 2.2%, 14.5% and 83.0%, respectively. Absorption and incorporation of the heavy nitrogen into body proteins were directly demonstrated by increased 15N atom percent excess values within the trichloroacetic acid (TCA) supernatants and the proteins of the plasma, 0.25 and 0.04 atom%, respectively, at 24 hours after oral pulse labellings. One half of the total 15N excreted in urine consisted of urea and approximately 8% was eliminated as ammonia.
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Most neonatal Herpes-simplex-virus infections are the result of virus acquisition during passage through the birth canal. Transplacental transmission of HSV is seldom. The infection is mostly localized at the skin, eyes and central nervous system. The disseminated HSV-infection represents as the most severe clinical picture. It is reported about meningoencephalitis caused by HSV in 3 infants in the first weeks of life. The therapeutic success of antiviral chemotherapeutics depends very much on their application at an early stage of the disease, which can be recognized by cerebral sonography and detection of IgM-antibodies against HSV.
The immunogenicity of a native whey protein-casein mixture (relation 60:40) was compared with an analogous mixture which had been subjected to Warren's hydrolysis procedure for splitting off sialic acid. The immunization was performed in 3 rabbits each, with a mean body weight of 4,200 g. After parenteral administration of an antigen dose corresponding to 2 mg protein for 6 times, 10 ml blood were withdrawn from each of the animals on day 80 of the immunization procedure. The serum of those rabbits which had been injected the native whey protein-casein mixture was shown to precipitate this antigen intensively as could be demonstrated by Mancini's test. The cross reaction with the sialic acid-free protein mixture was strongly diminished. Immunization with sialic acid-free whey protein-casein failed to produce worth-while antibody formation against this antigen. Only a moderate cross reaction with native whey protein-casein was detectable. These results may have potential consequences for the production of infant formulas and dietaries.
Peiper's scientifical biography and his contribution for development of GDR-pediatrics in the 50th are described. His manyfold activities as physician and scientist during his directorship in the department of pediatrics of Leipzig university (1948-1958) are appreciated.
In 3 infants with meningoencephalitis caused by Herpes simplex viruses the findings of cerebral sonography corresponded with those of computerized tomography and electroencephalography. The therapeutic success of antiviral chemotherapeutics depends very much on their application at an early stage of the disease, which can be recognized by cerebral sonography.
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