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Biomedical subjects

M Radu-Toader

Publications and source records attributed to M Radu-Toader.

7 recordsLinked to original sources
PubMedDate not supplied

Dynamics of protein modifications in the skeletal muscle following formol injection.

The concentrated formol injections in the skeletal muscle of rat induce the appearance of histological modifications of the destructive type, followed after a period of time by modifications of the restoring-regenerative type. The histochemical reactions for the demonstration of proteins undergo significant alterations during these processes. In a first stage the reactions are negative while during the restoration stage -- together with the appearance of myoblasts sarcoblasts and muscular buds -- they become intensely positive, as an expression of protein synthesis intensification.

Animals↗
PubMedDate not supplied

Spleen and lymph node reticulofibrosis in "chemically thyroidectomized" rats.

The effects of the X-rays on the peripherial lymphoid organs (lymph nodes and spleen) in male adult wistar rats "chemically thyroidectomized" (methylthiouracil) have been studied. Spontaneous death of these animals 9 days after the irradiation was determined by the hypoplasia (aplasia) of the hematogenous bone marrow. The spleen and lymph node changes -- represented by the lymphoid tissue depletion and reticulofibrosis -- in the experimental animals were similar to those observed in animals sacrificed 6-8 months after irradiation. They differed from the latter by the absence of the macromolecular hyperstability of the reticular and collagenous fibers, which is proper to early ageing by X-rays.

Aging↗
PubMedDate not supplied

Spleen and lymph node changes in rats irradiated with X-rays and treated with testosterone.

The authors have studied the effect of testosterone administration in male adult Wistar rats irradiated with a single total dose of 800 r X-rays. The results obtained show that testosterone exerts a double radioprotective action. This hormone prevents both the occurrence of the senile type spleen and lymph node changes and the depression of the colloidopexic capacity of the hepatosplenic macrophages. At the same time, these results suggest that testosterone induces hyperplasia of the lymphocytic elements, particularly of T lymphocytes.

Aging↗
PubMedDate not supplied

Effects of the "reverse" administration of sexual hormones on the lymph node structure in irradiated Wistar rats.

The whole-body irradiation of adult Wistar rats with a single dose of 800 r X-rays intensifies the lymph node changes and the decrease of the colloidopexic capacity of hepatosplenic macrophages established by the "reverse" administration of sexual hormones. The modifications observed after estradiol administration to the male rat are more marked after a 6 months' interval than those caused in the same interval by testosterone in the female rat lymph nodes.

Animals↗
PubMedDate not supplied

Postcortisone medullary changes in the irradiated and unirradiated male Wistar rat.

Cortisone administration in male Wistar rat induces a depletion of the granulocytic-normoblastic cell population in the bone marrow in parallel with a numerical increase by accumulation of lymphoid and undifferentiated cells. These changes are more intense under irradiation conditions. The reversibility of medullary modifications is shown by the integrity of the reticulinic skeleton of the bone marrow.

Animals↗
PubMedDate not supplied

Postovariectomy bone marrow changes in irradiated and unirradiated wistar rats.

Bilateral ovariectomy of Wistar rats has per se a stimulative effect on the myeloid tissue, determining a hypercellularity of this organ-tissue. On the other hand, under the conditions of a whole-body irradiation with a single dose of 800 r X-rays, bilateral ovariectomy manifests a protective effect on the myeloid tissue preventing the development of hypoplastic, respectively aplastic modifications.

Adipose Tissue↗