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Biomedical subjects

M Radkowski

Publications and source records attributed to M Radkowski.

96 records · Page 6Linked to original sources
PubMedDate not supplied

[Markers of hepatitis A infection in drug addicts].

Prevalence of HAV infection markers was studied in 100 drug addicts whose sera were collected between 1988 and 1989. Anti-HAV antibodies were found in 65 (65%) of the tested drug addicts and in 55% of the individuals serving as the control group. No correlation between the presence of HAV infection markers, and sex, duration of drug abuse or HIV status was seen. However, drug addicts with anti-HAV antibodies were older than those without these antibodies. There was no difference in a mean titre of anti-CMV and anti-HSV type 1 antibodies between the individuals with and without HAV infection markers. It suggests that the tested markers are specific for HAV infection.

Adult↗
PubMedDate not supplied

[Mechanism of cell infection with HIV].

The mechanisms of HIV infection of target cells are described. Particularly the role of three types of cell receptors, which participate in the process of virus-cell interactions: CD4 protein, receptor for Fc fragment of antibodies and complement receptors are discussed. The variability of the virus variants, which determines the virus tropism and cytotoxic properties towards specific cell types is stressed.

CD4 Antigens↗
PubMedDate not supplied

[Appearance of thrombocytopenia in patients infected with HIV].

Results of quantitative determinations of thrombocytes and selected, basal immune parameters in 263 HIV infected subjects are presented. A decrease in the platelet count was observed more frequently in symptomatic subjects, including AIDS patients, than in asymptomatic HIV carriers or patients with generalized lymphadenopathy only. A significant correlation between thrombocyte number and percentage and number of CD4+ lymphocyte and CD4+/CD8+ lymphocyte ratio was found only in the group of symptomatic subjects. The mechanisms responsible for thrombocytopenia in HIV infected patients ore discussed in details.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

The occurrence of infectious and parasitic diseases in poultry slaughtered in the district of Olsztyn, Poland, 1986-91.

During 6 years, 1986-91, in poultry processing plants in the district of Olsztyn, Poland, 37,779,959 carcasses and internal organs of slaughtered fattened poultry were (1,691,188 hens, 23,681,855 chickens, and 12,226,016 turkeys) were examined. As a result of the antemortem and postmortem inspections, 744,499 birds were condemned for human consumption, which was 1.66% of the total number of birds examined. The highest percentage of condemned birds was registered in hens (2.4%) and the lowest in chickens (1.27%). By means of a medical examination, the following diseases were diagnosed most frequently in chickens: Marek's disease in 2,265 birds (0.095%), salmonellosis in 13,463 birds (0.056%), coccidiosis in 9,548 birds (0.04%), and chronic illness of the respiratory system in 377 birds (0.0016%). In hens, salmonellosis was found in 15,951 birds (0.94%), tuberculosis in 301 birds (0.018%), leukemia in 122 birds (0.007%), and aspergillosis in 71 birds (0.0042%). In turkeys, chronic illness of the respiratory system was found in 23,938 birds (0.196%), aspergillosis in 13,243 birds (0.11%), salmonellosis in 3,918 birds (0.032%), and leukemia in 29 birds (0.00024%).

Abattoirs↗
PubMedDate not supplied

The effect of a nitric oxide inhibitor (L-NAME) on peritoneal transport during dialysis in rats.

OBJECTIVE: To assess the effect of an inhibitor of nitric oxide synthesis [N(G)-nitro-L-arginine methyl ester (L-NAME)] on peritoneal transport during peritoneal dialysis (PD) and peritonitis in rats. METHODS: The authors studied peritoneal transport of small and large solutes, and net ultrafiltration (UF) in rats during PD with Dianeal 3.86 (Baxter, McGaw Park, IL, U.S.A.). They evaluated the effect of L-NAME used as an additive to dialysis fluid in concentrations 0.5-5 mg/mL on peritoneal transport of small and large molecules and on transperitoneal UF. In addition, they studied the effect of L-NAME (5 mg/mL) during acute peritonitis induced by lipopolysaccharides (5 microg/mL) given intraperitoneally. RESULTS: The addition of L-NAME to dialysis fluid increased the selectivity of the peritoneum and net UF during dialysis. Lipopolysaccharides used as an additive to the dialysis fluid, together with L-NAME, did not induce changes in transperitoneal transport of small and large solutes and did not cause a significant decline in net UF. L-NAME given intraperitoneally reduced both local and systemic production of nitric oxide, which might explain its effects on peritoneal transport. CONCLUSIONS: Nitric oxide is an important mediator of changes in peritoneal transport and its effect is especially significant during peritonitis.

Animals↗